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Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
Study Purpose
This randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, may block tumor growth by targeting certain cells. Recombinant interferon alfa-2b may interfere with the growth of tumor cells. It is not yet known whether ipilimumab is more effective with or without high-dose recombinant interferon alfa-2b in treating melanoma.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patients must have unresectable stage III or stage IV melanoma, either initial presentation or recurrent, that is of cutaneous origin or unknown primary origin and that is histologically diagnosed.
- - No more than one prior systemic therapeutic regimen for unresectable stage III or stage IV melanoma; this includes chemotherapy, biologic therapy, biochemotherapy, or investigational treatment; this does not include any therapies given in the adjuvant setting; however, patients are excluded if they have a history of prior treatment for melanoma (either adjuvant or metastatic disease) with ipilimumab or other cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor, or prior interferon-alpha treatment for metastatic disease (history of adjuvant interferon-alpha is allowed); there should be a 4-week washout period between last treatment administration and initiation of study therapy.
- - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
- - Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of ipilimumab or HDI hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics.
- - Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed) - Patients who have other current malignancies are not eligible; patients with other malignancies are eligible if they have been continuously disease free for > 5 years prior to the time of randomization; one exception are patients treated with a curative intent and are continuously disease free for > 3 years; these patients would be considered eligible: - Patients with prior history at any time of any in situ cancer, lobular carcinoma of the breast in situ, cervical cancer in situ, atypical melanocytic hyperplasia or Clark I melanoma in situ are eligible.
- - Patients with prior history of basal or squamous skin cancer are eligible.
- - Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study; exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener's granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and Myasthenia gravis); other central nervous system (CNS) autoimmune disease (e.g., poliomyelitis, multiple sclerosis); patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible.
- - Due to the possible effect of treatment with ipilimumab on the immunologic response to infectious disease vaccines, patients must not have had any infectious disease vaccination (e.
- - Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study during screening to rule out pregnancy; NOTE: a woman of childbearing potential (WOCBP) is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); for the purposes of this study, post-menopause is defined as: - Amenorrhea >= 24 consecutive months without another cause, or.
- - For women with irregular menstrual periods and taking hormone replacement therapy (HRT), a documented serum follicle stimulating hormone (FSH) level >= 35 mIU/mL Women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential; men of fathering potential and WOCBP must be using an adequate method of contraception or must abstain from sexual intercourse to avoid conception/pregnancy throughout the study and for up to 26 weeks after the last dose of ipilimumab or HDI in such a manner that the risk of pregnancy is minimized; men or WOCBP who are unwilling or unable to strictly follow this requirement are not eligible.
- - White blood cells (WBC) >= 3000/uL.
- - Absolute neutrophil count (ANC) >= 1500/uL.
- - Platelets >= 100 x 10^3/uL.
- - Hemoglobin >= 10 g/dL.
- - Serum creatinine =< 1.8 mg/dl.
- - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) for patients with liver metastases and =< 2.0 x ULN for patients without liver metastases.
- - Serum bilirubin < 2 x ULN for patients with liver metastases and =< 1.5 x ULN for patients without liver metastases, (except patients with Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) - No active or chronic infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT01708941 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Ahmad Tarhini |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Recurrent Melanoma, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7 |
PRIMARY OBJECTIVES:
- I. Test the hypothesis that the combination of ipilimumab and high-dose interferon-alpha 2b (HDI [recombinant interferon alfa-2b]) will improve progression free survival (PFS) of patients with advanced metastatic melanoma as compared to ipilimumab alone (across ipilimumab treatment status).
- I. Test the hypothesis that the combination of ipilimumab and HDI will prove to be safe and tolerable.
- II. Within the constraints of the sample size, attempt to test the hypotheses that (1) ipilimumab 10 mg/kg will lead to improved PFS in comparison to ipilimumab 3 mg/kg (across HDI treatment status); (2) the combination of ipilimumab and HDI will improve overall survival (OS) of patients with advanced metastatic melanoma as compared to ipilimumab alone (across ipilimumab treatment status) and (3) ipilimumab 10 mg/kg will lead to improved OS in comparison to ipilimumab 3 mg/kg (across HDI treatment status).
