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Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors
Study Purpose
This randomized phase II trial studies how well giving temozolomide with or without capecitabine works in treating patients with advanced pancreatic neuroendocrine tumors. Drugs used in chemotherapy, such as temozolomide and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without capecitabine in treating patients with advanced pancreatic neuroendocrine tumors.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patient must have histologically or pathologically confirmed locally unresectable or metastatic low or intermediate grade pancreatic neuroendocrine tumor.
- - Patient must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained <= 4 weeks prior to randomization and must be acquired by multiphasic CT or contrast magnetic resonance imaging (MRI) - Date of last documented disease progression must be within 12 months from date of randomization.
- - Prior everolimus and/or sunitinib therapy is allowed, so long as it was discontinued >= 4 weeks prior to randomization.
- - Concurrent somatostatin analogues are allowed provided that patients.
- - Have been on a stable dose for 8 weeks and.
- - Have documented disease progression on that dose.
- - Chemoembolization is allowed if ≥ 4 weeks from study entry.
- - If patient has hepatic disease only: they need to have progressed in the liver since chemoembolization and have measurable disease by RECIST 1.1 in order to be eligible.
- - If patient has hepatic and extrahepatic disease: they will need to have progressed inside OR outside the liver and have measureable disease by RECIST 1.1 in order to be eligible.
- - Leukocytes >= 3,000/mm^3.
- - Absolute neutrophil count >= 1,500/mm^3.
- - Hemoglobin >= 9 g/dL.
- - Platelets >= 100,000/mm^3.
- - Total bilirubin <= institutional upper limit of normal (ULN) or <= 1.5 X institutional ULN (if the patient has liver metastases) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) <= 3 X institutional ULN or (<= 5 X institutional ULN if the patient has liver metastases) - Serum creatinine <= 1.5 X institutional ULN.
- - Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- - Patient must have life expectancy >= 12 weeks all females of childbearing potential must have a blood test or urine study within =< 2 weeks prior to randomization to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: - Has not undergone a hysterectomy or bilateral oophorectomy; or.
- - Has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) - Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study; should a woman become pregnant while participating in this study, she should inform her treating physician immediately; if a man impregnates a woman while participating in this study, he should inform his treating physician immediately.
- - Patient must be able to swallow pills.
- - Patient must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for their treatment and the protocol.
Exclusion Criteria:
- - Small cell carcinoma.
- - Prior temozolomide, dacarbazine (DTIC), or capecitabine, or 5-FU (fluorouracil) therapy.
- - Receiving any other investigational agents while on study treatment.
- - Receiving Coumadin while on treatment; other anticoagulants are allowed.
- - Patients with either clinically apparent central nervous system metastases or carcinomatous meningitis are ineligible.
- - Active or uncontrolled infection or serious medical or psychiatric illness.
- - History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or capecitabine.
- - Absorption issues that would limit the ability to absorb study agents.
- - Patients with a history of the following within 12 months of study entry: - Arterial thromboembolic events.
- - Unstable angina.
- - Myocardial Infarction.
- - Symptomatic peripheral vascular disease.
- - Patients with previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions: - Non-melanoma skin cancer, in situ cervical cancer, or breast cancer in situ OR.
- - Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR.
- - Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT01824875 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
ECOG-ACRIN Cancer Research Group |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Pamela Kunz |
| Principal Investigator Affiliation | ECOG-ACRIN Cancer Research Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Gastrinoma, Glucagonoma, Insulinoma, Islet Cell Carcinoma, Pancreatic Polypeptide Tumor, Recurrent Islet Cell Carcinoma, Somatostatinoma |
PRIMARY OBJECTIVES:
- I. To evaluate progression-free survival (PFS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.
- I. To evaluate response rates (RR) associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.
- II. To evaluate overall survival (OS) associated with temozolomide alone or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors.
- III. To evaluate the toxicity associated with temozolomide alone or temozolomide and capecitabine treatment in patients with advanced pancreatic neuroendocrine tumors.
