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Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors
Study Purpose
This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with advanced pancreatic neuroendocrine tumors. Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patient must have histologically or pathologically confirmed locally unresectable or metastatic low or intermediate grade pancreatic neuroendocrine tumor.
- - Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained <= 4 weeks prior to randomization and must be acquired by multiphasic CT or contrast magnetic resonance imaging (MRI) - Date of last documented disease progression must be within 12 months from date of randomization.
- - Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued >= 4 weeks prior to randomization.
- - Concurrent somatostatin analogues are allowed provided that patients.
- - Have been on a stable dose for 8 weeks and.
- - Have documented disease progression on that dose.
- - Chemoembolization is allowed if ≥ 4 weeks from study entry.
- - If patient has hepatic disease only: they need to have progressed in the liver since chemoembolization and have measurable disease by RECIST 1.1 in order to be eligible.
- - If patient has hepatic and extrahepatic disease: they will need to have progressed inside OR outside the liver and have measureable disease by RECIST 1.1 in order to be eligible.
- - Leukocytes >= 3,000/mm^3.
- - Absolute neutrophil count >= 1,500/mm^3.
- - Hemoglobin >= 9 g/dL.
- - Platelets >= 100,000/mm^3.
- - Total bilirubin <= institutional upper limit of normal (ULN) or <= 1.5 X institutional ULN (if the patient has liver metastases) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) <= 3 X institutional ULN or (<= 5 X institutional ULN if the patient has liver metastases) - Serum creatinine <= 1.5 X institutional ULN.
- - Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- - Patient must have life expectancy >= 12 weeks all females of childbearing potential must have a blood test or urine study within =< 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: - Has not undergone a hysterectomy or bilateral oophorectomy; or.
- - Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) - Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately.
- - Patient must be able to swallow pills.
- - Patient must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for their treatment and the protocol.
Exclusion Criteria:
- - Small cell carcinoma.
- - Prior temozolomide, dacarbazine (DTIC), or capecitabine, or 5-FU (fluorouracil) therapy.
- - Receiving any other investigational agents while on study treatment.
- - Receiving Coumadin while on treatment; other anticoagulants are allowed.
- - Patients with either clinically apparent central nervous system metastases or carcinomatous meningitis are ineligible.
- - Active or uncontrolled infection or serious medical or psychiatric illness.
- - History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine.
- - Absorption issues that would limit the ability to absorb study agents.
- - Patients with a history of the following within 12 months of study entry: - Arterial thromboembolic events.
- - Unstable angina.
- - Myocardial Infarction.
- - Symptomatic peripheral vascular disease.
- - Patients with previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions: - Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ OR.
- - Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR.
- - Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT01824875 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
ECOG-ACRIN Cancer Research Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Pamela Kunz |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Gastrinoma, Glucagonoma, Insulinoma, Islet Cell Carcinoma, Pancreatic Polypeptide Tumor, Recurrent Islet Cell Carcinoma, Somatostatinoma |
PRIMARY OBJECTIVES:
- I. To evaluate progression-free survival (PFS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.
- I. To evaluate response rates (RR) associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.
- II. To evaluate overall survival (OS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.
- III. To evaluate the toxicity associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.
- IV. To evaluate the usefulness of methyl guanine methyltransferase (MGMT) status (by immunohistochemistry [IHC] and promoter methylation) for predicting response in pancreatic neuroendocrine tumor patients treated with either temozolomide or temozolomide and capecitabine.
- V. To bank radiology images for evaluation of quality, reproducibility, and compliance with computed tomography (CT) methodology.
