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Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery
Study Purpose
This randomized phase II trial is studying how well giving ipilimumab with or without sargramostim (GM-CSF) works in treating patients with stage III or stage IV melanoma that cannot be removed by surgery (unresectable). Ipilimumab works by activating the patient's immune system to fight cancer. Colony-stimulating factors, such as sargramostim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of treatment. It is not yet known whether giving ipilimumab together with sargramostim is more effective than ipilimumab alone in treating melanoma.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - All sites of disease must be evaluated within 4 weeks prior to randomization; patients must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) - No more than one prior systemic therapeutic regimen for unresectable stage III or stage IV melanoma; this includes chemotherapy, biologic therapy, biochemotherapy, or investigational treatment; this does not include any therapies given in the adjuvant setting.
- - Histologic diagnosis of metastatic melanoma; for unknown primary disease, diagnosis of metastatic disease by cytology fine needle aspiration (FNA) is not acceptable.
- - Women must not be pregnant or breast-feeding due to unknown effects of ipilimumab and GM-CSF on the unborn fetus; all women of childbearing potential must have a blood test within 72 hours prior to randomization to rule out pregnancy; women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception; women of childbearing potential (WOCBP) must be using an adequate method of contraception to avoid pregnancy throughout the study and for up to 12 weeks after the last dose of investigational product, in such a manner that the risk of pregnancy is minimized; sexually mature females who have not undergone a hysterectomy or who have not been postmenopausal naturally for at least 24 consecutive months (i.e., who have had menses at some time in the preceding 24 consecutive months) are considered to be of childbearing potential; women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential.
- - White blood cells (WBC) >= 2000/uL (obtained =< 4 weeks prior to randomization) - Absolute neutrophil count (ANC) >= 1500/mcL (obtained =< 4 weeks prior to randomization) - Platelets >= 100,000/mcL (obtained =< 4 weeks prior to randomization) - Hemoglobin >= 8 g/dL (obtained =< 4 weeks prior to randomization) - Creatinine =< 3.0 x upper limit of normal (ULN) (obtained =< 4 weeks prior to randomization) - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN (obtained =< 4 weeks prior to randomization) - Bilirubin =< 3.0 x ULN, (except patients with Gilbert's syndrome, who must have a total bilirubin less than 3.0 mg/dL) (obtained =< 4 weeks prior to randomization) - No concomitant therapy with any of the following: interleukin (IL) 2, interferon, or other non-study immunotherapy regimens; cytotoxic chemotherapy; immunosuppressive agents; other investigation therapies; or chronic use of systemic corticosteroids; must have been discontinued >= 4 weeks.
- - No infection with human immunodeficiency virus (HIV); due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown.
- - No active infection with hepatitis B.
- - No active or chronic infection with hepatitis C.
- - Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
Exclusion Criteria:
- - Patients with any history of central nervous system (CNS) metastases are excluded.
- - Patients are excluded if they have a history of any other malignancy from which the patient has been disease-free for less than 2 years, with the exception of adequately treated and cured basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix.
- - Patients are excluded if they have a history of any autoimmune disease; patients with a history of autoimmune thyroiditis are eligible if their current thyroid disorder is treated and stable with replacement or other medical therapy.
- - Patients are excluded for any underlying medical or psychiatric condition, which in the opinion of the investigator, will make the administration of study drug hazardous or obscure the interpretation of adverse events, such as a condition associated with frequent diarrhea.
- - Patients are excluded for receiving any non-oncology vaccine therapy used for prevention of infectious diseases for up to four weeks (28 days) prior to or after any dose of ipilimumab.
- - Patients are excluded if they have a history of prior treatment with ipilimumab or prior cluster of differentiation (CD)137 agonist or cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor or agonist.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT01134614 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Frank S Hodi |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Advanced Melanoma, Metastatic Melanoma, Recurrent Melanoma, Stage III Cutaneous Melanoma AJCC v7, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7, Unresectable Melanoma |
PRIMARY OBJECTIVES:
- I. To evaluate the overall survival for the combination of sargramostim (GM-CSF) plus ipilimumab and ipilimumab alone in patients with advanced melanoma.
- I. To evaluate the progression-free survival, response rate, safety and tolerability for the combination of GM-CSF plus ipilimumab and ipilimumab alone in patients with advanced melanoma.
- II. To explore the utility of immune related response criteria (irRC) prospectively in patients receiving ipilimumab.