- IV. To evaluate the usefulness of methyl guanine methyltransferase (MGMT) status (by immunohistochemistry [IHC] and promoter methylation) for predicting response in pancreatic neuroendocrine tumor patients treated with either temozolomide or temozolomide and capecitabine.
- V. To bank radiology images for evaluation of quality, reproducibility, and compliance with computed tomography (CT) methodology.
Arms
Experimental: Arm A (temozolomide)
Patients receive temozolomide PO QD on days 1-5. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Experimental: Arm B (temozolomide and capecitabine)
Patients receive capecitabine PO BID on days 1-14 and temozolomide PO QD on days 10-14. Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or unacceptable toxicity.
Interventions
Drug: - temozolomide
Given PO
Drug: - capecitabine
Given PO
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Kaiser Anaheim Medical Center
Anaheim 5323810, California 5332921, 92807
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Kaiser Permanente-Deer Valley Medical Center
Antioch 5324200, California 5332921, 94531
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Kaiser Permanente Medical Group - Baldwin Park
Baldwin Park 5325866, California 5332921, 91706
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Kaiser Foundation Hospital
Bellflower 5327422, California 5332921, 90706
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Alta Bates Summit Medical Center-Herrick Campus
Berkeley 5327684, California 5332921, 94704
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Mills - Peninsula Hospitals
Burlingame 5331920, California 5332921, 94010
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Address
Kaiser Permanente Hospital
Fontana 5349755, California 5332921, 92335
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Address
Kaiser Permanente, Fremont
Fremont 5350734, California 5332921, 94538
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Kaiser Permanente
Fresno 5350937, California 5332921, 93720
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Kaiser Permanente - Harbor City
Harbor City 5355325, California 5332921, 90710
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Kaiser Permanente, Hayward
Hayward 5355933, California 5332921, 94545
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Southern California Permanente Medical Group
Irvine 5359777, California 5332921, 92618
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Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921, 90027
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University of Southern California/Norris Cancer Center
Los Angeles 5368361, California 5332921, 90033
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Kaiser Permanente-West Los Angeles
Los Angeles 5368361, California 5332921, 90034
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Cedars-Sinai Medical Center
Los Angeles 5368361, California 5332921, 90048
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Address
Kaiser Permanente-Modesto
Modesto 5373900, California 5332921, 95356
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Sutter Cancer Research Consortium
Novato 5378044, California 5332921, 94945
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Address
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921, 94611
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Address
University of California Medical Center At Irvine-Orange Campus
Orange 5379513, California 5332921, 92868
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Address
Kaiser Permanente - Panorama City
Panorama City 5380932, California 5332921, 91402
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Address
Kaiser Permanente-Redwood City
Redwood City 5386834, California 5332921, 94063
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Address
Kaiser Permanente-Richmond
Richmond 5387428, California 5332921, 94801
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Address
Kaiser Permanente Medical Center
Riverside 5387877, California 5332921, 92505
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Address
Kaiser Permanente-Roseville
Roseville 5388881, California 5332921, 95661
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Address
Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921, 95823
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Address
Kaiser Permanente - Sacramento
Sacramento 5389489, California 5332921, 95825
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Address
Kaiser Permanente at San Diego
San Diego 5391811, California 5332921, 92120
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Address
Kaiser Permanente
San Diego 5391811, California 5332921, 92120
