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Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
Study Purpose
This randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, may block tumor growth by targeting certain cells. Recombinant interferon alfa-2b may interfere with the growth of tumor cells. It is not yet known whether ipilimumab is more effective with or without high-dose recombinant interferon alfa-2b in treating melanoma.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patients must have unresectable stage III or stage IV melanoma, either initial presentation or recurrent, that is of cutaneous origin or unknown primary origin and that is histologically diagnosed.
- - No more than one prior systemic therapeutic regimen for unresectable stage III or stage IV melanoma; this includes chemotherapy, biologic therapy, biochemotherapy, or investigational treatment; this does not include any therapies given in the adjuvant setting; however, patients are excluded if they have a history of prior treatment for melanoma (either adjuvant or metastatic disease) with ipilimumab or other cytotoxic T-lymphocyte antigen 4 (CTLA-4) inhibitor, or prior interferon-alpha treatment for metastatic disease (history of adjuvant interferon-alpha is allowed); there should be a 4-week washout period between last treatment administration and initiation of study therapy.
- - Patients must have Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
- - Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of ipilimumab or HDI hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics.
- - Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed) - Patients who have other current malignancies are not eligible; patients with other malignancies are eligible if they have been continuously disease free for > 5 years prior to the time of randomization; one exception are patients treated with a curative intent and are continuously disease free for > 3 years; these patients would be considered eligible: - Patients with prior history at any time of any in situ cancer, lobular carcinoma of the breast in situ, cervical cancer in situ, atypical melanocytic hyperplasia or Clark I melanoma in situ are eligible.
- - Patients with prior history of basal or squamous skin cancer are eligible.
- - Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study; exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener's granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and Myasthenia gravis); other central nervous system (CNS) autoimmune disease (e.g., poliomyelitis, multiple sclerosis); patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible.
- - Due to the possible effect of treatment with ipilimumab on the immunologic response to infectious disease vaccines, patients must not have had any infectious disease vaccination (e.
- - Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study during screening to rule out pregnancy; NOTE: a woman of childbearing potential (WOCBP) is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); for the purposes of this study, post-menopause is defined as: - Amenorrhea >= 24 consecutive months without another cause, or.
- - For women with irregular menstrual periods and taking hormone replacement therapy (HRT), a documented serum follicle stimulating hormone (FSH) level >= 35 mIU/mL Women who are using oral contraceptives, other hormonal contraceptives (vaginal products, skin patches, or implanted or injectable products), or mechanical products such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to prevent pregnancy, or are practicing abstinence or where their partner is sterile (e.g., vasectomy) should be considered to be of childbearing potential; men of fathering potential and WOCBP must be using an adequate method of contraception or must abstain from sexual intercourse to avoid conception/pregnancy throughout the study and for up to 26 weeks after the last dose of ipilimumab or HDI in such a manner that the risk of pregnancy is minimized; men or WOCBP who are unwilling or unable to strictly follow this requirement are not eligible.
- - White blood cells (WBC) >= 3000/uL.
- - Absolute neutrophil count (ANC) >= 1500/uL.
- - Platelets >= 100 x 10^3/uL.
- - Hemoglobin >= 10 g/dL.
- - Serum creatinine =< 1.8 mg/dl.
- - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) for patients with liver metastases and =< 2.0 x ULN for patients without liver metastases.
- - Serum bilirubin < 2 x ULN for patients with liver metastases and =< 1.5 x ULN for patients without liver metastases, (except patients with Gilbert's syndrome, who must have a total bilirubin < 3.0 mg/dL) - No active or chronic infection with human immunodeficiency virus (HIV), hepatitis B, or hepatitis C.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT01708941 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Ahmad Tarhini |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Recurrent Melanoma, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7, Stage IV Cutaneous Melanoma AJCC v6 and v7 |
PRIMARY OBJECTIVES:
- I. Test the hypothesis that the combination of ipilimumab and high-dose interferon-alpha 2b (HDI [recombinant interferon alfa-2b]) will improve progression free survival (PFS) of patients with advanced metastatic melanoma as compared to ipilimumab alone (across ipilimumab treatment status).