Arms
Experimental: Arm A (higher dose ipilimumab, HDI)
INDUCTION PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses and recombinant interferon alfa-2b IV over 20 minutes 5 days a week for 4 weeks and then SC 3 times weekly for 8 weeks. MAINTENANCE PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24 and recombinant interferon alfa-2b SC 3 times weekly for 48 weeks.
Experimental: Arm B (higher dose ipilimumab)
INDUCTION PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses. MAINTENANCE PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24.
Experimental: Arm C (lower dose ipilimumab + HDI)
INDUCTION PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses and recombinant interferon alfa-2b IV over 20 minutes 5 days a week for 4 weeks and then SC 3 times weekly for 8 weeks. MAINTENANCE PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24 and recombinant interferon alfa-2b SC 3 times weekly for 48 weeks.
Experimental: Arm D (lower dose ipilimumab)
INDUCTION PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses. MAINTENANCE PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24.
Interventions
Biological: - Ipilimumab
Given IV
Other: - Laboratory Biomarker Analysis
Correlative studies
Biological: - Recombinant Interferon Alfa-2b
Given IV or SC
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764, 35233
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Address
Rocky Mountain Cancer Centers-Aurora
Aurora 5412347, Colorado 5417618, 80012
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The Medical Center of Aurora
Aurora 5412347, Colorado 5417618, 80012
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Address
Boulder Community Foothills Hospital
Boulder 5574991, Colorado 5417618, 80303
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Address
Rocky Mountain Cancer Centers-Boulder
Boulder 5574991, Colorado 5417618, 80304
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Address
Penrose-Saint Francis Healthcare
Colorado Springs 5417598, Colorado 5417618, 80907
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Address
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618, 80907
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Address
AdventHealth Porter
Denver 5419384, Colorado 5417618, 80210
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Address
Colorado Blood Cancer Institute
Denver 5419384, Colorado 5417618, 80218
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Address
Presbyterian - Saint Lukes Medical Center - Health One
Denver 5419384, Colorado 5417618, 80218
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Address
Saint Joseph Hospital - Cancer Centers of Colorado
Denver 5419384, Colorado 5417618, 80218
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Address
Rose Medical Center
Denver 5419384, Colorado 5417618, 80220
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Address
Western States Cancer Research NCORP
Denver 5419384, Colorado 5417618, 80222
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Address
Mountain Blue Cancer Care Center - Swedish
Englewood 5421250, Colorado 5417618, 80113
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Address
Swedish Medical Center
Englewood 5421250, Colorado 5417618, 80113
Status
Address
Banner North Colorado Medical Center
Greeley 5577592, Colorado 5417618, 80631
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Address
Saint Anthony Hospital
Lakewood 5427946, Colorado 5417618, 80228
Status
Address
Rocky Mountain Cancer Centers-Littleton
Littleton 5429032, Colorado 5417618, 80120
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Address
AdventHealth Littleton
Littleton 5429032, Colorado 5417618, 80122
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Address
Sky Ridge Medical Center
Lone Tree 5429208, Colorado 5417618, 80124
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Address
Longmont United Hospital
Longmont 5579276, Colorado 5417618, 80501
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Address
Banner McKee Medical Center
Loveland 5579368, Colorado 5417618, 80539
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Address
AdventHealth Parker
Parker 5434006, Colorado 5417618, 80138
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Address
Rocky Mountain Cancer Centers-Parker
Parker 5434006, Colorado 5417618, 80138
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Address
Saint Mary Corwin Medical Center
Pueblo 5435464, Colorado 5417618, 81004
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Address
Intermountain Health Lutheran Hospital
Wheat Ridge 5443948, Colorado 5417618, 80401
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Address
Smilow Cancer Hospital Care Center at Saint Francis
Hartford 4835797, Connecticut 4831725, 06105
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Address
Beebe Medical Center
Lewes 4143354, Delaware 4142224, 19958
Status
Address
Delaware Clinical and Laboratory Physicians PA
Newark 4143861, Delaware 4142224, 19713
Status
Address
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224, 19713
Status
Address
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224, 19713
Status
Address
Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224, 19718
Status
Address
Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224, 19971
Status
Address
TidalHealth Nanticoke / Allen Cancer Center
Seaford 4144600, Delaware 4142224, 19973
Status
Address
Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224, 19801
Status
Address
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000, 31405
Status
Address
Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512, 83706
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Address
Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861, 60504
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Address
OSF Saint Joseph Medical Center
Bloomington 4885164, Illinois 4896861, 61701
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Address
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861, 61704
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Address
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861, 61520
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Address
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861, 62321
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Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861, 62801
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Address
Northwestern University
Chicago 4887398, Illinois 4896861, 60611
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Address
Carle at The Riverfront
Danville 4889426, Illinois 4896861, 61832
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Address
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861, 62526
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Address
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861, 62526
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Address
Heartland Cancer Research NCORP
Decatur 4236895, Illinois 4896861, 62526
Status
Address
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861, 62401
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Address
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861, 62401
Status
Address
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861, 61530
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Address
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861, 61401
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Address
Western Illinois Cancer Treatment Center
Galesburg 4893392, Illinois 4896861, 61401
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Address
Ingalls Memorial Hospital
Harvey 4895298, Illinois 4896861, 60426
Status
Address
Hematology Oncology Associates of Illinois-Highland Park
Highland Park 4895876, Illinois 4896861, 60035
Status
Address
AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861, 60048
Status
Address
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861, 61455
Status
Address
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861, 61938
Status
Address
Garneau, Stewart C MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
Status
Address
Porubcin, Michael MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
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Address
Spector, David MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
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Address
Trinity Medical Center
Moline 4902476, Illinois 4896861, 61265
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Address
Illinois CancerCare-Monmouth
Monmouth 4902512, Illinois 4896861, 61462
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Address
Illinois Cancer Specialists-Niles
Niles 4903730, Illinois 4896861, 60714
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Address
Carle Cancer Institute Normal
Normal 4903780, Illinois 4896861, 61761
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Address
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861, 62269
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Address
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861, 61350
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Address
Ottawa Regional Hospital and Healthcare Center
Ottawa 4905006, Illinois 4896861, 61350
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Address
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861, 61554
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Address
OSF Saint Francis Radiation Oncology at Pekin
Pekin 4905599, Illinois 4896861, 61554
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Address
Proctor Hospital
Peoria 4905687, Illinois 4896861, 61614
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Address
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861, 61615
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Address
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria 4905687, Illinois 4896861, 61615
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Address
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861, 61636
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Address
OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861, 61637
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Address
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861, 61354
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Address
Valley Radiation Oncology
Peru 4905770, Illinois 4896861, 61354
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Address
Swedish American Hospital
Rockford 4907959, Illinois 4896861, 61104
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Address
UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861, 61114
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Address
Hematology Oncology Associates of Illinois - Skokie
Skokie 4911600, Illinois 4896861, 60076
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Address
Central Illinois Hematology Oncology Center
Springfield 4250542, Illinois 4896861, 62702
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Address
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861, 62702
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Address
