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Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma
Study Purpose
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with or without temozolomide in treating patients with low-grade glioma. PURPOSE: This randomized phase III trial is studying radiation therapy so see how well it works when given together with or without temozolomide in treating patients with low-grade glioma.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
DISEASE CHARACTERISTICS:
- - Histologically confirmed* supratentorial low-grade glioma, including 1 of the following: - Grade 2 astrocytoma.
- - Grade 2 oligodendroglioma.
- - Grade 2 oligoastrocytoma (mixed glioma containing astrocytoma and oligodendroglioma) - NOTE: *If the pathology from multiple procedures supports the diagnosis of a brain tumor, the qualifying pathology of grade 2 astrocytoma, oligodendroglioma, or oligoastrocytoma must be the most recent pathological diagnosis; no pathological diagnosis of grade 3 or 4 glioma at any time.
- - Paraffin-embedded tumor specimen available for submission for confirmation of pathological review and determination of 1p and 19q deletion status.
- - Patients must currently meet ≥ 1 of the following criteria*: - Uncontrolled symptoms, defined as any of the following: - Headaches associated with mass effect.
- - Uncontrolled seizures despite two different antiepileptic drug regimens (i.e., two antiepileptic drugs tested either sequentially or in combination) - Focal neurological symptoms.
- - Cognitive symptoms or deficits.
- - Tumor progression by serial MRIs, defined as any of the following: - New or progressive enhancement.
- - New or progressive T2 or FLAIR signal abnormality.
- - Age ≥ 40 years.
- - NOTE: *Patients < 40 years of age whose only symptom of low-grade glioma is seizures that are well-controlled on antiepileptic drugs AND who have no evidence of radiographic progression are not eligible.
- - Patients who have undergone gross total resection and have no detectable residual disease are eligible.
- - No pilocytic astrocytoma, ganglioglioma, pleomorphic xanthoastrocytoma, or dysembryoplastic neuroepithelial tumors.
- - Karnofsky performance status 60-100% - WBC ≥ 3,000/mm^3.
- - ANC ≥ 1,500/mm^3.
- - Platelet count ≥ 100,000/mm^3.
- - Hematocrit ≥ 30% - Bilirubin ≤ 2 times upper limit of normal (ULN) - AST and ALT ≤ 3 times ULN.
- - Creatinine ≤ 2.0 times ULN.
- - Not pregnant or nursing.
- - Negative pregnancy test.
- - Able to undergo MRI with and without contrast.
- - No other malignancy within the past 5 years, except for nonmelanoma skin cancer or cervical carcinoma in situ.
- - No uncontrolled infection.
- - No known HIV positivity.
- - No medical disorder that would increase risks associated with radiotherapy and temozolomide.
- - No other disorder that would limit life expectancy to < 5 years.
- - No prior radiotherapy, cytotoxic chemotherapy, radiosurgery, or investigational therapy directed at the brain tumor.
- - Any number of prior surgical procedures for the brain tumor allowed.
- - No prior radiotherapy to the head unless the radiotherapy ports entirely excluded the brain.
- - At least 2 weeks since any prior brain surgery (e.g., stereotatic biopsy, open biopsy, or resection) - At least 6 weeks since prior MRI and chest x-ray.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT00978458 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Eastern Cooperative Oncology Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
David Schiff, MD |
| Principal Investigator Affiliation | University of Virginia |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Brain and Central Nervous System Tumors, Neurotoxicity |
OBJECTIVES: Primary.
- - To determine whether the addition of temozolomide to fractionated radiotherapy improves the progression-free survival (PFS) of patients with symptomatic or progressive low-grade gliomas.
- - To determine whether the addition of temozolomide to fractionated radiotherapy improves the median overall survival (OS) of these patients.
- - To determine whether combination therapy with temozolomide and radiotherapy improves or maintains cognition and quality of life compared to radiotherapy alone.
- - To compare the toxicities (severe or worse [≥ grade 3]) of radiotherapy with vs.#46; without temozolomide in these patients.
- - To assess the impact of the presence or absence of 1p and 19q deletion on PFS and OS.
- - To determine the impact of 1p and 19q status on PFS and OS of patients treated with temozolomide.
- - To create a tumor and tissue bank, including plasma and germ line DNA, within the ECOG Pathology Coordinating Office.
- - Arm I: Patients undergo 3-dimensional conformal or intensity-modulated radiotherapy once daily 5 days a week for 5½ weeks (28 fractions).