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Address
Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921, 94115
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Address
UCSF-Mount Zion
San Francisco 5391959, California 5332921, 94115
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California Pacific Medical Center
San Francisco 5391959, California 5332921, 94118
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Address
Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921, 95119
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Address
Kaiser Permanente Health Care
San Marcos 5392368, California 5332921, 92069
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Address
Kaiser Permanente-San Rafael
San Rafael 5392567, California 5332921, 94903
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Address
Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921, 95051
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Address
Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921, 95403
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Address
Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921, 95403
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Address
Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921, 94080
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Address
Stanford University Hospitals and Clinics
Stanford 5398563, California 5332921, 94305
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Address
Kaiser Permanente-Stockton
Stockton 5399020, California 5332921, 95210
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Address
Kaiser Permanente Medical Center-Vacaville
Vacaville 5405228, California 5332921, 95688
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Address
Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921, 94589
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Sutter Solano Medical Center
Vallejo 5405380, California 5332921, 94589
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Address
Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921, 94596
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Address
Kaiser Permanente
Woodland Hills 5410438, California 5332921, 91367
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Address
Saint Francis Hospital and Medical Center
Hartford 4835797, Connecticut 4831725, 06105
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Address
Middlesex Hospital
Middletown 4838633, Connecticut 4831725, 06457
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Address
Beebe Medical Center
Lewes 4143354, Delaware 4142224, 19958
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Address
Christiana Gynecologic Oncology LLC
Newark 4143861, Delaware 4142224, 19713
Status
Address
Delaware Clinical and Laboratory Physicians PA
Newark 4143861, Delaware 4142224, 19713
Status
Address
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224, 19713
Status
Address
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224, 19713
Status
Address
Regional Hematology and Oncology PA
Newark 4143861, Delaware 4142224, 19713
Status
Address
Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224, 19718
Status
Address
Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224, 19971
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Address
Nanticoke Memorial Hospital
Seaford 4144600, Delaware 4142224, 19973
Status
Address
Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224, 19801
Status
Address
Edna Williams Cancer Center at the Baptist Cancer Institute
Jacksonville 4160021, Florida 4155751, 32207
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Address
Florida Hospital
Orlando 4167147, Florida 4155751, 32803
Status
Address
H. Lee Moffitt Cancer Center and Research Institute
Tampa 4174757, Florida 4155751, 33612
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Address
Oncare Hawaii Inc-POB II
Honolulu 5856195, Hawaii 5855797, 96813
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Address
Queen's Medical Center
Honolulu 5856195, Hawaii 5855797, 96813
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Address
Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797, 96813
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Address
University of Hawaii
Honolulu 5856195, Hawaii 5855797, 96813
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Address
OnCare Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797, 96817-3169
Status
Address
Oncare Hawaii Inc-Kuakini
Honolulu 5856195, Hawaii 5855797, 96817
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Address
Kaiser Permanente Moanalua Medical Center
Honolulu 5856195, Hawaii 5855797, 96819
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Address
Castle Medical Center