Arms
Experimental: Arm A (ipilimumab and sargramostim)
Patients receive induction therapy comprising ipilimumab IV over 90 minutes on day 1 and sargramostim SC once daily on days 1-14. Treatment repeats every 21 days for 4 cycles. After 12 weeks of induction treatment, anti-tumor response is assessed and patients then receive maintenance therapy comprising ipilimumab IV over 90 minutes on day 1 and sargramostim SC once daily on days 1-14. Treatment with ipilimumab repeats every 12 weeks and treatment with sargramostim repeats every 21 days. After 12 weeks of maintenance therapy, anti-tumor response is reassessed and patients with responsive or stable disease then continue maintenance therapy until disease progression or unacceptable toxicity.
Active Comparator: Arm B (ipilimumab)
Patients receive induction therapy comprising ipilimumab IV over 90 minutes on day 1. Treatment repeats every 21 days for 4 cycles. After 12 weeks of induction treatment, anti-tumor response is assessed and patients then receive maintenance therapy of ipilimumab IV over 90 minutes on day 1. Treatment with ipilimumab repeats every 12 weeks. After 12 weeks of maintenance therapy, anti-tumor response is reassessed and cycles repeat every 12 weeks in the absence of disease progression or unacceptable toxicity
Interventions
Biological: - Ipilimumab
Given IV
Biological: - Sargramostim
Given SC
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
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Stanford Cancer Institute Palo Alto
Palo Alto, California, 94304
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VA Palo Alto Health Care System
Palo Alto, California, 94304
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Address
Eisenhower Medical Center
Rancho Mirage, California, 92270
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Address
The Medical Center of Aurora
Aurora, Colorado, 80012
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Address
Boulder Community Foothills Hospital
Boulder, Colorado, 80303
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Address
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
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Address
AdventHealth Porter
Denver, Colorado, 80210
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Address
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218
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Address
Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado, 80218
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Address
Rose Medical Center
Denver, Colorado, 80220
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Address
Western States Cancer Research NCORP
Denver, Colorado, 80222
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Address
Swedish Medical Center
Englewood, Colorado, 80113
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Address
Poudre Valley Hospital
Fort Collins, Colorado, 80524
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Address
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81501
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Address
Banner North Colorado Medical Center
Greeley, Colorado, 80631
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Saint Anthony Hospital
Lakewood, Colorado, 80228
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Address
Sky Ridge Medical Center
Lone Tree, Colorado, 80124
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Address
Longmont United Hospital
Longmont, Colorado, 80501
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Address
Banner McKee Medical Center
Loveland, Colorado, 80539
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Address
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
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Address
North Suburban Medical Center
Thornton, Colorado, 80229
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Address
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401
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Address
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
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Address
Manchester Memorial Hospital
Manchester, Connecticut, 06040
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Address
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
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Address
Yale University
New Haven, Connecticut, 06520
Status
Address
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, 06360
Status
Address
Beebe Medical Center
Lewes, Delaware, 19958
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Address
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
Status
Address
Boca Raton Regional Hospital
Boca Raton, Florida, 33486
Status
Address
Lakeland Regional Health Hollis Cancer Center
Lakeland, Florida, 33805
Status
Address
21st Century Oncology-Orange Park
Orange Park, Florida, 32073
Status
Address
University Cancer and Blood Center LLC
Athens, Georgia, 30607
Status
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Status
Address
Augusta University Medical Center
Augusta, Georgia, 30912
Status
Address
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
Status
Address
Rush-Copley Medical Center
Aurora, Illinois, 60504
Status
Address
MacNeal Hospital and Cancer Center
Berwyn, Illinois, 60402
Status
Address
OSF Saint Joseph Medical Center
Bloomington, Illinois, 61701
Status
Address
Graham Hospital Association
Canton, Illinois, 61520
Status
Address
Memorial Hospital
Carthage, Illinois, 62321
Status
Address
Hematology and Oncology Associates
Chicago, Illinois, 60611
Status
Address
Northwestern University
Chicago, Illinois, 60611
Status
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Address
Decatur Memorial Hospital
Decatur, Illinois, 62526
Status
Address
Heartland Cancer Research NCORP
Decatur, Illinois, 62526
Status
Address
Eureka Hospital
Eureka, Illinois, 61530
Status
Address
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
Status
Address
Mason District Hospital
Havana, Illinois, 62644
Status
Address
Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, 60035
Status
Address
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale, Illinois, 60521
Status
Address
Duly Health and Care Joliet
Joliet, Illinois, 60435
Status
Address
Presence Saint Mary's Hospital
Kankakee, Illinois, 60901
Status
Address
AMG Libertyville - Oncology
Libertyville, Illinois, 60048
Status
Address
Mcdonough District Hospital
Macomb, Illinois, 61455
Status
Address
Trinity Medical Center
Moline, Illinois, 61265
Status
Address
DuPage Medical Group-Ogden
Naperville, Illinois, 60563
Status
Address
Illinois Cancer Specialists-Niles
Niles, Illinois, 60714
Status
Address