- - Arm II: Patients undergo radiotherapy as in arm I and receive concurrent oral temozolomide once daily for 5½ weeks.
Arms
Active Comparator: Arm I
Patients undergo 3-dimensional conformal or intensity-modulated radiotherapy once daily 5 days a week for 5½ weeks (28 fractions).
Experimental: Arm II
Patients undergo radiotherapy as in arm I and receive concurrent oral temozolomide once daily for 5½ weeks. Beginning 28 days after completion of chemoradiotherapy, patients receive oral temozolomide alone once daily on days 1-5. Treatment with temozolomide repeats every 28 days for 12 courses in the absence of disease progression or unacceptable toxicity.
Interventions
Drug: - temozolomide
Given orally
Radiation: - 3-dimensional conformal radiation therapy
Given once daily 5 days a week for 5½ weeks
Radiation: - intensity-modulated radiation therapy
Given once daily 5 days a week for 5½ weeks
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
UAB Comprehensive Cancer Center
Birmingham 4049979, Alabama 4829764, 35294
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Address
Arizona Oncology Services Foundation
Phoenix 5308655, Arizona 5551752, 85013
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Address
Rebecca and John Moores UCSD Cancer Center
La Jolla 5363943, California 5332921, 92093-0658
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Address
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Orange 5379513, California 5332921, 92868
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Address
Aurora Presbyterian Hospital
Aurora 5412347, Colorado 5417618, 80012
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Address
St. Anthony Central Hospital
Denver 5419384, Colorado 5417618, 80204
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Address
Porter Adventist Hospital
Denver 5419384, Colorado 5417618, 80210
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Address
Presbyterian - St. Luke's Medical Center
Denver 5419384, Colorado 5417618, 80218
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Address
St. Joseph Hospital
Denver 5419384, Colorado 5417618, 80218
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Address
CCOP - Colorado Cancer Research Program
Denver 5419384, Colorado 5417618, 80222
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Address
Swedish Medical Center
Englewood 5421250, Colorado 5417618, 80110
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Address
Sky Ridge Medical Center
Lone Tree 5429208, Colorado 5417618, 80124
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Address
Eastern Connecticut Hematology and Oncology Associates
Norwich 4839843, Connecticut 4831725, 06360
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Address
CCOP - Christiana Care Health Services
Newark 4143861, Delaware 4142224, 19713
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Address
Mayo Clinic - Jacksonville
Jacksonville 4160021, Florida 4155751, 32224
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Address
Florida Hospital Cancer Institute at Florida Hospital Orlando
Orlando 4167147, Florida 4155751, 32803-1273
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Address
Winship Cancer Institute of Emory University
Atlanta 4180439, Georgia 4197000, 30322
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Address
Illinois CancerCare - Bloomington
Bloomington 4885164, Illinois 4896861, 61701
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Address
St. Joseph Medical Center
Bloomington 4885164, Illinois 4896861, 61701
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Address
Graham Hospital
Canton 4831990, Illinois 4896861, 61520
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Address
Illinois CancerCare - Canton
Canton 4831990, Illinois 4896861, 61520
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Address
Illinois CancerCare - Carthage
Carthage 4886716, Illinois 4896861, 62321
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Address
Memorial Hospital
Carthage 4886716, Illinois 4896861, 62321
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Address
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago 4887398, Illinois 4896861, 60611-3013
Status
Address
John H. Stroger, Jr. Hospital of Cook County
Chicago 4887398, Illinois 4896861, 60612-3785
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Address
University of Illinois Cancer Center
Chicago 4887398, Illinois 4896861, 60612-7243
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Address
University of Chicago Cancer Research Center
Chicago 4887398, Illinois 4896861, 60637-1470
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Address
Decatur Memorial Hospital Cancer Care Institute
Decatur 4236895, Illinois 4896861, 62526
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Address
Eureka Community Hospital
Eureka 4891310, Illinois 4896861, 61530
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Address
Illinois CancerCare - Eureka
Eureka 4891310, Illinois 4896861, 61530
Status
Address
Evanston Hospital
Evanston 4891382, Illinois 4896861, 60201-1781
