Get Involved
Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET
Study Purpose
This phase III trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma. Chemotherapy drugs, such as vincristine sulfate, cisplatin, cyclophosphamide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 3 Years - 22 Years |
| Gender | All |
Inclusion Criteria:
- - Age greater than or equal to 3 and less than 22 years at the time of diagnosis.
- - Newly diagnosed, previously untreated: (1) M0 medulloblastoma with > 1.5 cm^2 residual; (2) M+ medulloblastoma; patients with diffusely anaplastic medulloblastoma are eligible regardless of M-stage or residual tumor.
- - As of amendment # 2, enrollment of patients with supratentorial PNET has been discontinued.
- - All patients with M4 disease are not eligible.
- - A pre-operative magnetic resonance imaging (MRI) scan of the brain with and without contrast is required; NOTE: computed tomography (CT) scans are NOT sufficient for study eligibility since radiation therapy planning and response will be based on MRI scans only.
- - Post-operative head MRI scan with and without contrast (preferably within 72 hours post-surgery); for patients who undergo stereotactic biopsy only, either a pre or post-operative MRI is sufficient; for patients with M2 and M3 disease, a post-op MRI is strongly encouraged, but not mandatory.
- - Spinal MRI imaging with and without gadolinium is required within 10 days of surgery if done pre-operatively or within 28 days of surgery if done post-operatively; for posterior fossa tumors, pre-operative MRI scans are preferred because surgically-induced inflammation/blood can be difficult to distinguish from tumor.
- - Lumbar cerebrospinal fluid (CSF) cytology examination must be obtained pre-operatively or within 31 days following surgery; the optimal time for obtaining CSF is prior to surgery or 1-3 weeks following surgery; ventricular CSF (either pre- or post-op) may be used only if a post-operative spinal tap is contraindicated; if a spinal tap is contraindicated and there is no ventricular CSF available, then CSF cytology can be waived for patients with supratentorial tumors or if there is documentation of spinal subarachnoid metastases (M3); patients who are categorized as M1 must have either an intra-operative positive CSF (via lumbar puncture at the end of the procedure) or a positive lumbar CSF obtained > 7 days post-operatively (to rule out surgically induced false positives) - Patients must have a Karnofsky performance level of >= 30 for patients > 16 years of age or a Lansky performance scale of >= 30 for patients =< 16 years of age and life expectancy > 8 weeks.
- - No previous chemotherapy or radiation therapy.
- - Corticosteroids should not be used during chemotherapy administration as an antiemetic because of their effect on the blood-brain barrier.
- - Clinically significant drug interactions have been reported when using vincristine with strong CYP450 3A4 inhibitors and inducers.
- - The clinical outcome and significance of CYP450 interactions with cyclophosphamide are less clear.
- - Cisplatin should be used with caution with nephrotoxic drug; aminoglycoside should be avoided or used with caution during or shortly after cisplatin administration and concomitant use with amphotericin B should probably also be avoided; patients receiving cisplatin and other potentially ototoxic drugs such as aminoglycoside or loop diuretics concomitantly should be closely monitored for signs of ototoxicity.
- - In patients receiving cisplatin and phenytoin or fosphenytoin, serum concentrations of phenytoin may decrease.
- - No other experimental therapy is permitted while on study.
- - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows: - 0.8 mg/dL (2 to < 6 years of age) - 1.0 mg/dL (6 to < 10 years of age) - 1.2 mg/dL (10 to < 13 years of age) - 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age) - 1.7 mg/dL (male) or 1.4 mg/dL (female) (>= 16 years of age) - Total bilirubin < 1.5 x upper limit of normal (ULN) for age.
- - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x upper limit of normal (ULN) for age; for patients on anti-seizure medications, SGOT (AST) or SGPT (ALT) must be < 5 x ULN.
- - Absolute neutrophil count (ANC) >= 1,000/uL.
- - Platelets >= 100,000/uL (untransfused) - Hemoglobin >= 8 g/dl (may be transfused) - There is information indicating a risk of fetal or teratogenic toxicity with this treatment.
- - All patients and/or their parents or legal guardians must sign a written informed consent.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00392327 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Sarah E Leary |
| Principal Investigator Affiliation | Children's Oncology Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | Australia, Canada, Netherlands, Puerto Rico, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Anaplastic Medulloblastoma, Medulloblastoma |
PRIMARY OBJECTIVES:
- I. To determine whether carboplatin radiosensitization increases long term event-free survival for high risk medulloblastoma/primitive neuroectodermal tumor (PNET) patients.