- I. Test the hypothesis that the combination of ipilimumab and HDI will prove to be safe and tolerable.
- II. Within the constraints of the sample size, attempt to test the hypotheses that (1) ipilimumab 10 mg/kg will lead to improved PFS in comparison to ipilimumab 3 mg/kg (across HDI treatment status); (2) the combination of ipilimumab and HDI will improve overall survival (OS) of patients with advanced metastatic melanoma as compared to ipilimumab alone (across ipilimumab treatment status) and (3) ipilimumab 10 mg/kg will lead to improved OS in comparison to ipilimumab 3 mg/kg (across HDI treatment status).
Arms
Experimental: Arm A (higher dose ipilimumab, HDI)
INDUCTION PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses and recombinant interferon alfa-2b IV over 20 minutes 5 days a week for 4 weeks and then SC 3 times weekly for 8 weeks. MAINTENANCE PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24 and recombinant interferon alfa-2b SC 3 times weekly for 48 weeks.
Experimental: Arm B (higher dose ipilimumab)
INDUCTION PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses. MAINTENANCE PHASE: Patients receive higher dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24.
Experimental: Arm C (lower dose ipilimumab + HDI)
INDUCTION PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses and recombinant interferon alfa-2b IV over 20 minutes 5 days a week for 4 weeks and then SC 3 times weekly for 8 weeks. MAINTENANCE PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24 and recombinant interferon alfa-2b SC 3 times weekly for 48 weeks.
Experimental: Arm D (lower dose ipilimumab)
INDUCTION PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 3 weeks for 4 doses. MAINTENANCE PHASE: Patients receive lower dose ipilimumab IV over 90 minutes once every 12 weeks for 4 doses beginning in week 24.
Interventions
Biological: - Ipilimumab
Given IV
Other: - Laboratory Biomarker Analysis
Correlative studies
Biological: - Recombinant Interferon Alfa-2b
Given IV or SC
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
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Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado, 80012
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The Medical Center of Aurora
Aurora, Colorado, 80012
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Boulder Community Foothills Hospital
Boulder, Colorado, 80303
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Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado, 80304
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Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
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Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
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AdventHealth Porter
Denver, Colorado, 80210
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Colorado Blood Cancer Institute
Denver, Colorado, 80218
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Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218
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Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado, 80218
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Rose Medical Center
Denver, Colorado, 80220
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Western States Cancer Research NCORP
Denver, Colorado, 80222
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Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado, 80113
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Swedish Medical Center
Englewood, Colorado, 80113
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Banner North Colorado Medical Center
Greeley, Colorado, 80631
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Saint Anthony Hospital
Lakewood, Colorado, 80228
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Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado, 80120
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AdventHealth Littleton
Littleton, Colorado, 80122
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Sky Ridge Medical Center
Lone Tree, Colorado, 80124
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Longmont United Hospital
Longmont, Colorado, 80501
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Banner McKee Medical Center
Loveland, Colorado, 80539
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AdventHealth Parker
Parker, Colorado, 80138
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Rocky Mountain Cancer Centers-Parker
Parker, Colorado, 80138
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Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
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Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado, 80401
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Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut, 06105
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Beebe Medical Center
Lewes, Delaware, 19958
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Address
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
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Helen F Graham Cancer Center
Newark, Delaware, 19713
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Address
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
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Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
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Beebe Health Campus
Rehoboth Beach, Delaware, 19971
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TidalHealth Nanticoke / Allen Cancer Center
Seaford, Delaware, 19973
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Address
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
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Address
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
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Address
Rush-Copley Medical Center
Aurora, Illinois, 60504
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OSF Saint Joseph Medical Center
Bloomington, Illinois, 61701
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Address
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
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Address
Illinois CancerCare-Canton
Canton, Illinois, 61520
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Address
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
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Address
Centralia Oncology Clinic
Centralia, Illinois, 62801
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Address
Northwestern University
Chicago, Illinois, 60611
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Carle at The Riverfront
Danville, Illinois, 61832
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Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
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Decatur Memorial Hospital