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Address
Galesburg Clinic, PC
Galesburg 4893392, Illinois 4896861, 61401
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Address
Illinois CancerCare - Havana
Havana 4895336, Illinois 4896861, 62644
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Address
Illinois CancerCare - Kewanee Clinic
Kewanee 4898433, Illinois 4896861, 61443
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Address
La Grange Memorial Hospital
La Grange 4898846, Illinois 4896861, 60525
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Address
Illinois CancerCare - Macomb
Macomb 4900817, Illinois 4896861, 61455
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Address
McDonough District Hospital
Macomb 4900817, Illinois 4896861, 61455
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Address
Illinois CancerCare - Monmouth
Monmouth 4902512, Illinois 4896861, 61462
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Address
OSF Holy Family Medical Center
Monmouth 4902512, Illinois 4896861, 61462
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Address
BroMenn Regional Medical Center
Normal 4903780, Illinois 4896861, 61761
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Address
Community Cancer Center
Normal 4903780, Illinois 4896861, 61761
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Address
Illinois CancerCare - Community Cancer Center
Normal 4903780, Illinois 4896861, 61761
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Address
Community Hospital of Ottawa
Ottawa 4905006, Illinois 4896861, 61350
Status
Address
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa 4905006, Illinois 4896861, 61350
Status
Address
Cancer Treatment Center at Pekin Hospital
Pekin 4905599, Illinois 4896861, 61554
Status
Address
Illinois CancerCare - Pekin
Pekin 4905599, Illinois 4896861, 61603
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Address
Proctor Hospital
Peoria 4905687, Illinois 4896861, 61614
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Address
OSF St. Francis Medical Center
Peoria 4905687, Illinois 4896861, 61615-7827
Status
Address
CCOP - Illinois Oncology Research Association
Peoria 4905687, Illinois 4896861, 61615
Status
Address
Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria 4905687, Illinois 4896861, 61615
Status
Address
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861, 61636
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Address
Illinois CancerCare - Peru
Peru 4905770, Illinois 4896861, 61354
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Address
Illinois Valley Community Hospital
Peru 4905770, Illinois 4896861, 61354
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Address
Illinois CancerCare - Princeton
Princeton 4906818, Illinois 4896861, 61356
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Address
Illinois CancerCare - Spring Valley
Spring Valley 4912303, Illinois 4896861, 61362
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Address
Valley Cancer Center
Spring Valley 4912303, Illinois 4896861, 61362
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Address
Elkhart General Hospital
Elkhart 4919987, Indiana 4921868, 46515
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Address
Radiation Oncology Associates Southwest
Fort Wayne 4920423, Indiana 4921868, 46804
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Address
Parkview Regional Cancer Center at Parkview Health
Fort Wayne 4920423, Indiana 4921868, 46805
Status
Address
Community Regional Cancer Care at Community Hospital East
Indianapolis 4259418, Indiana 4921868, 46219
Status
Address
Community Regional Cancer Care at Community Hospital North
Indianapolis 4259418, Indiana 4921868, 46256
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Address
Howard Community Hospital
Kokomo 4922388, Indiana 4921868, 46904
Status
Address
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte 8449910, Indiana 4921868, 46350
Status
Address
Michiana Hematology-Oncology, PC - South Bend
Mishawaka 4923670, Indiana 4921868, 46545-1470
Status
Address
CCOP - Northern Indiana CR Consortium
South Bend 4926563, Indiana 4921868, 46601
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Address
Memorial Hospital of South Bend
South Bend 4926563, Indiana 4921868, 46601
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Address
CCOP - Iowa Oncology Research Association
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City 4866445, Iowa 4862182, 50401
Status
Address
Siouxland Hematology-Oncology Associates, LLP
Sioux City 4876523, Iowa 4862182, 51101
Status
Address
Cancer Center of Kansas, PA - Wellington
Wellington 4281386, Kansas 4273857, 67152
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Address
Cancer Center of Kansas, PA - Wichita
Wichita 4281730, Kansas 4273857, 67214
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Address
CCOP - Wichita
Wichita 4281730, Kansas 4273857, 67214
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Address
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita 4281730, Kansas 4273857, 67214
