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>>INCLUSION CRITERIA<< DISEASE CHARACTERISTICS:

• - Clinical diagnosis of bilateral intraocular retinoblastoma (RB) - International Intraocular Retinoblastoma Classification (IIRC) Group B, C, or D disease in 1 or both eyes.

• - IIRC Group E disease in 1 eye allowed provided the eye was enucleated at diagnosis AND there is no extraocular RB in the enucleated eye by histologic confirmation AND there is IIRC Group B, C, or D disease in the remaining eye.

PATIENT CHARACTERISTICS: Age.

• - Over 30 days.

Performance status.

• - Not specified.

Life expectancy.

• - Not specified.

Hematopoietic.

• - Not specified.

Hepatic.

• - AST and ALT < 2 times upper limit of normal (ULN) - Conjugated and unconjugated bilirubin < 2 times ULN.

Renal.

• - Creatinine < 1.5 times ULN.

• - Glomerular filtration rate (GFR) ≥ 100 mL/min* NOTE: *A 4-hour IV hydration is allowed if GFR is low due to poor hydration or transient dehydration.

Other.

• - Meets 1 of the following auditory criteria: - Normal audiogram.

• - At least normal responses to speech by audiogram.

• - Documentation of hearing by acoustic emission test.

• - Recording of evoked potentials by auditory brain stem response.

PRIOR CONCURRENT THERAPY: Biologic therapy.

• - Not specified.

Chemotherapy.

• - Not specified.

Endocrine therapy.

• - Not specified.

Radiotherapy.

• - Not specified.

Surgery.

• - See Disease Characteristics.

>>EXCLUSION CRITERIA<<

• - IIRC Group A disease in 1 or both eyes.

• - unilateral RB.

• - extraocular or metastatic RB.

• - younger than 30 days.

- Glomerular filtration rate (GFR) < 100 mL/min

OBJECTIVES: Primary.

• - Compare the efficacy of neoadjuvant high-dose carboplatin and etoposide, vincristine, and cyclosporine (CSA) followed by ophthalmic focal therapy comprising cryotherapy and/or laser therapy to historical world data of chemotherapy treatment without CSA, in terms of increasing the proportion of eyes that remain relapse free and do not require external beam radiotherapy and/or enucleation, in patients with newly diagnosed Group B, C, or D bilateral intraocular retinoblastoma.

Secondary.

• - Determine the toxicity of this regimen in these patients.

OUTLINE: This is a multicenter study. Patients receive high-dose carboplatin IV over 30 minutes on day 1; vincristine IV over 5 minutes and high-dose etoposide IV over 25 minutes on day 2; cyclosporine IV over 1 hour before chemotherapy and then over 2 hours after chemotherapy on days 1 and 2, and filgrastim (G-CSF) subcutaneously once daily beginning on day 3 and continuing until day 16 or until blood counts recover. Treatment repeats every 21 days for a total of 3 courses for patients with Group B disease and a total of 6 courses for patients with Group C or D disease. Patients undergo eye examination under anesthesia (EUA) at initial staging and then before each course of chemotherapy. Patients with small peripheral tumors in eyes without retinal detachment undergo minimal focal therapy (mainly cryotherapy) during EUA at initial staging and then after chemotherapy courses 1 and 2. At EUA after the third and subsequent courses of chemotherapy, patients with tumors that have sufficiently reduced in size undergo additional cryotherapy or laser therapy. After completion of chemotherapy, patients with any suspicious, active, or reactivated tumor undergo additional cryotherapy and/or laser therapy during EUA approximately every 4-8 weeks (or at longer intervals) for up to 5 years (as needed). After completion of study chemotherapy, patients are followed every 3 months for 2 years, every 6 months for 2 years, and then annually for 1 year. PROJECTED ACCRUAL: A total of 71 patients will be accrued for this study within 2.4 years.

Arms

Experimental: CEV Chemo + Cyclosporine & Focal Therapy

Systemic carboplatin (28 mg/kg/dose), etoposide (12 mg/kg/dose) and vincristine sulfate (0.025 mg/kg/dose for the first cycle and 0.05 mg/kg/dose for subsequent cycles if first cycle well-tolerated) chemotherapy given with cyclosporin A (33 mg/kg/dose). Following 4-6 cycles CEV chemotherapy (depending on tumor stage) given every 3 weeks, focal laser therapy and/or cryosurgery are applied for tumor consolidation. Filgrastim is given after each chemotherapy cycle to prevent severe neutropenia.

Interventions

Biological: - filgrastim

Given after chemo cycle for 7 days or until neutrophil counts return to normal.

Drug: - Carboplatin

Given at 28 mg/kg/dose.

Drug: - Cyclosporine

Given at 33 mg/kg/dose

Drug: - Etoposide

Given at 12 mg/kg/dose

Drug: - vincristine sulfate

Given at 0.025 mg/kg/dose for the first cycle and 0.05 mg/kg/dose for subsequent cycles if first cycle well-tolerated

Procedure: - cryosurgery

Local application of extreme cold to destroy residual tumor.

Procedure: - laser therapy

Local and precise application of laser beams to destroy residual tumor.