Springfield Clinic
Springfield 4250542, Illinois 4896861, 62702
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Address
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861, 62781
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Address
Carle Cancer Center
Urbana 4914570, Illinois 4896861, 61801
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Address
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861, 61801
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Address
Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861, 60560
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Address
IU Health Central Indiana Cancer Centers-East
Indianapolis 4259418, Indiana 4921868, 46219
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Address
Franciscan Saint Anthony Health-Michigan City
Michigan City 4923531, Indiana 4921868, 46360
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Address
Woodland Cancer Care Center
Michigan City 4923531, Indiana 4921868, 46360
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Address
Mary Greeley Medical Center
Ames 4846834, Iowa 4862182, 50010
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Address
McFarland Clinic - Ames
Ames 4846834, Iowa 4862182, 50010
Status
Address
Constantinou, Costas L MD (UIA Investigator)
Bettendorf 4848489, Iowa 4862182, 52722
Status
Address
McFarland Clinic - Boone
Boone 4849051, Iowa 4862182, 50036
Status
Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182, 50325
Status
Address
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
Iowa-Wide Oncology Research Coalition NCORP
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182, 50309
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Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182, 50314
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Address
Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182, 50316
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Address
McFarland Clinic - Trinity Cancer Center
Fort Dodge 4857486, Iowa 4862182, 50501
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Address
McFarland Clinic - Jefferson
Jefferson 4862482, Iowa 4862182, 50129
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Address
McFarland Clinic - Marshalltown
Marshalltown 4866371, Iowa 4862182, 50158
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Address
Siouxland Regional Cancer Center
Sioux City 4876523, Iowa 4862182, 51101
Status
Address
Mercy Medical Center-Sioux City
Sioux City 4876523, Iowa 4862182, 51102
Status
Address
Saint Luke's Regional Medical Center
Sioux City 4876523, Iowa 4862182, 51104
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Address
Methodist West Hospital
West Des Moines 4881346, Iowa 4862182, 50266-7700
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Address
Cancer Center of Kansas - Chanute
Chanute 4269392, Kansas 4273857, 66720
Status
Address
Cancer Center of Kansas - Dodge City
Dodge City 5445298, Kansas 4273857, 67801
Status
Address
Cancer Center of Kansas - El Dorado
El Dorado 4270863, Kansas 4273857, 67042
Status
Address
Cancer Center of Kansas - Fort Scott
Fort Scott 4271690, Kansas 4273857, 66701
Status
Address
Cancer Center of Kansas-Independence
Independence 4273359, Kansas 4273857, 67301
Status
Address
Cancer Center of Kansas-Kingman
Kingman 4273978, Kansas 4273857, 67068
Status
Address
Lawrence Memorial Hospital
Lawrence 4274277, Kansas 4273857, 66044
Status
Address
Cancer Center of Kansas-Liberal
Liberal 5445820, Kansas 4273857, 67905
Status
Address
Cancer Center of Kansas-Manhattan
Manhattan 4274994, Kansas 4273857, 66502
Status
Address
Cancer Center of Kansas - McPherson
McPherson 4275261, Kansas 4273857, 67460
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Address
Cancer Center of Kansas - Newton
Newton 4276248, Kansas 4273857, 67114
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Address
Cancer Center of Kansas - Parsons
Parsons 4277011, Kansas 4273857, 67357
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Address
Cancer Center of Kansas - Pratt
Pratt 4277752, Kansas 4273857, 67124
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Address
Cancer Center of Kansas - Salina
Salina 4278890, Kansas 4273857, 67401
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Address
Cancer Center of Kansas - Wellington
Wellington 4281386, Kansas 4273857, 67152
Status
Address
Associates In Womens Health
Wichita 4281730, Kansas 4273857, 67208
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita 4281730, Kansas 4273857, 67208
Status
Address
Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Cancer Center of Kansas - Wichita
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Wichita NCI Community Oncology Research Program
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Cancer Center of Kansas - Winfield
Winfield 4281897, Kansas 4273857, 67156
Status
Address
Ochsner Health Center-Summa
Baton Rouge 4315588, Louisiana 4331987, 70809
Status
Address
Ochsner Baptist Medical Center
New Orleans 4335045, Louisiana 4331987, 70115
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Address
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987, 70121
Status
Address
Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885, 21204
Status
Address
Christiana Care - Union Hospital
Elkton 4354234, Maryland 4361885, 21921
Status
Address
Bixby Medical Center
Adrian 4983811, Michigan 5001836, 49221
Status
Address
Hickman Cancer Center
Adrian 4983811, Michigan 5001836, 49221
Status
Address
Michigan Cancer Research Consortium NCORP
Ann Arbor 4984247, Michigan 5001836, 48106