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Address
Cancer Center of Kansas, PA - Winfield
Winfield 4281897, Kansas 4273857, 67156
Status
Address
Louisville Oncology at Norton Cancer Institute - Louisville
Louisville 4299276, Kentucky 6254925, 40202
Status
Address
Norton Suburban Hospital
Louisville 4299276, Kentucky 6254925, 40207
Status
Address
Maine Center for Cancer Medicine and Blood Disorders - Scarborough
Scarborough 4977882, Maine 4971068, 04074
Status
Address
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore 4347778, Maryland 4361885, 21231-2410
Status
Address
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit 4990729, Michigan 5001836, 48202
Status
Address
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836, 48503
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Address
Hurley Medical Center
Flint 4992982, Michigan 5001836, 48503
Status
Address
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836, 49007-3731
Status
Address
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph 5008327, Michigan 5001836, 49085
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Address
Lakeside Cancer Specialists, PLLC
Saint Joseph 5008327, Michigan 5001836, 49085
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Address
Fairview Ridges Hospital
Burnsville 5019767, Minnesota 5037779, 55337
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Address
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779, 55433
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Address
CCOP - Duluth
Duluth 5024719, Minnesota 5037779, 55805
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Address
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779, 55435
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Address
Mercy and Unity Cancer Center at Unity Hospital
Fridley 5027482, Minnesota 5037779, 55432
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Address
Hutchinson Area Health Care
Hutchinson 5030977, Minnesota 5037779, 55350
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Address
HealthEast Cancer Care at St. John's Hospital
Maplewood 5036588, Minnesota 5037779, 55109
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Address
Minnesota Oncology - Maplewood
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779, 55407
Status
Address
Hennepin County Medical Center - Minneapolis
Minneapolis 5037649, Minnesota 5037779, 55415
Status
Address
Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale 5043439, Minnesota 5037779, 55422-2900
Status
Address
Mayo Clinic Cancer Center
Rochester 5043473, Minnesota 5037779, 55905
Status
Address
CCOP - Metro-Minnesota
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Park Nicollet Cancer Center
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Regions Hospital Cancer Care Center
Saint Paul 5045360, Minnesota 5037779, 55101
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Address
United Hospital
Saint Paul 5045360, Minnesota 5037779, 55102
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Address
St. Francis Cancer Center at St. Francis Medical Center
Shakopee 5046997, Minnesota 5037779, 55379
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Address
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779, 55082
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Address
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779, 55387
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Address
Willmar Cancer Center at Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779, 56201
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Address
Minnesota Oncology - Woodbury
Woodbury 5053358, Minnesota 5037779, 55125
Status
Address
Billings Clinic - Downtown
Billings 5640350, Montana 5667009, 59107-7000
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Address
Cancer Resource Center - Lincoln
Lincoln 5072006, Nebraska 5073708, 68510
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Address
CCOP - Missouri Valley Cancer Consortium
Omaha 5074472, Nebraska 5073708, 68106
Status
Address
Methodist Estabrook Cancer Center
Omaha 5074472, Nebraska 5073708, 68114
Status
Address
Nebraska Medical Center
Omaha 5074472, Nebraska 5073708, 68198
Status
Address
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon 5088597, New Hampshire 5090174, 03756-0002
Status
Address
New York Oncology Hematology, PC at Albany Medical Center
Albany 5106834, New York 5128638, 12208
Status
Address
Memorial Sloan-Kettering Cancer Center
New York 5128581, New York 5128638, 10065
Status
Address
SUNY Upstate Medical University Hospital
Syracuse 5140405, New York 5128638, 13210
Status
Address
Mission Hospitals - Memorial Campus
Asheville 4453066, North Carolina 4482348, 28801
Status
Address
Wake Forest University Comprehensive Cancer Center
Winston-Salem 4499612, North Carolina 4482348, 27157-1096
Status
Address
Summa Center for Cancer Care at Akron City Hospital
Akron 5145476, Ohio 5165418, 44309-2090
Status
Address
Barberton Citizens Hospital
Barberton 5146491, Ohio 5165418, 44203