- II. To determine whether isotretinoin increases long term event-free survival for high risk medulloblastoma/PNET patients.
- I. To compare residual disease response to radiation alone versus radiation plus carboplatin.
- II. To identify molecular prognostic indicators suitable for patient stratification in future trials.
- III. To evaluate the health-related quality of life (HRQOL) during phases of active treatment specific to treatment modalities.
- IV. To describe the neuropsychological functioning of the study population and to evaluate the relationship between neuropsychological status and health related quality of life.
- I. Patients also receive carboplatin IV over 15 minutes on each day of radiation therapy.
- I. Patients also undergo blood sample collection, lumbar puncture and MRI throughout the study.
- - CLOSED TO ACCRUAL 1/27/15): CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in Arm I.
- - CLOSED TO ACCRUAL 1/27/15): CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in Arm II.
- III. Patients then proceed to continuation therapy.
- III. After completion of study treatment, patients are followed up periodically for 1 year.
Arms
Active Comparator: Arm A (chemoradiotherapy)
CHEMORADIOTHERAPY: Patients undergo radiation therapy QD five days a week for 6 weeks. Patients also receive vincristine sulfate IV over 1 minute once weekly for 6 weeks. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy. MAINTENANCE THERAPY: Patients receive cisplatin IV over 6 hours on day 1, vincristine sulfate IV over 1 minute on days 1 and 8, and cyclophosphamide IV over 1 hour on days 2 and 3. Patients also receive filgrastim SC or IV beginning on day 4 and continuing until blood counts recover (at least 10 days). Treatment repeats every 28 days for a total of 6 courses in the absence of disease progression or unacceptable toxicity. Patients also undergo blood sample collection, lumbar puncture and MRI throughout the study.
Experimental: Arm B (chemoradiotherapy)
CHEMORADIOTHERAPY: Patients receive vincristine sulfate and undergo radiation therapy as in Arm A. Patients also receive carboplatin IV over 15 minutes on each day of radiation therapy. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy. MAINTENANCE THERAPY: Patients receive maintenance therapy as in Arm A. Patients also undergo blood sample collection, lumbar puncture and MRI throughout the study.
Experimental: Arm C (chemoradiotherapy, isotretinoin-CLOSED TO ACCRUAL)
CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in Arm A. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy. MAINTENANCE THERAPY: Patients receive isotretinoin PO BID on day 1 and days 16-28 and cisplatin, vincristine sulfate, cyclophosphamide, and filgrastim as in Arm A maintenance therapy. Treatment repeats every 28 days for a total of 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to continuation therapy. CONTINUATION THERAPY: Patients receive isotretinoin PO BID on days 15-28 every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity.
Experimental: Arm D (chemoradiotherapy, isotretinoin-CLOSED TO ACCRUAL)
CHEMORADIOTHERAPY: Patients undergo chemoradiotherapy as in Arm B. Six weeks after completion of chemoradiotherapy, patients proceed to maintenance therapy. MAINTENANCE THERAPY: Patients receive maintenance therapy as in Arm C. Patients then proceed to continuation therapy. CONTINUATION THERAPY: Patients receive continuation therapy as in Arm C.