Kailua 5847486, Hawaii 5855797, 96734
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Address
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue 5850248, Hawaii 5855797, 96766
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Address
Oncare Hawaii Inc-Pali Momi
‘Aiea 5856430, Hawaii 5855797, 96701
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Address
Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797, 96701
Status
Address
Saint Alphonsus Regional Medical Center
Boise 5586437, Idaho 5596512, 83706
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Address
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861, 61701
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Address
Saint Joseph Medical Center
Bloomington 4885164, Illinois 4896861, 61701
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Address
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861, 61520
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Address
Memorial Hospital of Carbondale
Carbondale 4235193, Illinois 4896861, 62902
Status
Address
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861, 62321
Status
Address
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861, 62801
Status
Address
Northwestern University
Chicago 4887398, Illinois 4896861, 60611
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Address
University of Illinois
Chicago 4887398, Illinois 4896861, 60612
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Address
Cancer Care Center of Decatur
Decatur 4236895, Illinois 4896861, 62526
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Address
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861, 62526
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Address
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861, 62401
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Address
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861, 61530
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Address
Illinois CancerCare Galesburg
Galesburg 4893392, Illinois 4896861, 61401
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Address
Illinois CancerCare-Galesburg Cottage Plaza Office
Galesburg 4893392, Illinois 4896861, 61401
Status
Address
Hematology Oncology Associates of Illinois-Highland Park
Highland Park 4895876, Illinois 4896861, 60035
Status
Address
Hinsdale Hematology Oncology Associates Incorporated
Hinsdale 4896012, Illinois 4896861, 60521
Status
Address
Presence Saint Mary's Hospital
Kankakee 4898182, Illinois 4896861, 60901
Status
Address
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861, 61443
Status
Address
North Shore Hematology Oncology
Libertyville 4899739, Illinois 4896861, 60048
Status
Address
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861, 61455
Status
Address
Loyola University Medical Center
Maywood 4901514, Illinois 4896861, 60153
Status
Address
Garneau, Stewart C MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
Status
Address
Porubcin, Michael MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
Status
Address
Spector, David MD (UIA Investigator)
Moline 4902476, Illinois 4896861, 61265
Status
Address
Trinity Medical Center
Moline 4902476, Illinois 4896861, 61265
Status
Address
Illinois CancerCare-Monmouth
Monmouth 4902512, Illinois 4896861, 61462
Status
Address
Good Samaritan Regional Health Center
Mount Vernon 4245152, Illinois 4896861, 62864
Status
Address
Illinois Cancer Specialists-Niles
Niles 4903730, Illinois 4896861, 60714
Status
Address
Community Cancer Center Foundation
Normal 4903780, Illinois 4896861, 61761
Status
Address
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861, 61350
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Address
Ottawa Regional Hospital and Healthcare Center
Ottawa 4905006, Illinois 4896861, 61350
Status
Address
Pekin Cancer Treatment Center
Pekin 4905599, Illinois 4896861, 61554
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Address
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861, 61603
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Address
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861, 61603
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Address
Proctor Hospital
Peoria 4905687, Illinois 4896861, 61614
Status
Address
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861, 61615
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Address
Illinois Oncology Research Association CCOP
Peoria 4905687, Illinois 4896861, 61615
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Address
OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861, 61637
Status
Address
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861, 61354
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Address