Status
Address
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836, 48106
Status
Address
Corewell Health Dearborn Hospital
Dearborn 4990510, Michigan 5001836, 48124
Status
Address
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836, 48236
Status
Address
OSF Saint Francis Hospital and Medical Group
Escanaba 4992232, Michigan 5001836, 49829
Status
Address
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836, 48503
Status
Address
Hurley Medical Center
Flint 4992982, Michigan 5001836, 48503
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Address
Allegiance Health
Jackson 4997384, Michigan 5001836, 49201
Status
Address
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836, 48912
Status
Address
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836, 48154
Status
Address
Mercy Memorial Hospital
Monroe 5002344, Michigan 5001836, 48162
Status
Address
Toledo Clinic Cancer Centers-Monroe
Monroe 5002344, Michigan 5001836, 48162
Status
Address
Lake Huron Medical Center
Port Huron 5006233, Michigan 5001836, 48060
Status
Address
MyMichigan Medical Center Saginaw
Saginaw 5007989, Michigan 5001836, 48601
Status
Address
Fairview Ridges Hospital
Burnsville 5019767, Minnesota 5037779, 55337
Status
Address
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779, 55433
Status
Address
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779, 55435
Status
Address
Unity Hospital
Fridley 5027482, Minnesota 5037779, 55432
Status
Address
Hutchinson Area Health Care
Hutchinson 5030977, Minnesota 5037779, 55350
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779, 55407
Status
Address
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779, 55415
Status
Address
Health Partners Inc
Minneapolis 5037649, Minnesota 5037779, 55454
Status
Address
New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779, 56073
Status
Address
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779, 55422
Status
Address
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Regions Hospital
Saint Paul 5045360, Minnesota 5037779, 55101
Status
Address
United Hospital
Saint Paul 5045360, Minnesota 5037779, 55102
Status
Address
Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779, 55379
Status
Address
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779, 55082
Status
Address
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779, 55387
Status
Address
Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779, 55125
Status
Address
Parkland Health Center-Bonne Terre
Bonne Terre 4377913, Missouri 4398678, 63628
Status
Address
Mercy Cancer Center - Cape Girardeau
Cape Girardeau 4379966, Missouri 4398678, 63703
Status
Address
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678, 63703
Status
Address
MU Health Care Goldschmidt Cancer Center
Jefferson City 4392388, Missouri 4398678, 65109
Status
Address
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678, 63670
Status
Address
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678, 63131
Status
Address
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678, 63080
Status
Address
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678, 63127
Status
Address
Nebraska Hematology and Oncology
Lincoln 5072006, Nebraska 5073708, 68506
Status
Address
Nebraska Cancer Research Center
Lincoln 5072006, Nebraska 5073708, 68510
Status
Address
Cancer Partners of Nebraska
Lincoln 5072006, Nebraska 5073708, 68516
Status
Address
Missouri Valley Cancer Consortium
Omaha 5074472, Nebraska 5073708, 68106
Status
Address
Alegent Health Immanuel Medical Center
Omaha 5074472, Nebraska 5073708, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708, 68124
Status
Address
Nebraska Cancer Specialists - Omaha
Omaha 5074472, Nebraska 5073708, 68124
Status
Address
Alegent Health Lakeside Hospital
Omaha 5074472, Nebraska 5073708, 68130
Status
Address
Oncology Hematology West PC
Omaha 5074472, Nebraska 5073708, 68130
Status
Address
Creighton University Medical Center
Omaha 5074472, Nebraska 5073708, 68131
Status
Address
Regional West Medical Center Cancer Center
Scottsbluff 5699404, Nebraska 5073708, 69361
Status
Address
Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760, 08103
Status
Address
Veterans Adminstration New Jersey Health Care System
East Orange 5097441, New Jersey 5101760, 07018-1095
Status
Address
Hunterdon Medical Center
Flemington 5098124, New Jersey 5101760, 08822
Status
Address
Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760, 08903
Status
Address
New York Oncology Hematology PC - Albany Medical Center
Albany 5106834, New York 5128638, 12208
Status
Address
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638, 11794
Status
Address
Summa Health System - Akron Campus
Akron 5145476, Ohio 5165418, 44304
Status
Address
Strecker Cancer Center-Belpre
Belpre 4506187, Ohio 5165418, 45714
Status
Address
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green 5147968, Ohio 5165418, 43402
Status
Address
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418, 45601
Status
Address
MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418, 44109
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418, 43214
Status
Address
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418, 43214
Status
Address
Columbus NCI Community Oncology Research Program
Columbus 4509177, Ohio 5165418, 43215
Status
Address
Grant Medical Center
Columbus 4509177, Ohio 5165418, 43215
Status
Address
The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418, 43219
Status
Address
Mount Carmel Health Center West
Columbus 4509177, Ohio 5165418, 43222
Status
Address
Doctors Hospital
Columbus 4509177, Ohio 5165418, 43228