Arms
Experimental: Arm A (temozolomide)
Patients receive temozolomide PO QD on days 1-5. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Experimental: Arm B (temozolomide and capecitabine)
Patients receive capecitabine PO BID on days 1-14 and temozolomide PO QD on days 10-14. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Interventions
Drug: - temozolomide
Given PO
Drug: - capecitabine
Given PO
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
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Kaiser Anaheim Medical Center
Anaheim, California, 92807
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Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
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Kaiser Permanente Medical Group - Baldwin Park
Baldwin Park, California, 91706
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Kaiser Foundation Hospital
Bellflower, California, 90706
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Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California, 94704
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Mills - Peninsula Hospitals
Burlingame, California, 94010
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Kaiser Permanente Hospital
Fontana, California, 92335
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Kaiser Permanente, Fremont
Fremont, California, 94538
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Kaiser Permanente
Fresno, California, 93720
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Kaiser Permanente - Harbor City
Harbor City, California, 90710
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Kaiser Permanente, Hayward
Hayward, California, 94545
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Southern California Permanente Medical Group
Irvine, California, 92618
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Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
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University of Southern California/Norris Cancer Center
Los Angeles, California, 90033
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Kaiser Permanente-West Los Angeles
Los Angeles, California, 90034
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Cedars-Sinai Medical Center
Los Angeles, California, 90048
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Kaiser Permanente-Modesto
Modesto, California, 95356
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Sutter Cancer Research Consortium
Novato, California, 94945
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Kaiser Permanente-Oakland
Oakland, California, 94611
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University of California Medical Center At Irvine-Orange Campus
Orange, California, 92868
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Kaiser Permanente - Panorama City
Panorama City, California, 91402
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Kaiser Permanente-Redwood City
Redwood City, California, 94063
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Kaiser Permanente-Richmond
Richmond, California, 94801
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Kaiser Permanente Medical Center
Riverside, California, 92505
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Kaiser Permanente-Roseville
Roseville, California, 95661
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Kaiser Permanente-South Sacramento
Sacramento, California, 95823
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Kaiser Permanente - Sacramento
Sacramento, California, 95825
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Kaiser Permanente at San Diego
San Diego, California, 92120
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Kaiser Permanente
San Diego, California, 92120
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Kaiser Permanente-San Francisco
San Francisco, California, 94115
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UCSF-Mount Zion
San Francisco, California, 94115
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California Pacific Medical Center
San Francisco, California, 94118
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Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
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Kaiser Permanente Health Care
San Marcos, California, 92069
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Kaiser Permanente-San Rafael
San Rafael, California, 94903
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Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
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Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
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Sutter Pacific Medical Foundation
Santa Rosa, California, 95403
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Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
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Stanford University Hospitals and Clinics
Stanford, California, 94305
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Kaiser Permanente-Stockton
Stockton, California, 95210
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Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
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Kaiser Permanente-Vallejo
Vallejo, California, 94589
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Sutter Solano Medical Center
Vallejo, California, 94589
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Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
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Kaiser Permanente
Woodland Hills, California, 91367
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Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105
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Middlesex Hospital
Middletown, Connecticut, 06457
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Beebe Medical Center
Lewes, Delaware, 19958
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Address
Christiana Gynecologic Oncology LLC
Newark, Delaware, 19713
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Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
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Helen F Graham Cancer Center
Newark, Delaware, 19713
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Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
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Regional Hematology and Oncology PA