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861, 61356
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Address
SwedishAmerican Regional Cancer Center/ACT
Rockford 4907959, Illinois 4896861, 61107
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Address
Hematology Oncology Associates of Illinois - Skokie
Skokie 4911600, Illinois 4896861, 60076
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Address
Memorial Medical Center
Springfield 4250542, Illinois 4896861, 62781-0001
Status
Address
Franciscan Saint Francis Health-Indianapolis
Indianapolis 4259418, Indiana 4921868, 46237
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Address
Reid Hospital and Health Care Services
Richmond 4263681, Indiana 4921868, 47374
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Address
Mary Greeley Medical Center
Ames 4846834, Iowa 4862182, 50010
Status
Address
McFarland Clinic PC-William R Bliss Cancer Center
Ames 4846834, Iowa 4862182, 50010
Status
Address
Constantinou, Costas L MD (UIA Investigator)
Bettendorf 4848489, Iowa 4862182, 52722
Status
Address
McFarland Clinic PC-Boone
Boone 4849051, Iowa 4862182, 50036
Status
Address
Medical Oncology and Hematology Associates-West Des Moines
Clive 4852065, Iowa 4862182, 50325
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Address
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182, 50325
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Address
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182, 50309
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Address
Iowa Oncology Research Association CCOP
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
Medical Oncology and Hematology Associates-Des Moines
Des Moines 4853828, Iowa 4862182, 50309
Status
Address
Medical Oncology and Hematology Associates-Laurel
Des Moines 4853828, Iowa 4862182, 50314
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Address
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182, 50314
Status
Address
Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182, 50316
Status
Address
McFarland Clinic PC-Jefferson
Jefferson 4862482, Iowa 4862182, 50129
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Address
McFarland Clinic PC-Marshalltown
Marshalltown 4866371, Iowa 4862182, 50158
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Address
Siouxland Hematology Oncology Associates
Sioux City 4876523, Iowa 4862182, 51101
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Address
Mercy Medical Center-Sioux City
Sioux City 4876523, Iowa 4862182, 51104
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Address
Saint Luke's Regional Medical Center
Sioux City 4876523, Iowa 4862182, 51104
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Address
Methodist West Hospital
West Des Moines 4881346, Iowa 4862182, 50266-7700
Status
Address
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182, 50266
Status
Address
Cancer Center of Kansas - Chanute
Chanute 4269392, Kansas 4273857, 66720
Status
Address
Cancer Center of Kansas - Dodge City
Dodge City 5445298, Kansas 4273857, 67801
Status
Address
Cancer Center of Kansas - El Dorado
El Dorado 4270863, Kansas 4273857, 67042
Status
Address
Cancer Center of Kansas - Fort Scott
Fort Scott 4271690, Kansas 4273857, 66701
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Address
Cancer Center of Kansas-Independence
Independence 4273359, Kansas 4273857, 67301
Status
Address
Cancer Center of Kansas-Kingman
Kingman 4273978, Kansas 4273857, 67068
Status
Address
Lawrence Memorial Hospital
Lawrence 4274277, Kansas 4273857, 66044
Status
Address
Cancer Center of Kansas-Liberal
Liberal 5445820, Kansas 4273857, 67901
Status
Address
Cancer Center of Kansas-Manhattan
Manhattan 4274994, Kansas 4273857, 66502
Status
Address
Cancer Center of Kansas - McPherson
McPherson 4275261, Kansas 4273857, 67460
Status
Address
Cancer Center of Kansas - Newton
Newton 4276248, Kansas 4273857, 67114
Status
Address
Cancer Center of Kansas - Parsons
Parsons 4277011, Kansas 4273857, 67357
Status
Address
Cancer Center of Kansas - Pratt
Pratt 4277752, Kansas 4273857, 67124
Status
Address
Cancer Center of Kansas - Salina
Salina 4278890, Kansas 4273857, 67401
Status
Address
Cancer Center of Kansas - Wellington
Wellington 4281386, Kansas 4273857, 67152
Status
Address
Associates In Womens Health
Wichita 4281730, Kansas 4273857, 67208
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita 4281730, Kansas 4273857, 67208
Status
Address
Cancer Center of Kansas - Main Office
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Via Christi Regional Medical Center
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Wichita CCOP
Wichita 4281730, Kansas 4273857, 67214
Status
Address
Cancer Center of Kansas - Winfield