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Delaware Radiation Oncology
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Fairfield Medical Center
Lancaster 4516233, Ohio 5165418, 43130
Status
Address
Lancaster Radiation Oncology
Lancaster 4516233, Ohio 5165418, 43130
Status
Address
Lima Memorial Hospital
Lima 5160783, Ohio 5165418, 45804
Status
Address
Marietta Memorial Hospital
Marietta 4517586, Ohio 5165418, 45750
Status
Address
Toledo Clinic Cancer Centers-Maumee
Maumee 5162137, Ohio 5165418, 43537
Status
Address
Knox Community Hospital
Mount Vernon 5163799, Ohio 5165418, 43050
Status
Address
Licking Memorial Hospital
Newark 5164466, Ohio 5165418, 43055
Status
Address
Newark Radiation Oncology
Newark 5164466, Ohio 5165418, 43055
Status
Address
Saint Charles Hospital
Oregon 5165734, Ohio 5165418, 43616
Status
Address
Toledo Clinic Cancer Centers-Oregon
Oregon 5165734, Ohio 5165418, 43616
Status
Address
Southern Ohio Medical Center
Portsmouth 4521816, Ohio 5165418, 45662
Status
Address
Springfield Regional Medical Center
Springfield 4525353, Ohio 5165418, 45504
Status
Address
ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418, 43560
Status
Address
Mercy Hospital of Tiffin
Tiffin 5173930, Ohio 5165418, 44883
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
Status
Address
Mercy Health - Saint Vincent Hospital
Toledo 5174035, Ohio 5165418, 43608
Status
Address
University of Toledo
Toledo 5174035, Ohio 5165418, 43614
Status
Address
Toledo Community Hospital Oncology Program CCOP
Toledo 5174035, Ohio 5165418, 43617
Status
Address
Mercy Health - Saint Anne Hospital
Toledo 5174035, Ohio 5165418, 43623
Status
Address
Toledo Clinic Cancer Centers-Toledo
Toledo 5174035, Ohio 5165418, 43623
Status
Address
Fulton County Health Center
Wauseon 5175877, Ohio 5165418, 43567
Status
Address
Saint Ann's Hospital
Westerville 5176472, Ohio 5165418, 43081
Status
Address
Genesis Healthcare System Cancer Care Center
Zanesville 4528923, Ohio 5165418, 43701
Status
Address
Natalie Warren Bryant Cancer Center at Saint Francis
Tulsa 4553433, Oklahoma 4544379, 74136
Status
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
Status
Address
Geisinger Medical Center-Cancer Center Hazleton
Hazleton 5193011, Pennsylvania 6254927, 18201
Status
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927, 17837
Status
Address
Lewistown Hospital
Lewistown 5197850, Pennsylvania 6254927, 17044
Status
Address
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927, 19111
Status
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927, 15232
Status
Address
Geisinger Cancer Services-Pottsville
Pottsville 5207080, Pennsylvania 6254927, 17901
Status
Address
Geisinger Medical Group
State College 5213681, Pennsylvania 6254927, 16801
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927, 18711
Status
Address
Erlanger Medical Center
Chattanooga 4612862, Tennessee 4662168, 37403
Status
Address
Fredericksburg Oncology Inc
Fredericksburg 4760059, Virginia 6254928, 22401
Status
Address
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850, 25304
Status
Address
Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468, 53105
Status
Address
Aurora Health Center-Fond du Lac
Fond du Lac 5253352, Wisconsin 5279468, 54937
Status
Address
Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468, 53022
Status
Address
Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468, 53024
Status
Address
Green Bay Oncology at Saint Vincent Hospital
Green Bay 5254962, Wisconsin 5279468, 54301-3526
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468, 54301
Status
Address
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468, 54303
Status
Address
Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468, 54311
Status
Address
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468, 53038
Status
Address
Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468, 53142
Status
Address
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468, 54601
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468, 53792
Status
Address
Holy Family Memorial Hospital
Manitowoc 5261585, Wisconsin 5279468, 54221
Status
Address
Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468, 54143
Status
Address
Bay Area Medical Center
Marinette 5261852, Wisconsin 5279468, 54143
Status
Address
Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468, 53209
Status
Address
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee 5263045, Wisconsin 5279468, 53210
Status
Address
Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468, 53215
Status
Address
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
Status
Address
Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468, 53233
Status
Address
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468, 54017
Status
Address
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468, 54154
Status
Address
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468, 54904
Status
Address
Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468, 53406
Status
Address
HSHS Saint Nicholas Hospital
Sheboygan 5272893, Wisconsin 5279468, 53081
Status
Address
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468, 53081
Status
Address
Aurora Medical Center in Summit
Summit, Wisconsin 5279468, 53066
Status
Address
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468, 54241
Status
Address
Aurora Cancer Care-Waukesha
Waukesha 5278052, Wisconsin 5279468, 53188
Status
Address
Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468, 53226
Status
Address
Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468, 53227