Decatur, Illinois, 62526
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Address
Heartland Cancer Research NCORP
Decatur, Illinois, 62526
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Carle Physician Group-Effingham
Effingham, Illinois, 62401
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Crossroads Cancer Center
Effingham, Illinois, 62401
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Illinois CancerCare-Eureka
Eureka, Illinois, 61530
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Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
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Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
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Ingalls Memorial Hospital
Harvey, Illinois, 60426
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Address
Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, 60035
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AMG Libertyville - Oncology
Libertyville, Illinois, 60048
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Illinois CancerCare-Macomb
Macomb, Illinois, 61455
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Address
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
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Address
Garneau, Stewart C MD (UIA Investigator)
Moline, Illinois, 61265
Status
Address
Porubcin, Michael MD (UIA Investigator)
Moline, Illinois, 61265
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Address
Spector, David MD (UIA Investigator)
Moline, Illinois, 61265
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Address
Trinity Medical Center
Moline, Illinois, 61265
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Address
Illinois CancerCare-Monmouth
Monmouth, Illinois, 61462
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Address
Illinois Cancer Specialists-Niles
Niles, Illinois, 60714
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Address
Carle Cancer Institute Normal
Normal, Illinois, 61761
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Address
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
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Address
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
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Address
Ottawa Regional Hospital and Healthcare Center
Ottawa, Illinois, 61350
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Address
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
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Address
OSF Saint Francis Radiation Oncology at Pekin
Pekin, Illinois, 61554
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Address
Proctor Hospital
Peoria, Illinois, 61614
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Address
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
Status
Address
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois, 61615
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Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
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Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
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Address
Illinois CancerCare-Peru
Peru, Illinois, 61354
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Address
Valley Radiation Oncology
Peru, Illinois, 61354
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Address
Swedish American Hospital
Rockford, Illinois, 61104
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Address
UW Health Carbone Cancer Center Rockford
Rockford, Illinois, 61114
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Address
Hematology Oncology Associates of Illinois - Skokie
Skokie, Illinois, 60076
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Address
Central Illinois Hematology Oncology Center
Springfield, Illinois, 62702
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Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
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Address
Springfield Clinic
Springfield, Illinois, 62702
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Address
Springfield Memorial Hospital
Springfield, Illinois, 62781
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Address
Carle Cancer Center
Urbana, Illinois, 61801
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Address
The Carle Foundation Hospital
Urbana, Illinois, 61801
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Address
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
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Address
IU Health Central Indiana Cancer Centers-East
Indianapolis, Indiana, 46219
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Address
Franciscan Saint Anthony Health-Michigan City
Michigan City, Indiana, 46360
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Address
Woodland Cancer Care Center
Michigan City, Indiana, 46360
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Address
Mary Greeley Medical Center
Ames, Iowa, 50010
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Address
McFarland Clinic - Ames
Ames, Iowa, 50010
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Address
Constantinou, Costas L MD (UIA Investigator)
Bettendorf, Iowa, 52722
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Address
McFarland Clinic - Boone
Boone, Iowa, 50036
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Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
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Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
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Address
Iowa-Wide Oncology Research Coalition NCORP
Des Moines, Iowa, 50309
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Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
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Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
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Address
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
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Address
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
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McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
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McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
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Address
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101
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Mercy Medical Center-Sioux City
Sioux City, Iowa, 51102
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Saint Luke's Regional Medical Center
Sioux City, Iowa, 51104
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Address
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
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Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720