Winfield 4281897, Kansas 4273857, 67156
Status
Address
Oncology Hematology Care Incorporated
Crestview Hills 4289040, Kentucky 6254925, 41017
Status
Address
Ochsner Health Center-Summa
Baton Rouge 4315588, Louisiana 4331987, 70809
Status
Address
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987, 70121
Status
Address
Boston Medical Center
Boston 4930956, Massachusetts 6254926, 02118
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Address
Lahey Hospital and Medical Center
Burlington 4931737, Massachusetts 6254926, 01805
Status
Address
Bixby Medical Center
Adrian 4983811, Michigan 5001836, 49221
Status
Address
Hickman Cancer Center
Adrian 4983811, Michigan 5001836, 49221
Status
Address
Saint Joseph Mercy Hospital
Ann Arbor 4984247, Michigan 5001836, 48106-0995
Status
Address
Michigan Cancer Research Consortium Community Clinical Oncology Program
Ann Arbor 4984247, Michigan 5001836, 48106
Status
Address
University of Michigan University Hospital
Ann Arbor 4984247, Michigan 5001836, 48109
Status
Address
Oakwood Hospital
Dearborn 4990510, Michigan 5001836, 48124
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Address
Saint John Hospital and Medical Center
Detroit 4990729, Michigan 5001836, 48236
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Address
Hurley Medical Center
Flint 4992982, Michigan 5001836, 48502
Status
Address
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836, 48503
Status
Address
Allegiance Health
Jackson 4997384, Michigan 5001836, 49201
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Address
Borgess Medical Center
Kalamazoo 4997787, Michigan 5001836, 49001
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Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
Status
Address
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
Sparrow Hospital
Lansing 4998830, Michigan 5001836, 48912
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Address
Saint Mary Mercy Hospital
Livonia 4999837, Michigan 5001836, 48154
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Address
Community Cancer Center of Monroe
Monroe 5002344, Michigan 5001836, 48162
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Address
Mercy Memorial Hospital
Monroe 5002344, Michigan 5001836, 48162
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Address
Saint Joseph Mercy Oakland
Pontiac 5006166, Michigan 5001836, 48341-2985
Status
Address
Saint Joseph Mercy Port Huron
Port Huron 5006233, Michigan 5001836, 48060
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Address
Saint Mary's of Michigan
Saginaw 5007989, Michigan 5001836, 48601
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Address
Saint John Macomb-Oakland Hospital
Warren 5014051, Michigan 5001836, 48093
Status
Address
Fairview Ridges Hospital
Burnsville 5019767, Minnesota 5037779, 55337
Status
Address
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779, 55433
Status
Address
Fairview-Southdale Hospital
Edina 5025264, Minnesota 5037779, 55435
Status
Address
Unity Hospital
Fridley 5027482, Minnesota 5037779, 55432
Status
Address
Hutchinson Area Health Care
Hutchinson 5030977, Minnesota 5037779, 55350
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779, 55407
Status
Address
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779, 55415
Status
Address
New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779, 56073
Status
Address
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779, 55422
Status
Address
Metro-Minnesota CCOP
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779, 55416
Status
Address
Regions Hospital
Saint Paul 5045360, Minnesota 5037779, 55101
Status
Address
United Hospital
Saint Paul 5045360, Minnesota 5037779, 55102
Status
Address
Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779, 55379
Status
Address
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779, 55082
Status
Address
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779, 55387
Status
Address
Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779, 56201
Status
Address
Minnesota Oncology and Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779, 55125
Status
Address
Central Care Cancer Center-Carrie J Babb Cancer Center
Bolivar 4377835, Missouri 4398678, 65613
Status
Address
CoxHealth Cancer Center
Branson 4378219, Missouri 4398678, 65616
Status
Address
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678, 63703
Status
Address
Southeast Cancer Center
Cape Girardeau 4379966, Missouri 4398678, 63703
Status
Address
Capital Region Medical Center-Goldschmidt Cancer Center
Jefferson City 4392388, Missouri 4398678, 65109
Status
Address
Phelps County Regional Medical Center
Rolla 4406282, Missouri 4398678, 65401
Status
Address