Carle BroMenn Medical Center
Normal, Illinois, 61761
Status
Address
Carle Cancer Institute Normal
Normal, Illinois, 61761
Status
Address
Ottawa Regional Hospital and Healthcare Center
Ottawa, Illinois, 61350
Status
Address
OSF Saint Francis Radiation Oncology at Pekin
Pekin, Illinois, 61554
Status
Address
Proctor Hospital
Peoria, Illinois, 61614
Status
Address
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Status
Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
Status
Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
Status
Address
Illinois Valley Hospital
Peru, Illinois, 61354
Status
Address
Perry Memorial Hospital
Princeton, Illinois, 61356
Status
Address
Swedish American Hospital
Rockford, Illinois, 61104
Status
Address
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
Status
Address
Hematology Oncology Associates of Illinois - Skokie
Skokie, Illinois, 60076
Status
Address
Springfield Memorial Hospital
Springfield, Illinois, 62781
Status
Address
Carle Cancer Center
Urbana, Illinois, 61801
Status
Address
Elkhart General Hospital
Elkhart, Indiana, 46515
Status
Address
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
Status
Address
Community Howard Regional Health
Kokomo, Indiana, 46904
Status
Address
IU Health La Porte Hospital
La Porte, Indiana, 46350
Status
Address
Franciscan Saint Anthony Health-Michigan City
Michigan City, Indiana, 46360
Status
Address
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka, Indiana, 46545
Status
Address
IU Health Ball Memorial Hospital
Muncie, Indiana, 47303
Status
Address
Memorial Hospital of South Bend
South Bend, Indiana, 46601
Status
Address
Northern Indiana Cancer Research Consortium
South Bend, Indiana, 46628
Status
Address
McFarland Clinic - Ames
Ames, Iowa, 50010
Status
Address
Mercy Hospital
Cedar Rapids, Iowa, 52403
Status
Address
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
Status
Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
Status
Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Status
Address
Iowa-Wide Oncology Research Coalition NCORP
Des Moines, Iowa, 50309
Status
Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
Status
Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Status
Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
Status
Address
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
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Address
Mercy Medical Center - North Iowa
Mason City, Iowa, 50401
Status
Address
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101
Status
Address
Mercy Medical Center-Sioux City
Sioux City, Iowa, 51102
Status
Address
Saint Luke's Regional Medical Center
Sioux City, Iowa, 51104
Status
Address
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720
Status
Address
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
Status
Address
Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042
Status
Address
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068
Status
Address
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
Status
Address
Cancer Center of Kansas-Liberal
Liberal, Kansas, 67905
Status
Address
Cancer Center of Kansas - Newton
Newton, Kansas, 67114
Status
Address
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357
Status
Address
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124
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Address
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
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Address
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
Status
Address
Associates In Womens Health
Wichita, Kansas, 67208
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
Status
Address
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
Status
Address
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
Status
Address
Wichita NCI Community Oncology Research Program
Wichita, Kansas, 67214
Status
Address
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
Status
Address
Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky, 42303
Status
Address
Ochsner Health Center-Summa
Baton Rouge, Louisiana, 70809
Status
Address
Ochsner Health Center-Covington
Covington, Louisiana, 70433
Status
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Status
Address
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
Status
Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
Status
Address
Christiana Care - Union Hospital
Elkton, Maryland, 21921
Status
Address
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Status
Address
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
Status
Address
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Status
Address
Baystate Medical Center
Springfield, Massachusetts, 01199
Status
Address
Michigan Cancer Research Consortium NCORP
Ann Arbor, Michigan, 48106
Status
Address
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
Status
Address
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
Status
Address
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
Status
Address
Hurley Medical Center
Flint, Michigan, 48503
Status
Address
Genesys Regional Medical Center-West Flint Campus
Flint, Michigan, 48532
Status
Address
Allegiance Health
Jackson, Michigan, 49201
Status
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Status
Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Status
Address
Beacon Kalamazoo
Kalamazoo, Michigan, 49048
Status
Address
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
Status
Address
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
Status
Address
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan, 48341
Status
Address
Lake Huron Medical Center
Port Huron, Michigan, 48060
Status
Address
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
Status
Address
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
Status
Address
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
Status
Address
Henry Ford Health Warren Hospital
Warren, Michigan, 48093
Status
Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Status
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Status
Address
Essentia Health Cancer Center
Duluth, Minnesota, 55805
Status
Address
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
Status
Address
Miller-Dwan Hospital
Duluth, Minnesota, 55805
Status
Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
Status
Address
Unity Hospital
Fridley, Minnesota, 55432
Status
Address
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Status
Address
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Status
Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Status
Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Status
Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Status
Address
