Get Involved
Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor
Study Purpose
This phase III trial studies how well combination chemotherapy and surgery work in treating young patients with Wilms tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving it after surgery may kill any tumor cells that remain after surgery.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | N/A - 29 Years |
| Gender | All |
Inclusion Criteria:
- - The patient must have one of the following conditions to be eligible: - Synchronous bilateral Wilms tumors**; or.
- - Unilateral Wilms tumor and aniridia, Beckwith-Wiedemann Syndrome, idiopathic hemihypertrophy, Simpson-Golabi-Behmel-Syndrome, Denys-Drash Syndrome or other associated genitourinary anomalies associated with bilateral Wilms tumor, such as hypospadias and undescended testis (to be eligible, these patients must not undergo any nephrectomy at diagnosis; note-horseshoe kidney is not associated with bilateral Wilms tumor and these patients should go on the appropriate unilateral Wilms tumor study); or.
- - Multicentric Wilms tumor (any age) (to be eligible, these patients must not undergo any nephrectomy at diagnosis); or.
- - Unilateral Wilms tumor with contralateral nephrogenic rest(s) (any size) in a child under one year of age (to be eligible, these patients must not undergo any nephrectomy at diagnosis); or.
- - Diffuse hyperplastic perilobar nephroblastomatosis (unilateral or bilateral) defined by central radiological review; or.
- - Wilms tumor arising in a solitary kidney (patients with metachronous Wilms tumor are not eligible) - The AREN0534 study uses the guideline that Wilms tumor with a single lesion 1 cm or greater in the contralateral kidney or multiple lesions (of any size) in the contralateral kidney should be treated on the synchronous bilateral Wilms tumor stratum; patients with an isolated lesion less than 1 cm in the contralateral kidney should be treated on the appropriate study for unilateral Wilms tumor OR on the unilateral Wilms tumor/contralateral nephrogenic rest stratum of this study if they have not undergone nephrectomy and are under one year of age.
- - Loss of heterozygosity (LOH) results-which are used in the unilateral Wilms tumor studies-are not a requirement for enrollment on AREN0534; blood samples can be submitted but will not be used to direct AREN0534 therapy.
- - Specimens/materials must be submitted for central review by day 7; for enrollment on AREN0534, unless a biopsy was done, the submission requirements at enrollment on AREN03B2 refer to imaging studies; tissue samples are only required if a surgical procedure (biopsy or nephrectomy) was performed at the time of enrollment on AREN03B2.
- - Patients must begin protocol therapy on AREN0534 by day 14 following surgery or diagnosis by initial computed tomography (CT)/magnetic resonance imaging (MRI), unless medically contraindicated.
- - Karnofsky performance status must be >= 50% for patients > 16 years of age and Lansky performance status must be >= 50% (for patients =< 16 years of age.
- - Patients must not have received systemic chemotherapy or radiation therapy prior to treatment on this study.
- - Patients with unilateral Wilms tumor and aniridia, Beckwith-Wiedemann Syndrome, idiopathic hemihypertrophy, Simpson-Golabi-Behmel-Syndrome, Denys-Drash Syndrome or other associated genitourinary anomalies; or multicentric or unilateral Wilms tumor with contralateral nephrogenic rest(s) (any size) in a child under 1 year of age who undergo a nephrectomy at diagnosis are not eligible for this study and should be directed to a unilateral Wilms tumor study.
- - Total bilirubin =< 1.5 times upper limit of normal (ULN) for age.
- - Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 times upper limit of normal (ULN) for age.
- - Shortening fraction >= 27% by echocardiogram, OR ejection fraction >= 50% by radionuclide angiogram.
- - (Cardiac function does not need to be assessed in patients who will not receive doxorubicin as part of their initial therapy on this study [i.e., patients who start on regimen EE-4A]) - Female patients of childbearing age must have a negative pregnancy test.
- - Female patients who are lactating must agree to stop breastfeeding.
- - Sexually active patients of childbearing potential must agree to use effective contraception.
- - All patients and/or their parents or legal guardians must sign a written informed consent.
- - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00945009 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Peter F Ehrlich |
| Principal Investigator Affiliation | Children's Oncology Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | Australia, Canada, Israel, New Zealand, Puerto Rico, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Adult Kidney Wilms Tumor, Beckwith-Wiedemann Syndrome, Childhood Kidney Wilms Tumor, Diffuse Hyperplastic Perilobar Nephroblastomatosis, Rhabdoid Tumor of the Kidney, Stage I Kidney Wilms Tumor, Stage II Kidney Wilms Tumor, Stage III Kidney Wilms Tumor, Stage IV Kidney Wilms Tumor, Stage V Kidney Wilms Tumor |
| Study Website: | View Trial Website |
OBJECTIVES:
- I. To improve 4-year event-free survival (EFS) to 73% for young patients with bilateral Wilms tumor (BWT).
- II. To prevent complete removal of at least one kidney in 50% of patients with BWT by using prenephrectomy 3-drug chemotherapy induction with vincristine (vincristine sulfate), dactinomycin, and doxorubicin (doxorubicin hydrochloride).
- III. To evaluate the efficacy of chemotherapy in preserving renal units in children with diffuse hyperplastic perilobar nephroblastomatosis (DHPLN) and preventing Wilms tumor development.
- IV. To facilitate partial nephrectomy in lieu of nephrectomy in 25% of children with unilateral tumors and aniridia, Beckwith-Wiedemann syndrome (BWS), hemihypertrophy or other overgrowth syndromes, by using prenephrectomy 2-drug chemotherapy induction with vincristine and dactinomycin.
- V. To have 75% of patients with BWT undergo definitive surgical treatment by 12 weeks after initiation of chemotherapy.
Arms
Experimental: Arm 1 (Bilateral Wilms Tumors)
Patients start with three drug chemotherapy (Regimen VAD; vincristine, dactinomycin and doxorubicin) and are evaluated and six and 12 weeks for feasibility of undergoing a partial nephrectomy/renal sparing surgery. At week 12 definitive surgery takes place followed by chemotherapy and radiation therapy based on histology and stage. Treatment continues for 25 or 31 weeks depending on histology. Patients are followed for up to 10 years following end of therapy.
Experimental: Arm 2 (Unilateral High Risk tumors bilaterally predisposed)
Patients start with either 2 drug or three drug chemotherapy (Regimen VA, VAD) and are evaluated a 6 and 12 weeks for feasibility of undergoing a partial nephrectomy. At week 12 definitive surgery takes place followed by chemotherapy.
Experimental: Arm 3 (DHPLN)
Patients with this rare disease are diagnosed based on cross-sectional imaging characteristics and undergo 2 drug chemotherapy (Regimen;VA). Patients are reassessed at 6 weeks and 12 weeks. If disease has responded or stayed stable chemotherapy is completed for 19 weeks (Regimen EE4A). If disease has progress a biopsy is performed to assess histology and adjust therapy based on the biopsy. This therapy may include, nephrectomy, chemotherapy or radiation therapy.