Saint John's Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678, 65401
Status
Address
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield
Springfield 4409896, Missouri 4398678, 65802
Status
Address
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678, 65804
Status
Address
CoxHealth South Hospital
Springfield 4409896, Missouri 4398678, 65807
Status
Address
Saint Louis Cancer and Breast Institute-South City
St Louis 4407066, Missouri 4398678, 63109
Status
Address
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678, 63131
Status
Address
Saint John's Mercy Medical Center
St Louis 4407066, Missouri 4398678, 63141
Status
Address
Nebraska Methodist Hospital
Omaha 5074472, Nebraska 5073708, 68114
Status
Address
Nevada Cancer Research Foundation CCOP
Las Vegas 5506956, Nevada 5509151, 89106
Status
Address
Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760, 08103
Status
Address
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
Mount Holly 4503134, New Jersey 5101760, 08060
Status
Address
Virtua West Jersey Hospital Voorhees
Voorhees Township 5105860, New Jersey 5101760, 08043
Status
Address
New York Oncology Hematology PC - Albany
Albany 5106834, New York 5128638, 12206
Status
Address
New York Oncology Hematology PC -Albany Medical Center
Albany 5106834, New York 5128638, 12208
Status
Address
New York Oncology Hematology PC - Amsterdam
Amsterdam 5107152, New York 5128638, 12010
Status
Address
New York Oncology Hematology PC-Hudson
Hudson 5121509, New York 5128638, 12534
Status
Address
New York Oncology Hematology PC - Latham
Latham 5124045, New York 5128638, 12110
Status
Address
New York Oncology Hematology PC - Rexford
Rexford 5133716, New York 5128638, 12148
Status
Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
Status
Address
Montefiore Medical Center-Weiler Division
The Bronx 5110266, New York 5128638, 10461
Status
Address
Montefiore Medical Center
The Bronx 5110266, New York 5128638, 10467-2490
Status
Address
New York Oncology Hematology PC - Troy
Troy 5141502, New York 5128638, 12180
Status
Address
Kinston Medical Specialists PA
Kinston 4474436, North Carolina 4482348, 28501
Status
Address
Iredell Memorial Hospital
Statesville 4493316, North Carolina 4482348, 28677
Status
Address
Akron General Medical Center
Akron 5145476, Ohio 5165418, 44307
Status
Address
Cleveland Clinic Cancer Center Beachwood
Beachwood 5146711, Ohio 5165418, 44122
Status
Address
Strecker Cancer Center-Belpre
Belpre 4506187, Ohio 5165418, 45714
Status
Address
Toledo Clinic Cancer Centers-Bowling Green
Bowling Green 5147968, Ohio 5165418, 43402
Status
Address
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418, 45601
Status
Address
Oncology and Hematology Care Incorporated
Cincinnati 4508722, Ohio 5165418, 45219
Status
Address
Oncology Hematology Care Inc - Anderson
Cincinnati 4508722, Ohio 5165418, 45230
Status
Address
Oncology Hematology Care Inc - Kenwood
Cincinnati 4508722, Ohio 5165418, 45236
Status
Address
Oncology and Hematology Care Inc - Blue Ash
Cincinnati 4508722, Ohio 5165418, 45242
Status
Address
Oncology Hematology Care Inc - Western Hills
Cincinnati 4508722, Ohio 5165418, 45248
Status
Address
University of Cincinnati
Cincinnati 4508722, Ohio 5165418, 45267
Status
Address
Case Western Reserve University
Cleveland 5150529, Ohio 5165418, 44106
Status
Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
Status
Address
Ohio State University Medical Center
Columbus 4509177, Ohio 5165418, 43210
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418, 43214
Status
Address
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418, 43214
Status
Address
Columbus CCOP
Columbus 4509177, Ohio 5165418, 43215
Status
Address
Grant Medical Center
Columbus 4509177, Ohio 5165418, 43215
Status
Address
The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418, 43219
Status
Address
Mount Carmel Health Center West
Columbus 4509177, Ohio 5165418, 43222
Status
Address
Doctors Hospital
Columbus 4509177, Ohio 5165418, 43228
Status
Address
Grandview Hospital
Dayton 4509884, Ohio 5165418, 45405
Status
Address
Good Samaritan Hospital - Dayton
Dayton 4509884, Ohio 5165418, 45406
Status
Address
Miami Valley Hospital
Dayton 4509884, Ohio 5165418, 45409
Status
Address
Samaritan North Health Center
Dayton 4509884, Ohio 5165418, 45415
Status
Address
Dayton CCOP
Dayton 4509884, Ohio 5165418, 45420
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Delaware Radiation Oncology
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Hematology Oncology Center Incorporated
Elyria 5153207, Ohio 5165418, 44035
Status
Address
Mercy Cancer Center-Elyria
Elyria 5153207, Ohio 5165418, 44035
Status
Address
Oncology Hematology Care Inc
Fairfield 4511283, Ohio 5165418, 45014
Status
Address
Blanchard Valley Hospital