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Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
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Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042
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Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701
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Cancer Center of Kansas-Independence
Independence, Kansas, 67301
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Address
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068
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Lawrence Memorial Hospital
Lawrence, Kansas, 66044
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Cancer Center of Kansas-Liberal
Liberal, Kansas, 67905
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Cancer Center of Kansas-Manhattan
Manhattan, Kansas, 66502
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Cancer Center of Kansas - McPherson
McPherson, Kansas, 67460
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Address
Cancer Center of Kansas - Newton
Newton, Kansas, 67114
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Address
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357
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Address
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124
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Address
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
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Address
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
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Address
Associates In Womens Health
Wichita, Kansas, 67208
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Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
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Address
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
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Address
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
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Address
Wichita NCI Community Oncology Research Program
Wichita, Kansas, 67214
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Address
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
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Address
Ochsner Health Center-Summa
Baton Rouge, Louisiana, 70809
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Address
Ochsner Baptist Medical Center
New Orleans, Louisiana, 70115
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Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
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Address
Greater Baltimore Medical Center
Baltimore, Maryland, 21204
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Address
Christiana Care - Union Hospital
Elkton, Maryland, 21921
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Address
Bixby Medical Center
Adrian, Michigan, 49221
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Address
Hickman Cancer Center
Adrian, Michigan, 49221
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Address
Michigan Cancer Research Consortium NCORP
Ann Arbor, Michigan, 48106
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Address
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, 48106
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Address
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
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Address
Henry Ford Health Saint John Hospital
Detroit, Michigan, 48236
Status
Address
OSF Saint Francis Hospital and Medical Group
Escanaba, Michigan, 49829
Status
Address
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
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Address
Hurley Medical Center
Flint, Michigan, 48503
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Address
Allegiance Health
Jackson, Michigan, 49201
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Address
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, 48912
Status
Address
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
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Address
Mercy Memorial Hospital
Monroe, Michigan, 48162
Status
Address
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan, 48162
Status
Address
Lake Huron Medical Center
Port Huron, Michigan, 48060
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Address
MyMichigan Medical Center Saginaw
Saginaw, Michigan, 48601
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Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
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Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
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Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
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Address
Unity Hospital
Fridley, Minnesota, 55432
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Address
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
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Address
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
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Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
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Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
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Address
Health Partners Inc
Minneapolis, Minnesota, 55454
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Address
New Ulm Medical Center
New Ulm, Minnesota, 56073
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Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Status
Address
Metro Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota, 55416
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Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
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Address
Regions Hospital
Saint Paul, Minnesota, 55101
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Address
United Hospital
Saint Paul, Minnesota, 55102
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Address
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
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Address
Lakeview Hospital
Stillwater, Minnesota, 55082
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Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
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Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Address
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri, 63628
Status
Address
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
Status
Address
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Status
Address
MU Health Care Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
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Address
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