Interventions
Biological: - Dactinomycin
Given IV
Drug: - Doxorubicin Hydrochloride
Given IV
Radiation: - Radiation Therapy
Undergo radiation therapy
Procedure: - Therapeutic Conventional Surgery
Undergo surgical resection
Drug: - Vincristine Sulfate
Given IV
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Children's Hospital of Alabama
Birmingham 4049979, Alabama 4829764, 35233
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764, 35233
Status
Address
Phoenix Childrens Hospital
Phoenix 5308655, Arizona 5551752, 85016
Status
Address
Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752, 85719
Status
Address
Arkansas Children's Hospital
Little Rock 4119403, Arkansas 4099753, 72202-3591
Status
Address
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753, 72205
Status
Address
Kaiser Permanente Downey Medical Center
Downey 5343858, California 5332921, 90242
Status
Address
Loma Linda University Medical Center
Loma Linda 5367696, California 5332921, 92354
Status
Address
Miller Children's and Women's Hospital Long Beach
Long Beach 5367929, California 5332921, 90806
Status
Address
Children's Hospital Los Angeles
Los Angeles 5368361, California 5332921, 90027
Status
Address
Valley Children's Hospital
Madera 5369568, California 5332921, 93636
Status
Address
UCSF Benioff Children's Hospital Oakland
Oakland 5378538, California 5332921, 94609
Status
Address
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921, 94611
Status
Address
Children's Hospital of Orange County
Orange 5379513, California 5332921, 92868
Status
Address
Lucile Packard Children's Hospital Stanford University
Palo Alto 5380748, California 5332921, 94304
Status
Address
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921, 95817
Status
Address
Rady Children's Hospital - San Diego
San Diego 5391811, California 5332921, 92123
Status
Address
UCSF Medical Center-Parnassus
San Francisco 5391959, California 5332921, 94143
Status
Address
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921, 94158
Status
Address
Children's Hospital Colorado
Aurora 5412347, Colorado 5417618, 80045
Status
Address
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver 5419384, Colorado 5417618, 80218
Status
Address
Connecticut Children's Medical Center
Hartford 4835797, Connecticut 4831725, 06106
Status
Address
Alfred I duPont Hospital for Children
Wilmington 4145381, Delaware 4142224, 19803
Status
Address
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106, 20007
Status
Address
Children's National Medical Center
Washington D.C. 4140963, District of Columbia 4138106, 20010
Status
Address
Broward Health Medical Center
Fort Lauderdale 4155966, Florida 4155751, 33316
Status
Address
Lee Memorial Health System
Fort Myers 4155995, Florida 4155751, 33901
Status
Address
Golisano Children's Hospital of Southwest Florida
Fort Myers 4155995, Florida 4155751, 33908
Status
Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751, 33021
Status
Address
Nemours Children's Clinic-Jacksonville
Jacksonville 4160021, Florida 4155751, 32207
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Address
Miami Cancer Institute
Miami 4164138, Florida 4155751, 33176
Status
Address
AdventHealth Orlando
Orlando 4167147, Florida 4155751, 32803
Status
Address
Arnold Palmer Hospital for Children
Orlando 4167147, Florida 4155751, 32806
Status
Address
Nemours Children's Clinic - Orlando
Orlando 4167147, Florida 4155751, 32806
Status
Address
Orlando Health Cancer Institute
Orlando 4167147, Florida 4155751, 32806
Status
Address
Nemours Children's Hospital
Orlando 4167147, Florida 4155751, 32827
Status
Address
Nemours Children's Clinic - Pensacola
Pensacola 4168228, Florida 4155751, 32504
Status
Address
Johns Hopkins All Children's Hospital
St. Petersburg 4171563, Florida 4155751, 33701
Status
Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751, 33607
Status
Address
Saint Mary's Medical Center
West Palm Beach 4177887, Florida 4155751, 33407
Status
Address
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta 4180439, Georgia 4197000, 30329
Status
Address
Augusta University Medical Center
Augusta 4180531, Georgia 4197000, 30912
Status
Address
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000, 31404
Status
Address
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512, 83712
Status
Address
Lurie Children's Hospital-Chicago
Chicago 4887398, Illinois 4896861, 60611
Status
Address
Saint Jude Midwest Affiliate
Peoria 4905687, Illinois 4896861, 61637
Status
Address
Riley Hospital for Children
Indianapolis 4259418, Indiana 4921868, 46202
Status
Address
Blank Children's Hospital
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925, 40536
Status
Address
Norton Children's Hospital
Louisville 4299276, Kentucky 6254925, 40202
Status
Address
Tulane University School of Medicine
New Orleans 4335045, Louisiana 4331987, 70112