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota, 55416
Status
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Status
Address
Regions Hospital
Saint Paul, Minnesota, 55101
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Address
United Hospital
Saint Paul, Minnesota, 55102
Status
Address
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Status
Address
Lakeview Hospital
Stillwater, Minnesota, 55082
Status
Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
Status
Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Address
Nebraska Cancer Research Center
Lincoln, Nebraska, 68510
Status
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131
Status
Address
Nevada Cancer Research Foundation NCORP
Las Vegas, Nevada, 89120
Status
Address
Nevada Cancer Institute-Summerlin Campus
Las Vegas, Nevada, 89135
Status
Address
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
Status
Address
Hunterdon Medical Center
Flemington, New Jersey, 08822
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Morristown Medical Center
Morristown, New Jersey, 07960
Status
Address
Virtua Memorial
Mount Holly, New Jersey, 08060
Status
Address
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Status
Address
Overlook Hospital
Summit, New Jersey, 07902
Status
Address
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
Status
Address
Presbyterian Kaseman Hospital
Albuquerque, New Mexico, 87110
Status
Address
San Juan Oncology Associates
Farmington, New Mexico, 87401
Status
Address
New York Oncology Hematology PC - Albany Medical Center
Albany, New York, 12208
Status
Address
Mary Imogene Bassett Hospital
Cooperstown, New York, 13326
Status
Address
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
Status
Address
Stony Brook University Medical Center
Stony Brook, New York, 11794
Status
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Address
Summa Health System - Akron Campus
Akron, Ohio, 44304
Status
Address
Cleveland Clinic Mercy Hospital
Canton, Ohio, 44708
Status
Address
Aultman Health Foundation
Canton, Ohio, 44710
Status
Address
The Christ Hospital
Cincinnati, Ohio, 45219
Status
Address
Case Western Reserve University
Cleveland, Ohio, 44106
Status
Address
MetroHealth Medical Center
Cleveland, Ohio, 44109
Status
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Address
Saint Rita's Medical Center
Lima, Ohio, 45801
Status
Address
Saint Charles Hospital
Oregon, Ohio, 43616
Status
Address
ProMedica Flower Hospital
Sylvania, Ohio, 43560
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
Status
Address
Mercy Health - Saint Vincent Hospital
Toledo, Ohio, 43608
Status
Address
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Status
Address
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015
Status
Address
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, 19010
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
Doylestown Hospital
Doylestown, Pennsylvania, 18901
Status
Address
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Status
Address
Saint Mary Medical and Regional Cancer Center
Langhorne, Pennsylvania, 19047
Status
Address
Paoli Memorial Hospital
Paoli, Pennsylvania, 19301
Status
Address
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Status
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
Status
Address
Pottstown Hospital
Pottstown, Pennsylvania, 19464
Status
Address
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania, 18840
Status
Address
Hematology and Oncology Associates of North East Pennsylvania
Scranton, Pennsylvania, 18508
Status
Address
Reading Hospital
West Reading, Pennsylvania, 19611
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
Lankenau Medical Center
Wynnewood, Pennsylvania, 19096
Status
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Status
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Status
Address
Medical X-Ray Center
Sioux Falls, South Dakota, 57105
Status
Address
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, 57117-5045
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Address
Erlanger Medical Center
Chattanooga, Tennessee, 37403
Status
Address
Jackson-Madison County General Hospital
Jackson, Tennessee, 38301
Status
Address
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Status
Address
Parkland Memorial Hospital
Dallas, Texas, 75235
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Status
Address
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
Status
Address
West Virginia University Charleston Division
Charleston, West Virginia, 25304
Status
Address
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Status
Address
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia, 26003
Status
Address
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
Status
Address
ThedaCare Regional Cancer Center
Appleton, Wisconsin, 54911
Status
Address
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin, 54729
Status
Address
Marshfield Clinic Cancer Center at Sacred Heart
Eau Claire, Wisconsin, 54701
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
Status
Address
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
Status
Address
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin, 53548
Status
Address
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin, 53038
Status
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
SSM Health Dean Medical Group - South Madison Campus
Madison, Wisconsin, 53715
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Status
Address
Holy Family Memorial Hospital
Manitowoc, Wisconsin, 54221
Status
Address
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
Status
Address
Bay Area Medical Center
Marinette, Wisconsin, 54143
Status
Address
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Status
Address
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
Status
Address
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
Status
Address
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin, 54501
Status
Address
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Status
Address
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin, 53081
Status
Address
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
Status
Address
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin, 54481
Status
Address
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
Status
Address
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
Status
Address
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
Status
Address
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
Status
Address
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
Status
Address
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
Status
Address
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494