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Address
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Status
Address
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
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Address
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
Status
Address
Nebraska Hematology and Oncology
Lincoln, Nebraska, 68506
Status
Address
Nebraska Cancer Research Center
Lincoln, Nebraska, 68510
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Address
Cancer Partners of Nebraska
Lincoln, Nebraska, 68516
Status
Address
Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106
Status
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Nebraska Cancer Specialists - Omaha
Omaha, Nebraska, 68124
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Address
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Status
Address
Oncology Hematology West PC
Omaha, Nebraska, 68130
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131
Status
Address
Regional West Medical Center Cancer Center
Scottsbluff, Nebraska, 69361
Status
Address
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
Status
Address
Veterans Adminstration New Jersey Health Care System
East Orange, New Jersey, 07018-1095
Status
Address
Hunterdon Medical Center
Flemington, New Jersey, 08822
Status
Address
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
Status
Address
New York Oncology Hematology PC - Albany Medical Center
Albany, New York, 12208
Status
Address
Stony Brook University Medical Center
Stony Brook, New York, 11794
Status
Address
Summa Health System - Akron Campus
Akron, Ohio, 44304
Status
Address
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
Status
Address
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green, Ohio, 43402
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Status
Address
MetroHealth Medical Center
Cleveland, Ohio, 44109
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
Status
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Address
Columbus NCI Community Oncology Research Program
Columbus, Ohio, 43215
Status
Address
Grant Medical Center
Columbus, Ohio, 43215
Status
Address
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Status
Address
Mount Carmel Health Center West
Columbus, Ohio, 43222
Status
Address
Doctors Hospital
Columbus, Ohio, 43228
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
Status
Address
Delaware Radiation Oncology
Delaware, Ohio, 43015
Status
Address
Grady Memorial Hospital
Delaware, Ohio, 43015
Status
Address
Fairfield Medical Center
Lancaster, Ohio, 43130
Status
Address
Lancaster Radiation Oncology
Lancaster, Ohio, 43130
Status
Address
Lima Memorial Hospital
Lima, Ohio, 45804
Status
Address
Marietta Memorial Hospital
Marietta, Ohio, 45750
Status
Address
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
Status
Address
Knox Community Hospital
Mount Vernon, Ohio, 43050
Status
Address
Licking Memorial Hospital
Newark, Ohio, 43055
Status
Address
Newark Radiation Oncology
Newark, Ohio, 43055
Status
Address
Saint Charles Hospital
Oregon, Ohio, 43616
Status
Address
Toledo Clinic Cancer Centers-Oregon
Oregon, Ohio, 43616
Status
Address
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
Status
Address
Springfield Regional Medical Center
Springfield, Ohio, 45504
Status
Address
ProMedica Flower Hospital
Sylvania, Ohio, 43560
Status
Address
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
Status
Address
Mercy Health - Saint Vincent Hospital
Toledo, Ohio, 43608
Status
Address
University of Toledo
Toledo, Ohio, 43614
Status
Address
Toledo Community Hospital Oncology Program CCOP
Toledo, Ohio, 43617
Status
Address
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
Status
Address
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
Status
Address
Fulton County Health Center
Wauseon, Ohio, 43567
Status
Address
Saint Ann's Hospital
Westerville, Ohio, 43081
Status
Address
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
Status
Address
Natalie Warren Bryant Cancer Center at Saint Francis
Tulsa, Oklahoma, 74136
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Status
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Status
Address
Lewistown Hospital
Lewistown, Pennsylvania, 17044
Status
Address
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
Status
Address
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
Status
Address
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, 17901
Status
Address
Geisinger Medical Group
State College, Pennsylvania, 16801
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
Erlanger Medical Center
Chattanooga, Tennessee, 37403
Status
Address
Fredericksburg Oncology Inc
Fredericksburg, Virginia, 22401
Status
Address
West Virginia University Charleston Division
Charleston, West Virginia, 25304
Status
Address
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
Status
Address
Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin, 54937
Status
Address
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
Status
Address
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
Status
Address
Green Bay Oncology at Saint Vincent Hospital
Green Bay, Wisconsin, 54301-3526
Status
Address
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
Status
Address
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin, 54303
Status
Address
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
Status
Address
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin, 53038
Status
Address
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
Status
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Status
Address
Holy Family Memorial Hospital
Manitowoc, Wisconsin, 54221
Status
Address
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
Status
Address
Bay Area Medical Center
Marinette, Wisconsin, 54143
Status
Address
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
Status
Address
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee, Wisconsin, 53210
Status
Address
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
Status
Address
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Address
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
Status
Address
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
Status
Address
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin, 54154
Status
Address
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
Status
Address
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
Status
Address
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin, 53081
Status
Address
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
Status
Address
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
Status
Address
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
Status
Address
Aurora Cancer Care-Waukesha
Waukesha, Wisconsin, 53188
Status
Address
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
Status
Address
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