Status
Address
Children's Hospital New Orleans
New Orleans 4335045, Louisiana 4331987, 70118
Status
Address
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068, 04401
Status
Address
Maine Children's Cancer Program
Scarborough 4977882, Maine 4971068, 04074
Status
Address
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885, 21201
Status
Address
Sinai Hospital of Baltimore
Baltimore 4347778, Maryland 4361885, 21215
Status
Address
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885, 20889-5600
Status
Address
Tufts Children's Hospital
Boston 4930956, Massachusetts 6254926, 02111
Status
Address
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926, 02215
Status
Address
C S Mott Children's Hospital
Ann Arbor 4984247, Michigan 5001836, 48109
Status
Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
Status
Address
Michigan State University Clinical Center
East Lansing 4991640, Michigan 5001836, 48824
Status
Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
Status
Address
Kalamazoo Center for Medical Studies
Kalamazoo 4997787, Michigan 5001836, 49008
Status
Address
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis 5037649, Minnesota 5037779, 55404
Status
Address
University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779, 55455
Status
Address
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779, 55905
Status
Address
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296, 39216
Status
Address
Children's Mercy Hospitals and Clinics
Kansas City 4393217, Missouri 4398678, 64108
Status
Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
Status
Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
Status
Address
Sunrise Hospital and Medical Center
Las Vegas 5506956, Nevada 5509151, 89109
Status
Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151, 89135
Status
Address
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151, 89144
Status
Address
Nevada Cancer Research Foundation NCORP
Las Vegas 5506956, Nevada 5509151, 89169
Status
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174, 03756
Status
Address
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760, 07601
Status
Address
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760, 07039
Status
Address
Morristown Medical Center
Morristown 5101427, New Jersey 5101760, 07960
Status
Address
Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760, 08901
Status
Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick 5101717, New Jersey 5101760, 08903
Status
Address
Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760, 07112
Status
Address
Overlook Hospital
Summit 5105127, New Jersey 5101760, 07902
Status
Address
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136, 87106
Status
Address
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638, 14263
Status
Address
NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638, 11501
Status
Address
Mount Sinai Hospital
New York 5128581, New York 5128638, 10029
Status
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638, 10032
Status
Address
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638, 10065
Status
Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
Status
Address
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638, 13210
Status
Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
Status
Address
Mission Hospital
Asheville 4453066, North Carolina 4482348, 28801
Status
Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348, 27599
Status
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348, 28203
Status
Address
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348, 28204
Status
Address
Duke University Medical Center
Durham 4464368, North Carolina 4482348, 27710
Status
Address
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348, 27157
Status
Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Address
Children's Hospital Medical Center of Akron
Akron 5145476, Ohio 5165418, 44308
Status
Address
Cincinnati Children's Hospital Medical Center
Cincinnati 4508722, Ohio 5165418, 45229
Status
Address
Rainbow Babies and Childrens Hospital
Cleveland 5150529, Ohio 5165418, 44106
Status
Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
Status
Address
Nationwide Children's Hospital
Columbus 4509177, Ohio 5165418, 43205
Status
Address
Dayton Children's Hospital
Dayton 4509884, Ohio 5165418, 45404
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
Status
Address
Mercy Children's Hospital
Toledo 5174035, Ohio 5165418, 43608
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Address
Legacy Emanuel Children's Hospital
Portland 5746545, Oregon 5744337, 97227
Status
Address
Legacy Emanuel Hospital and Health Center
Portland 5746545, Oregon 5744337, 97227
Status
Address
Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927, 18017
Status
Address
Penn State Children's Hospital