Findlay 5153924, Ohio 5165418, 45840
Status
Address
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418, 45005-1066
Status
Address
Wayne Hospital
Greenville 5156493, Ohio 5165418, 45331
Status
Address
Cleveland Clinic Cancer Center Independence
Independence 5158404, Ohio 5165418, 44131
Status
Address
Kettering Medical Center
Kettering 4515843, Ohio 5165418, 45429
Status
Address
Fairfield Medical Center
Lancaster 4516233, Ohio 5165418, 43130
Status
Address
Lancaster Radiation Oncology
Lancaster 4516233, Ohio 5165418, 43130
Status
Address
Saint Rita's Medical Center
Lima 5160783, Ohio 5165418, 45801
Status
Address
Lima Memorial Hospital
Lima 5160783, Ohio 5165418, 45804
Status
Address
Marietta Memorial Hospital
Marietta 4517586, Ohio 5165418, 45750
Status
Address
Toledo Clinic Cancer Centers-Maumee
Maumee 5162137, Ohio 5165418, 43537
Status
Address
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Maumee 5162137, Ohio 5165418, 43537
Status
Address
Hillcrest Hospital Cancer Center
Mayfield Heights 5162188, Ohio 5165418, 44124
Status
Address
Knox Community Hospital
Mount Vernon 5163799, Ohio 5165418, 43050
Status
Address
Licking Memorial Hospital
Newark 5164466, Ohio 5165418, 43055
Status
Address
Newark Radiation Oncology
Newark 5164466, Ohio 5165418, 43055
Status
Address
Saint Charles Hospital
Oregon 5165734, Ohio 5165418, 43616
Status
Address
Toledo Clinic Cancer Centers-Oregon
Oregon 5165734, Ohio 5165418, 43616
Status
Address
Southern Ohio Medical Center
Portsmouth 4521816, Ohio 5165418, 45662
Status
Address
North Coast Cancer Care
Sandusky 5170691, Ohio 5165418, 44870
Status
Address
Springfield Regional Medical Center
Springfield 4525353, Ohio 5165418, 45505
Status
Address
Cleveland Clinic Cancer Center-Strongsville
Strongsville 5173237, Ohio 5165418, 44136
Status
Address
Flower Hospital
Sylvania 5173572, Ohio 5165418, 43560
Status
Address
Mercy Hospital of Tiffin
Tiffin 5173930, Ohio 5165418, 44883
Status
Address
The Toledo Hospital/Toledo Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
Status
Address
Saint Vincent Mercy Medical Center
Toledo 5174035, Ohio 5165418, 43608
Status
Address
University of Toledo
Toledo 5174035, Ohio 5165418, 43614
Status
Address
Toledo Community Hospital Oncology Program CCOP
Toledo 5174035, Ohio 5165418, 43617
Status
Address
Mercy Saint Anne Hospital
Toledo 5174035, Ohio 5165418, 43623
Status
Address
Toledo Clinic Cancer Centers-Toledo
Toledo 5174035, Ohio 5165418, 43623
Status
Address
Upper Valley Medical Center
Troy 5174358, Ohio 5165418, 45373
Status
Address
Fulton County Health Center
Wauseon 5175877, Ohio 5165418, 43567
Status
Address
Saint Ann's Hospital
Westerville 5176472, Ohio 5165418, 43081
Status
Address
Greene Memorial Hospital
Xenia 4528810, Ohio 5165418, 45385
Status
Address
Genesis HealthCare System
Zanesville 4528923, Ohio 5165418, 43701
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Address
Tulsa Cancer Institute
Tulsa 4553433, Oklahoma 4544379, 74146
Status
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822-2001
Status
Address
Geisinger Medical Center-Cancer Center Hazleton
Hazleton 5193011, Pennsylvania 6254927, 18201
Status
Address
Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927, 17033-0850
Status
Address
Geisinger Medical Oncology at Evangelical Community Hospital
Lewisburg 5197842, Pennsylvania 6254927, 17837
Status
Address
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927, 19107
Status
Address
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927, 19111
Status
Address
Geisinger Medical Oncology-Pottsville
Pottsville 5207080, Pennsylvania 6254927, 17901
Status
Address
Geisinger Medical Group
State College 5213681, Pennsylvania 6254927, 16801
Status
Address
Reading Hospital
West Reading 5218867, Pennsylvania 6254927, 19611
Status
Address
Geisinger Wyoming Valley
Wilkes-Barre 5219488, Pennsylvania 6254927, 18711
Status
Address
Greenville Health System Cancer Institute-Butternut
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Greenville Health System Cancer Institute/Greenville CCOP
Greenville 4580543, South Carolina 4597040, 29615
Status
Address
Greenville Health System Cancer Institute-Greer
Greer 4580599, South Carolina 4597040, 29650
Status
Address
Vanderbilt Cancer Center
Nashville 4644585, Tennessee 4662168, 37232-6838
Status
Address
Fredericksburg Oncology Inc
Fredericksburg 4760059, Virginia 6254928, 22401
Status
Address
Gundersen Lutheran
La Crosse 5258957, Wisconsin 5279468, 54601
Status
Address
University of Wisconsin Hospital and Clinics
Madison 5261457, Wisconsin 5279468, 53792
Status
Address
Froedtert and the Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
Status
Address
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468, 54017