Newark, Delaware, 19713
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Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
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Beebe Health Campus
Rehoboth Beach, Delaware, 19971
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Nanticoke Memorial Hospital
Seaford, Delaware, 19973
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Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
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Address
Edna Williams Cancer Center at the Baptist Cancer Institute
Jacksonville, Florida, 32207
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Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
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Address
Florida Hospital
Orlando, Florida, 32803
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H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, 33612
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Address
Oncare Hawaii Inc-Pali Momi
'Aiea, Hawaii, 96701
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Address
Pali Momi Medical Center
'Aiea, Hawaii, 96701
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Address
Oncare Hawaii Inc-POB II
Honolulu, Hawaii, 96813
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Queen's Medical Center
Honolulu, Hawaii, 96813
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Address
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
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Address
University of Hawaii
Honolulu, Hawaii, 96813
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Address
OnCare Hawaii-Liliha
Honolulu, Hawaii, 96817-3169
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Address
Oncare Hawaii Inc-Kuakini
Honolulu, Hawaii, 96817
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Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
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Address
Castle Medical Center
Kailua, Hawaii, 96734
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Address
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
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Address
Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706
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Address
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61701
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Saint Joseph Medical Center
Bloomington, Illinois, 61701
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Address
Illinois CancerCare-Canton
Canton, Illinois, 61520
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Address
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
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Illinois CancerCare-Carthage
Carthage, Illinois, 62321
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Centralia Oncology Clinic
Centralia, Illinois, 62801
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Northwestern University
Chicago, Illinois, 60611
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University of Illinois
Chicago, Illinois, 60612
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Cancer Care Center of Decatur
Decatur, Illinois, 62526
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Decatur Memorial Hospital
Decatur, Illinois, 62526
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Crossroads Cancer Center
Effingham, Illinois, 62401
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Illinois CancerCare-Eureka
Eureka, Illinois, 61530
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Illinois CancerCare Galesburg
Galesburg, Illinois, 61401
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Illinois CancerCare-Galesburg Cottage Plaza Office
Galesburg, Illinois, 61401
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Hematology Oncology Associates of Illinois-Highland Park
Highland Park, Illinois, 60035
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Address
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale, Illinois, 60521
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Address
Presence Saint Mary's Hospital
Kankakee, Illinois, 60901
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Address
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
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Address
North Shore Hematology Oncology
Libertyville, Illinois, 60048
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Address
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
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Address
Loyola University Medical Center
Maywood, Illinois, 60153
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Address
Garneau, Stewart C MD (UIA Investigator)
Moline, Illinois, 61265
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Address
Porubcin, Michael MD (UIA Investigator)
Moline, Illinois, 61265
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Address
Spector, David MD (UIA Investigator)
Moline, Illinois, 61265
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Address
Trinity Medical Center
Moline, Illinois, 61265
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Address
Illinois CancerCare-Monmouth
Monmouth, Illinois, 61462
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Address
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864
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Address
Illinois Cancer Specialists-Niles
Niles, Illinois, 60714
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Address
Community Cancer Center Foundation
Normal, Illinois, 61761
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Address
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
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Address
Ottawa Regional Hospital and Healthcare Center
Ottawa, Illinois, 61350
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Address
Pekin Cancer Treatment Center
Pekin, Illinois, 61554
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Address
Illinois CancerCare-Pekin
Pekin, Illinois, 61603
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Address
Methodist Medical Center of Illinois
Peoria, Illinois, 61603
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Proctor Hospital
Peoria, Illinois, 61614
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Address
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
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Address