Hershey 5193342, Pennsylvania 6254927, 17033
Status
Address
Children's Hospital of Philadelphia
Philadelphia 4560349, Pennsylvania 6254927, 19104
Status
Address
Saint Christopher's Hospital for Children
Philadelphia 4560349, Pennsylvania 6254927, 19134
Status
Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh 5206379, Pennsylvania 6254927, 15224
Status
Address
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040, 29203
Status
Address
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Greenville Cancer Treatment Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Address
East Tennessee Childrens Hospital
Knoxville 4634946, Tennessee 4662168, 37916
Status
Address
Saint Jude Children's Research Hospital
Memphis 4641239, Tennessee 4662168, 38105
Status
Address
Texas Tech University Health Sciences Center-Amarillo
Amarillo 5516233, Texas 4736286, 79106
Status
Address
Driscoll Children's Hospital
Corpus Christi 4683416, Texas 4736286, 78411
Status
Address
Medical City Dallas Hospital
Dallas 4684888, Texas 4736286, 75230
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286, 75390
Status
Address
Brooke Army Medical Center
Fort Sam Houston 7267736, Texas 4736286, 78234
Status
Address
Cook Children's Medical Center
Fort Worth 4691930, Texas 4736286, 76104
Status
Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286, 77030
Status
Address
Covenant Children's Hospital
Lubbock 5525577, Texas 4736286, 79410
Status
Address
Methodist Children's Hospital of South Texas
San Antonio 4726206, Texas 4736286, 78229
Status
Address
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286, 78229
Status
Address
Primary Children's Hospital
Salt Lake City 5780993, Utah 5549030, 84113
Status
Address
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283, 05405
Status
Address
University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928, 22908
Status
Address
Children's Hospital of The King's Daughters
Norfolk 4776222, Virginia 6254928, 23507
Status
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Address
Seattle Children's Hospital
Seattle 5809844, Washington 5815135, 98105
Status
Address
Providence Sacred Heart Medical Center and Children's Hospital
Spokane 5811696, Washington 5815135, 99204
Status
Address
Mary Bridge Children's Hospital and Health Center
Tacoma 5812944, Washington 5815135, 98405
Status
Address
Madigan Army Medical Center
Tacoma 5812944, Washington 5815135, 98431
Status
Address
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850, 25304
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468, 54301
Status
Address
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Children's Hospital of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
International Sites
Status
Address
Sydney Children's Hospital
Randwick 2208285, New South Wales 2155400, 2031
Status
Address
The Children's Hospital at Westmead
Westmead 2143973, New South Wales 2155400, 2145
Status
Address
Royal Brisbane and Women's Hospital
Herston 6931014, Queensland 2152274, 4029
Status
Address
Royal Children's Hospital-Brisbane
Herston 6931014, Queensland 2152274, 4029
Status
Address
Queensland Children's Hospital
South Brisbane 2207259, Queensland 2152274, 4101
Status
Address
Women's and Children's Hospital-Adelaide
North Adelaide 8469169, South Australia 2061327, 5006
Status
Address
Princess Margaret Hospital for Children
Perth 2063523, Western Australia 2058645, 6008
Status
Address
Alberta Children's Hospital
Calgary 5913490, Alberta 5883102, T3B 6A8
Status
Address
British Columbia Children's Hospital
Vancouver 6173331, British Columbia 5909050, V6H 3V4
Status
Address
CancerCare Manitoba
Winnipeg 6183235, Manitoba 6065171, R3E 0V9
Status
Address
IWK Health Centre
Halifax 6324729, Nova Scotia 6091530, B3K 6R8
Status
Address
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton 5969782, Ontario 6093943, L8N 3Z5
Status
Address
Kingston Health Sciences Centre
Kingston 5992500, Ontario 6093943, K7L 2V7
Status
Address
Children's Hospital of Eastern Ontario
Ottawa 6094817, Ontario 6093943, K1H 8L1
Status
Address
Hospital for Sick Children
Toronto 6167865, Ontario 6093943, M5G 1X8
Status
Address
The Montreal Children's Hospital of the MUHC
Montreal 6077243, Quebec 6115047, H3H 1P3
Status
Address
Centre Hospitalier Universitaire Sainte-Justine
Montreal 6077243, Quebec 6115047, H3T 1C5
Status
Address
Saskatoon Cancer Centre
Saskatoon 6141256, Saskatchewan 6141242, S7N 4H4
Status
Address
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec 6325494, , G1V 4G2
Status
Address
Schneider Children's Medical Center of Israel
Petah Tikua, , 49202
Status
Address
Starship Children's Hospital
Grafton 6232401, Auckland 2193734, 1145
Status
Address
Christchurch Hospital
Christchurch 2192362, , 8011
Status
Address
San Jorge Children's Hospital
San Juan 4568127, , 00912