Interventions
Procedure: - Biospecimen Collection
Undergo blood sample collection
Drug: - Carboplatin
Given IV
Drug: - Cisplatin
Given IV
Drug: - Cyclophosphamide
Given IV
Biological: - Filgrastim
Given IV or SC
Drug: - Isotretinoin
Given PO
Procedure: - Lumbar Puncture
Undergo lumbar puncture
Procedure: - Magnetic Resonance Imaging
Undergo MRI
Other: - Quality-of-Life Assessment
Ancillary studies
Radiation: - Radiation Therapy
Undergo radiation therapy
Drug: - Vincristine Sulfate
Given IV
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Children's Hospital of Alabama
Birmingham 4049979, Alabama 4829764, 35233
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764, 35233
Status
Address
Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092, 99508
Status
Address
Banner Children's at Desert
Mesa 5304391, Arizona 5551752, 85202
Status
Address
Arkansas Children's Hospital
Little Rock 4119403, Arkansas 4099753, 72202-3591
Status
Address
Loma Linda University Medical Center
Loma Linda 5367696, California 5332921, 92354
Status
Address
Miller Children's and Women's Hospital Long Beach
Long Beach 5367929, California 5332921, 90806
Status
Address
Children's Hospital Los Angeles
Los Angeles 5368361, California 5332921, 90027
Status
Address
Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921, 90048
Status
Address
Valley Children's Hospital
Madera 5369568, California 5332921, 93636
Status
Address
UCSF Benioff Children's Hospital Oakland
Oakland 5378538, California 5332921, 94609
Status
Address
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921, 94611
Status
Address
Children's Hospital of Orange County
Orange 5379513, California 5332921, 92868
Status
Address
Lucile Packard Children's Hospital Stanford University
Palo Alto 5380748, California 5332921, 94304
Status
Address
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921, 95816
Status
Address
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921, 95817
Status
Address
Rady Children's Hospital - San Diego
San Diego 5391811, California 5332921, 92123
Status
Address
UCSF Medical Center-Parnassus
San Francisco 5391959, California 5332921, 94143
Status
Address
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921, 94158
Status
Address
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance 5403022, California 5332921, 90502
Status
Address
Children's Hospital Colorado
Aurora 5412347, Colorado 5417618, 80045
Status
Address
Connecticut Children's Medical Center
Hartford 4835797, Connecticut 4831725, 06106
Status
Address
Yale University
New Haven 4839366, Connecticut 4831725, 06520
Status
Address
Alfred I duPont Hospital for Children
Wilmington 4145381, Delaware 4142224, 19803
Status
Address
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106, 20007
Status
Address
Children's National Medical Center
Washington D.C. 4140963, District of Columbia 4138106, 20010
Status
Address
Golisano Children's Hospital of Southwest Florida
Fort Myers 4155995, Florida 4155751, 33908
Status
Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751, 33021
Status
Address
Nemours Children's Clinic-Jacksonville
Jacksonville 4160021, Florida 4155751, 32207
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Address
Nicklaus Children's Hospital
Miami 4164138, Florida 4155751, 33155
Status
Address
AdventHealth Orlando
Orlando 4167147, Florida 4155751, 32803
Status
Address
Arnold Palmer Hospital for Children
Orlando 4167147, Florida 4155751, 32806
Status
Address
Nemours Children's Hospital
Orlando 4167147, Florida 4155751, 32827
Status
Address
Nemours Children's Clinic - Pensacola
Pensacola 4168228, Florida 4155751, 32504
Status
Address
Johns Hopkins All Children's Hospital
St. Petersburg 4171563, Florida 4155751, 33701
Status
Address
Tampa General Hospital
Tampa 4174757, Florida 4155751, 33606
Status
Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751, 33607
Status
Address
Saint Mary's Medical Center
West Palm Beach 4177887, Florida 4155751, 33407
Status
Address
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta 4180439, Georgia 4197000, 30329
Status
Address
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000, 31404
Status
Address
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797, 96826
Status
Address
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512, 83712
Status
Address
Lurie Children's Hospital-Chicago
Chicago 4887398, Illinois 4896861, 60611
Status
Address
University of Illinois
Chicago 4887398, Illinois 4896861, 60612
Status
Address
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861, 60637
Status
Address
Loyola University Medical Center
Maywood 4901514, Illinois 4896861, 60153
Status
Address
Advocate Children's Hospital-Oak Lawn
Oak Lawn 4904365, Illinois 4896861, 60453
Status
Address
Advocate Children's Hospital-Park Ridge
Park Ridge 4905367, Illinois 4896861, 60068
Status
Address
Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861, 60068
Status
Address
Saint Jude Midwest Affiliate
Peoria 4905687, Illinois 4896861, 61637
Status
Address
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861, 62702
Status
Address
Riley Hospital for Children
Indianapolis 4259418, Indiana 4921868, 46202
Status
Address
Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868, 46260
Status
Address
Blank Children's Hospital
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182, 52242