Illinois Oncology Research Association CCOP
Peoria, Illinois, 61615
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Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
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Address
Illinois CancerCare-Peru
Peru, Illinois, 61354
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Address
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
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Address
SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois, 61107
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Address
Hematology Oncology Associates of Illinois - Skokie
Skokie, Illinois, 60076
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Address
Memorial Medical Center
Springfield, Illinois, 62781-0001
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Address
Franciscan Saint Francis Health-Indianapolis
Indianapolis, Indiana, 46237
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Address
Reid Hospital and Health Care Services
Richmond, Indiana, 47374
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Address
Mary Greeley Medical Center
Ames, Iowa, 50010
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Address
McFarland Clinic PC-William R Bliss Cancer Center
Ames, Iowa, 50010
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Address
Constantinou, Costas L MD (UIA Investigator)
Bettendorf, Iowa, 52722
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Address
McFarland Clinic PC-Boone
Boone, Iowa, 50036
Status
Address
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325
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Address
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
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Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
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Address
Iowa Oncology Research Association CCOP
Des Moines, Iowa, 50309
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Address
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309
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Address
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, 50314
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Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
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Address
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
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Address
McFarland Clinic PC-Jefferson
Jefferson, Iowa, 50129
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Address
McFarland Clinic PC-Marshalltown
Marshalltown, Iowa, 50158
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Address
Siouxland Hematology Oncology Associates
Sioux City, Iowa, 51101
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Address
Mercy Medical Center-Sioux City
Sioux City, Iowa, 51104
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Saint Luke's Regional Medical Center
Sioux City, Iowa, 51104
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Address
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
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Address
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
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Address
Cancer Center of Kansas - Chanute
Chanute, Kansas, 66720
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Cancer Center of Kansas - Dodge City
Dodge City, Kansas, 67801
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Cancer Center of Kansas - El Dorado
El Dorado, Kansas, 67042
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Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701
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Cancer Center of Kansas-Independence
Independence, Kansas, 67301
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Address
Cancer Center of Kansas-Kingman
Kingman, Kansas, 67068
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Address
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
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Address
Cancer Center of Kansas-Liberal
Liberal, Kansas, 67901
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Address
Cancer Center of Kansas-Manhattan
Manhattan, Kansas, 66502
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Cancer Center of Kansas - McPherson
McPherson, Kansas, 67460
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Address
Cancer Center of Kansas - Newton
Newton, Kansas, 67114
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Address
Cancer Center of Kansas - Parsons
Parsons, Kansas, 67357
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Address
Cancer Center of Kansas - Pratt
Pratt, Kansas, 67124
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Address
Cancer Center of Kansas - Salina
Salina, Kansas, 67401
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Address
Cancer Center of Kansas - Wellington
Wellington, Kansas, 67152
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Address
Associates In Womens Health
Wichita, Kansas, 67208
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Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
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Address
Cancer Center of Kansas - Main Office
Wichita, Kansas, 67214
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Address
Via Christi Regional Medical Center
Wichita, Kansas, 67214
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Address
Wichita CCOP
Wichita, Kansas, 67214
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Address
Cancer Center of Kansas - Winfield
Winfield, Kansas, 67156
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Address
Oncology Hematology Care Incorporated
Crestview Hills, Kentucky, 41017
Status
Address
Ochsner Health Center-Summa
Baton Rouge, Louisiana, 70809
Status
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
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Address
Boston Medical Center
Boston, Massachusetts, 02118
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Address
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
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Address
Bixby Medical Center
Adrian, Michigan, 49221
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Address
Hickman Cancer Center
Adrian, Michigan, 49221
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Address
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106-0995