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Address
Charles M. Barrett Cancer Center at University Hospital
Cincinnati 4508722, Ohio 5165418, 45267
Status
Address
Case Comprehensive Cancer Center
Cleveland 5150529, Ohio 5165418, 44106-5065
Status
Address
Cleveland Clinic Taussig Cancer Center
Cleveland 5150529, Ohio 5165418, 44195
Status
Address
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418, 43210-1240
Status
Address
Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337, 97030
Status
Address
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland 5746545, Oregon 5744337, 97210
Status
Address
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown 5178127, Pennsylvania 6254927, 18105
Status
Address
St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem 5180225, Pennsylvania 6254927, 18015
Status
Address
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia 4560349, Pennsylvania 6254927, 19107-5541
Status
Address
Hollings Cancer Center at Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Address
Cancer Centers of the Carolinas - Faris Road
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Cancer Centers of the Carolinas - Grove Commons
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Cancer Centers of the Carolinas - Eastside
Greenville 4580543, South Carolina 4597040, 29615
Status
Address
CCOP - Greenville
Greenville 4580543, South Carolina 4597040, 29615
Status
Address
Cancer Centers of the Carolinas - Greer Medical Oncology
Greer 4580599, South Carolina 4597040, 29650
Status
Address
Cancer Centers of the Carolinas - Greer Radiation Oncology
Greer 4580599, South Carolina 4597040, 29650
Status
Address
Cancer Centers of the Carolinas - Seneca
Seneca 4595346, South Carolina 4597040, 29672
Status
Address
CCOP - Upstate Carolina
Spartanburg 4597200, South Carolina 4597040, 29303
Status
Address
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg 4597200, South Carolina 4597040, 29303
Status
Address
Cancer Centers of the Carolinas - Spartanburg
Spartanburg 4597200, South Carolina 4597040, 29307
Status
Address
Rapid City Regional Hospital
Rapid City 5768233, South Dakota 5769223, 57701
Status
Address
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls 5231851, South Dakota 5769223, 57117-5039
Status
Address
Vanderbilt-Ingram Cancer Center
Nashville 4644585, Tennessee 4662168, 37232-6838
Status
Address
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
Dallas 4684888, Texas 4736286, 75390
Status
Address
University of Texas Medical Branch
Galveston 4692883, Texas 4736286, 77555-0361
Status
Address
M. D. Anderson Cancer Center at University of Texas
Houston 4699066, Texas 4736286, 77030-4009
Status
Address
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
Murray 5778755, Utah 5549030, 84157
Status
Address
Utah Valley Regional Medical Center - Provo
Provo 5780026, Utah 5549030, 84604
Status
Address
Dixie Regional Medical Center - East Campus
St. George 5546220, Utah 5549030, 84770
Status
Address
Virginia Commonwealth University Massey Cancer Center
Richmond 4781708, Virginia 6254928, 23298-0037
Status
Address
CCOP - Virginia Mason Research Center
Seattle 5809844, Washington 5815135, 98101
Status
Address
University Cancer Center at University of Washington Medical Center
Seattle 5809844, Washington 5815135, 98195
Status
Address
Legacy Salmon Creek Medical Center
Vancouver 5814616, Washington 5815135, 98686
Status
Address
Theda Care Cancer Institute
Appleton 5244080, Wisconsin 5279468, 54911
Status
Address
Marshfield Clinic Cancer Care at Regional Cancer Center
Eau Claire 5251436, Wisconsin 5279468, 54701
Status
Address
St. Vincent Hospital Regional Cancer Center
Green Bay 5254962, Wisconsin 5279468, 54307-3508
Status
Address
Gundersen Lutheran Center for Cancer and Blood
La Crosse 5258957, Wisconsin 5279468, 54601
Status
Address
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison 5261457, Wisconsin 5279468, 53792-6164
Status
Address
Marshfield Clinic - Marshfield Center
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Saint Joseph's Hospital
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Columbia Saint Mary's Hospital - Ozaukee
Mequon 5262649, Wisconsin 5279468, 53097
Status
Address
Columbia-Saint Mary's Cancer Care Center
Milwaukee 5263045, Wisconsin 5279468, 53211
Status
Address
Medical College of Wisconsin Cancer Center
Milwaukee 5263045, Wisconsin 5279468, 53226
Status
Address
Marshfield Clinic - Lakeland Center
Minocqua 5263156, Wisconsin 5279468, 54548
Status
Address
Ministry Medical Group at Saint Mary's Hospital
Rhinelander 5268720, Wisconsin 5279468, 54501
Status
Address
Marshfield Clinic - Indianhead Center
Rice Lake 5268798, Wisconsin 5279468, 54868
Status
Address
Marshfield Clinic at Saint Michael's Hospital
Stevens Point 5274644, Wisconsin 5279468, 54481
Status
Address
Waukesha Memorial Hospital Regional Cancer Center
Waukesha 5278052, Wisconsin 5279468, 53188
Status
Address
Diagnostic and Treatment Center
Weston 5278693, Wisconsin 5279468, 54476
Status
Address
Marshfield Clinic - Weston Center
Weston 5278693, Wisconsin 5279468, 54476