Status
Address
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925, 40536
Status
Address
Norton Children's Hospital
Louisville 4299276, Kentucky 6254925, 40202
Status
Address
Children's Hospital New Orleans
New Orleans 4335045, Louisiana 4331987, 70118
Status
Address
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068, 04401
Status
Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885, 21287
Status
Address
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885, 20889-5600
Status
Address
Massachusetts General Hospital Cancer Center
Boston 4930956, Massachusetts 6254926, 02114
Status
Address
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926, 02215
Status
Address
Baystate Medical Center
Springfield 4951788, Massachusetts 6254926, 01199
Status
Address
C S Mott Children's Hospital
Ann Arbor 4984247, Michigan 5001836, 48109
Status
Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
Status
Address
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836, 48236
Status
Address
Michigan State University Clinical Center
East Lansing 4991640, Michigan 5001836, 48824
Status
Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
Status
Address
Kalamazoo Center for Medical Studies
Kalamazoo 4997787, Michigan 5001836, 49008
Status
Address
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis 5037649, Minnesota 5037779, 55404
Status
Address
University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779, 55455
Status
Address
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779, 55905
Status
Address
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296, 39216
Status
Address
University of Missouri Children's Hospital
Columbia 4381982, Missouri 4398678, 65212
Status
Address
Children's Mercy Hospitals and Clinics
Kansas City 4393217, Missouri 4398678, 64108
Status
Address
Cardinal Glennon Children's Medical Center
St Louis 4407066, Missouri 4398678, 63104
Status
Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
Status
Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
Status
Address
Children's Hospital and Medical Center of Omaha
Omaha 5074472, Nebraska 5073708, 68114
Status
Address
University Medical Center of Southern Nevada
Las Vegas 5506956, Nevada 5509151, 89102
Status
Address
Sunrise Hospital and Medical Center
Las Vegas 5506956, Nevada 5509151, 89109
Status
Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151, 89135
Status
Address
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151, 89144
Status
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174, 03756
Status
Address
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760, 07601
Status
Address
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760, 07039
Status
Address
Morristown Medical Center
Morristown 5101427, New Jersey 5101760, 07960
Status
Address
Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760, 08901
Status
Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick 5101717, New Jersey 5101760, 08903
Status
Address
Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760, 07112
Status
Address
Saint Joseph's Regional Medical Center
Paterson 5102466, New Jersey 5101760, 07503
Status
Address
Overlook Hospital
Summit 5105127, New Jersey 5101760, 07902
Status
Address
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136, 87106
Status
Address
Albany Medical Center
Albany 5106834, New York 5128638, 12208
Status
Address
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638, 14263
Status
Address
NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638, 11501
Status
Address
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park 5128514, New York 5128638, 11040
Status
Address
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638, 10016
Status
Address
Mount Sinai Hospital
New York 5128581, New York 5128638, 10029
Status
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638, 10032
Status
Address
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638, 10065
Status
Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
Status
Address
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638, 11794
Status
Address
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638, 13210
Status
Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
Status
Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348, 27599
Status
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348, 28203
Status
Address
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348, 28204
Status
Address
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348, 27157
Status
Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Address
Children's Hospital Medical Center of Akron
Akron 5145476, Ohio 5165418, 44308
Status
Address
Cincinnati Children's Hospital Medical Center
Cincinnati 4508722, Ohio 5165418, 45229
Status
Address
Rainbow Babies and Childrens Hospital
Cleveland 5150529, Ohio 5165418, 44106
Status
Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
Status
Address
Nationwide Children's Hospital
Columbus 4509177, Ohio 5165418, 43205
Status
Address
Dayton Children's Hospital
Dayton 4509884, Ohio 5165418, 45404
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
Status
Address
Mercy Children's Hospital
Toledo 5174035, Ohio 5165418, 43608
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Address
Legacy Emanuel Children's Hospital