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Address
Michigan Cancer Research Consortium Community Clinical Oncology Program
Ann Arbor, Michigan, 48106
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Address
University of Michigan University Hospital
Ann Arbor, Michigan, 48109
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Address
Oakwood Hospital
Dearborn, Michigan, 48124
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Address
Saint John Hospital and Medical Center
Detroit, Michigan, 48236
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Address
Hurley Medical Center
Flint, Michigan, 48502
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Address
Genesys Hurley Cancer Institute
Flint, Michigan, 48503
Status
Address
Allegiance Health
Jackson, Michigan, 49201
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Address
Borgess Medical Center
Kalamazoo, Michigan, 49001
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Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
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Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
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Address
Sparrow Hospital
Lansing, Michigan, 48912
Status
Address
Saint Mary Mercy Hospital
Livonia, Michigan, 48154
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Address
Community Cancer Center of Monroe
Monroe, Michigan, 48162
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Address
Mercy Memorial Hospital
Monroe, Michigan, 48162
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Address
Saint Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985
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Address
Saint Joseph Mercy Port Huron
Port Huron, Michigan, 48060
Status
Address
Saint Mary's of Michigan
Saginaw, Michigan, 48601
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Address
Saint John Macomb-Oakland Hospital
Warren, Michigan, 48093
Status
Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
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Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
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Address
Fairview-Southdale Hospital
Edina, Minnesota, 55435
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Address
Unity Hospital
Fridley, Minnesota, 55432
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Address
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
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Address
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
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Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Status
Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
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Address
New Ulm Medical Center
New Ulm, Minnesota, 56073
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Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
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Address
Metro-Minnesota CCOP
Saint Louis Park, Minnesota, 55416
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Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
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Address
Regions Hospital
Saint Paul, Minnesota, 55101
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Address
United Hospital
Saint Paul, Minnesota, 55102
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Address
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
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Address
Lakeview Hospital
Stillwater, Minnesota, 55082
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Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
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Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology and Hematology PA-Woodbury
Woodbury, Minnesota, 55125
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Address
Central Care Cancer Center-Carrie J Babb Cancer Center
Bolivar, Missouri, 65613
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Address
CoxHealth Cancer Center
Branson, Missouri, 65616
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Address
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Status
Address
Southeast Cancer Center
Cape Girardeau, Missouri, 63703
Status
Address
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City, Missouri, 65109
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Address
Phelps County Regional Medical Center
Rolla, Missouri, 65401
Status
Address
Saint John's Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Status
Address
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri, 63109
Status
Address
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
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Address
Saint John's Mercy Medical Center
Saint Louis, Missouri, 63141
Status
Address
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield
Springfield, Missouri, 65802
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Address
Mercy Hospital Springfield
Springfield, Missouri, 65804
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Address
CoxHealth South Hospital
Springfield, Missouri, 65807
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Address
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
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Address
Nevada Cancer Research Foundation CCOP
Las Vegas, Nevada, 89106
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Address
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
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Address
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
Mount Holly, New Jersey, 08060
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Address
Virtua West Jersey Hospital Voorhees
Voorhees, New Jersey, 08043
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Address
New York Oncology Hematology PC - Albany
Albany, New York, 12206
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Address
New York Oncology Hematology PC -Albany Medical Center
Albany, New York, 12208
Status
Address
New York Oncology Hematology PC - Amsterdam
Amsterdam, New York, 12010
Status
Address
Montefiore Medical Center-Weiler Division
Bronx, New York, 10461
Status
Address
Montefiore Medical Center
Bronx, New York, 10467-2490
Status
Address
New York Oncology Hematology PC-Hudson
Hudson, New York, 12534
Status
Address
New York Oncology Hematology PC - Latham
Latham, New York, 12110
Status
Address
New York Oncology Hematology PC - Rexford
Rexford, New York, 12148
Status
Address
University of Rochester
Rochester, New York, 14642
Status
Address
New York Oncology Hematology PC - Troy
Troy, New York, 12180
Status
Address
Kinston Medical Specialists PA
Kinston, North Carolina, 28501
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Address
Iredell Memorial Hospital
Statesville, North Carolina, 28677
Status
Address
Akron General Medical Center
Akron, Ohio, 44307
Status
Address
Cleveland Clinic Cancer Center Beachwood
Beachwood, Ohio, 44122
Status
Address
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
Status
Address
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green, Ohio, 43402
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Status
Address
Oncology and Hematology Care Incorporated
Cincinnati, Ohio, 45219
Status
Address
Oncology Hematology Care Inc - Anderson
Cincinnati, Ohio, 45230
Status
Address
Oncology Hematology Care Inc - Kenwood
Cincinnati, Ohio, 45236
Status
Address
Oncology and Hematology Care Inc - Blue Ash
Cincinnati, Ohio, 45242
Status
Address
Oncology Hematology Care Inc - Western Hills
Cincinnati, Ohio, 45248
Status
Address
University of Cincinnati
Cincinnati, Ohio, 45267
Status
Address
Case Western Reserve University
Cleveland, Ohio, 44106
Status
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Address
Ohio State University Medical Center
Columbus, Ohio, 43210
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
Status
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Address
Columbus CCOP
Columbus, Ohio, 43215
Status
Address
Grant Medical Center
Columbus, Ohio, 43215
Status
Address
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Status
Address
Mount Carmel Health Center West
Columbus, Ohio, 43222
Status
Address
Doctors Hospital
Columbus, Ohio, 43228
Status
Address
Grandview Hospital
Dayton, Ohio, 45405
Status
Address
Good Samaritan Hospital - Dayton
Dayton, Ohio, 45406
Status
Address
Miami Valley Hospital
Dayton, Ohio, 45409
Status
Address
Samaritan North Health Center
Dayton, Ohio, 45415
Status
Address
Dayton CCOP
Dayton, Ohio, 45420
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
Status
Address
Delaware Radiation Oncology
Delaware, Ohio, 43015
Status
Address
Grady Memorial Hospital
Delaware, Ohio, 43015
Status
Address
Hematology Oncology Center Incorporated
Elyria, Ohio, 44035
Status
Address
Mercy Cancer Center-Elyria
Elyria, Ohio, 44035
Status
Address
Oncology Hematology Care Inc
Fairfield, Ohio, 45014
Status
Address
Blanchard Valley Hospital
Findlay, Ohio, 45840
Status
Address
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
Status
Address
Wayne Hospital
Greenville, Ohio, 45331
Status
Address
Cleveland Clinic Cancer Center Independence
Independence, Ohio, 44131
Status
Address
Kettering Medical Center
Kettering, Ohio, 45429
Status
Address
Fairfield Medical Center
Lancaster, Ohio, 43130
Status
Address
Lancaster Radiation Oncology
Lancaster, Ohio, 43130
Status
Address
Saint Rita's Medical Center
Lima, Ohio, 45801
Status
Address
Lima Memorial Hospital
Lima, Ohio, 45804
Status
Address
Marietta Memorial Hospital
Marietta, Ohio, 45750
Status
Address
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
Status
Address
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee, Ohio, 43537
Status
Address
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124
Status
Address
Knox Community Hospital
Mount Vernon, Ohio, 43050
Status
Address
Licking Memorial Hospital
Newark, Ohio, 43055
Status
Address
Newark Radiation Oncology
Newark, Ohio, 43055
Status
Address
Saint Charles Hospital
Oregon, Ohio, 43616
Status
Address
Toledo Clinic Cancer Centers-Oregon
Oregon, Ohio, 43616
Status
Address
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
Status
Address
North Coast Cancer Care
Sandusky, Ohio, 44870
Status
Address
Springfield Regional Medical Center
Springfield, Ohio, 45505
Status
Address
Cleveland Clinic Cancer Center-Strongsville
Strongsville, Ohio, 44136
Status
Address
Flower Hospital
Sylvania, Ohio, 43560
Status
Address
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883
Status
Address
The Toledo Hospital/Toledo Children's Hospital
Toledo, Ohio, 43606
Status
Address
Saint Vincent Mercy Medical Center
Toledo, Ohio, 43608
Status
Address
University of Toledo
Toledo, Ohio, 43614
Status
Address
Toledo Community Hospital Oncology Program CCOP
Toledo, Ohio, 43617
Status
Address
Mercy Saint Anne Hospital
Toledo, Ohio, 43623
Status
Address
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
Status
Address
Upper Valley Medical Center
Troy, Ohio, 45373
Status
Address
Fulton County Health Center
Wauseon, Ohio, 43567
Status
Address
Saint Ann's Hospital
Westerville, Ohio, 43081
Status
Address
Greene Memorial Hospital
Xenia, Ohio, 45385
Status
Address
Genesis HealthCare System
Zanesville, Ohio, 43701
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Address
Tulsa Cancer Institute
Tulsa, Oklahoma, 74146
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822-2001
Status
Address
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201
Status
Address
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
Status
Address
Geisinger Medical Oncology at Evangelical Community Hospital
Lewisburg, Pennsylvania, 17837
Status
Address
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Status
Address
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
Status
Address
Geisinger Medical Oncology-Pottsville
Pottsville, Pennsylvania, 17901
Status
Address
Geisinger Medical Group
State College, Pennsylvania, 16801
Status
Address
Reading Hospital
West Reading, Pennsylvania, 19611
Status
Address
Geisinger Wyoming Valley
Wilkes-Barre, Pennsylvania, 18711
Status
Address
Greenville Health System Cancer Institute-Butternut
Greenville, South Carolina, 29605
Status
Address
Greenville Health System Cancer Institute/Greenville CCOP
Greenville, South Carolina, 29615
Status
Address
Greenville Health System Cancer Institute-Greer
Greer, South Carolina, 29650
Status
Address
Vanderbilt Cancer Center
Nashville, Tennessee, 37232-6838
Status
Address
Fredericksburg Oncology Inc
Fredericksburg, Virginia, 22401
Status
Address
Gundersen Lutheran
La Crosse, Wisconsin, 54601
Status
Address
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792
Status
Address
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Address
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