Portland 5746545, Oregon 5744337, 97227
Status
Address
Legacy Emanuel Hospital and Health Center
Portland 5746545, Oregon 5744337, 97227
Status
Address
Oregon Health and Science University
Portland 5746545, Oregon 5744337, 97239
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927, 18103
Status
Address
Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927, 18017
Status
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
Status
Address
Penn State Children's Hospital
Hershey 5193342, Pennsylvania 6254927, 17033
Status
Address
Children's Hospital of Philadelphia
Philadelphia 4560349, Pennsylvania 6254927, 19104
Status
Address
Saint Christopher's Hospital for Children
Philadelphia 4560349, Pennsylvania 6254927, 19134
Status
Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh 5206379, Pennsylvania 6254927, 15224
Status
Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Address
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040, 29203
Status
Address
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Greenville Cancer Treatment Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Address
T C Thompson Children's Hospital
Chattanooga 4612862, Tennessee 4662168, 37403
Status
Address
East Tennessee Childrens Hospital
Knoxville 4634946, Tennessee 4662168, 37916
Status
Address
The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168, 37203
Status
Address
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168, 37232
Status
Address
Texas Tech University Health Sciences Center-Amarillo
Amarillo 5516233, Texas 4736286, 79106
Status
Address
Dell Children's Medical Center of Central Texas
Austin 4671654, Texas 4736286, 78723
Status
Address
Driscoll Children's Hospital
Corpus Christi 4683416, Texas 4736286, 78411
Status
Address
Medical City Dallas Hospital
Dallas 4684888, Texas 4736286, 75230
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286, 75390
Status
Address
Cook Children's Medical Center
Fort Worth 4691930, Texas 4736286, 76104
Status
Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286, 77030
Status
Address
M D Anderson Cancer Center
Houston 4699066, Texas 4736286, 77030
Status
Address
Covenant Children's Hospital
Lubbock 5525577, Texas 4736286, 79410
Status
Address
UMC Cancer Center / UMC Health System
Lubbock 5525577, Texas 4736286, 79415
Status
Address
Children's Hospital of San Antonio
San Antonio 4726206, Texas 4736286, 78207
Status
Address
Methodist Children's Hospital of South Texas
San Antonio 4726206, Texas 4736286, 78229
Status
Address
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286, 78229
Status
Address
Scott and White Memorial Hospital
Temple 4735966, Texas 4736286, 76508
Status
Address
Primary Children's Hospital
Salt Lake City 5780993, Utah 5549030, 84113
Status
Address
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283, 05405
Status
Address
Inova Fairfax Hospital
Falls Church 4758390, Virginia 6254928, 22042
Status
Address
Children's Hospital of The King's Daughters
Norfolk 4776222, Virginia 6254928, 23507
Status
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Address
Carilion Children's
Roanoke 4782167, Virginia 6254928, 24014
Status
Address
Seattle Children's Hospital
Seattle 5809844, Washington 5815135, 98105
Status
Address
Providence Sacred Heart Medical Center and Children's Hospital
Spokane 5811696, Washington 5815135, 99204
Status
Address
Mary Bridge Children's Hospital and Health Center
Tacoma 5812944, Washington 5815135, 98405
Status
Address
Madigan Army Medical Center
Tacoma 5812944, Washington 5815135, 98431
Status
Address
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850, 25304
Status
Address
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850, 26506
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468, 54301
Status
Address
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Children's Hospital of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
International Sites
Status
Address
Women's and Children's Hospital-Adelaide
North Adelaide 8469169, South Australia 2061327, 5006
Status
Address
Princess Margaret Hospital for Children
Perth 2063523, Western Australia 2058645, 6008
Status
Address
University of Alberta Hospital
Edmonton 5946768, Alberta 5883102, T6G 2B7
Status
Address
British Columbia Children's Hospital
Vancouver 6173331, British Columbia 5909050, V6H 3V4
Status
Address
CancerCare Manitoba
Winnipeg 6183235, Manitoba 6065171, R3E 0V9
Status
Address
IWK Health Centre
Halifax 6324729, Nova Scotia 6091530, B3K 6R8
Status
Address
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton 5969782, Ontario 6093943, L8N 3Z5
Status
Address
Children's Hospital of Eastern Ontario
Ottawa 6094817, Ontario 6093943, K1H 8L1
Status
Address
Hospital for Sick Children
Toronto 6167865, Ontario 6093943, M5G 1X8
Status
Address
The Montreal Children's Hospital of the MUHC
Montreal 6077243, Quebec 6115047, H3H 1P3
Status
Address
Centre Hospitalier Universitaire Sainte-Justine
Montreal 6077243, Quebec 6115047, H3T 1C5
Status
Address
Saskatoon Cancer Centre
Saskatoon 6141256, Saskatchewan 6141242, S7N 4H4
Status
Address
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec 6325494, , G1V 4G2
Status
Address
Dutch Childhood Oncology Group
Utrecht 2745912, , 3584 CS
Status
Address
University Pediatric Hospital
San Juan 4568127, , 00926
