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Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma
Study Purpose
This phase III trial studies how well response and biology-based risk factor-guided therapy works in treating younger patients with non-high risk neuroblastoma. Sometimes a tumor may not need treatment until it progresses. In this case, observation may be sufficient. Measuring biomarkers in tumor cells may help plan when effective treatment is necessary and what the best treatment is. Response and biology-based risk factor-guided therapy may be effective in treating patients with non-high risk neuroblastoma and may help to avoid some of the risks and side effects related to standard treatment.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | N/A - 18 Months |
| Gender | All |
Inclusion Criteria:
- - Patients must be: - < 12 months (< 365 days) of age at diagnosis with INRG stage L1; or.
- - < 18 months (< 547 days) of age at diagnosis with INRG stage L2 or stage Ms neuroblastoma/ganglioneuroblastoma.
- - Enrollment on ANBL00B1 or APEC14B1 is required for all newly diagnosed patients.
- - Patients must have newly diagnosed v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) non-amplified neuroblastoma (International Classification of Diseases for Oncology [ICD-O] morphology 9500/3) or MYCN non-amplified ganglioneuroblastoma verified by histology.
- - Patients must meet the specified criteria for one of the treatment groups defined below; genomic features include MYCN gene amplification, segmental chromosome aberrations (somatic copy number loss at 1p, 3p, 4p, or 11q or somatic copy number gain at 1q, 2p, or 17q) and deoxyribonucleic acid (DNA) index.
- - "Favorable" genomic features are defined by one or more whole-chromosome gains or hyperdiploid tumor (DNA index > 1) in the absence of segmental chromosome aberrations as defined above.
- - "Unfavorable" genomic features are defined by the presence of any segmental chromosome aberration (somatic copy number loss at 1p, 3p, 4p, or 11q or somatic copy number gain at 1q, 2p, or 17q) or diploid tumor (DNA index = 1); this includes copy neutral loss of heterozygosity (LOH) - Only patients with MYCN non-amplified tumors are eligible for this study.
- - Group A: patients < 12 months (< 365 days) of age with newly diagnosed INRG stage L1 neuroblastoma/ganglioneuroblastoma who meet the following criteria: - Greatest tumor diameter < 5 cm of adrenal or non-adrenal origin.
- - Patients with non-adrenal primaries are eligible, but must have positive uptake on metaiodobenzylguanidine (MIBG) scan or elevated catecholamine metabolites (urine or serum) to support the diagnosis of neuroblastoma.
- - No prior tumor resection or biopsy.
- - Group A will be further split into two subsets, which are mutually exclusive, for statistical purposes.
- - Group A1: - > 6 months and < 12 months of age with an adrenal primary tumor < 5 cm in greatest diameter OR.
- - Patients less than 6 months of age with an adrenal primary tumor > 3.1 and < 5 cm in greatest diameter OR.
- - < 12 months of age with a non-adrenal primary site < 5 cm in greatest diameter.
- - Group A2: =< 6 months of age with an adrenal primary site and tumor =< 3.1 cm in greatest diameter.
- - Group B: patients < 18 months (< 547 days) of age with newly diagnosed INRG stage L2 neuroblastoma/ganglioneuroblastoma who meet the following criteria: - No life threatening symptoms or no impending neurologic or other organ function compromise (e.g. epidural or intraspinal tumors with existing or impending neurologic impairment, periorbital or calvarial-based lesions with existing or impending cranial nerve impairment, anatomic or mechanical compromise of critical organ function by tumor [abdominal compartment syndrome, urinary obstruction, etc.]); horner syndrome is not considered neurologic compromise.
- - No prior tumor resection, tumor biopsy ONLY.
- - Only patients with both favorable histology and favorable genomic features will remain on study as part of Group B; the institution will be notified of histologic and genomic results within 3 weeks of specimen submission on ANBL00B1 or APEC14B1.
- - Group C: patients < 18 months (< 547 days) of age with newly diagnosed INRG stage Ms neuroblastoma/ganglioneuroblastoma.
- - No prior radiotherapy or chemotherapy, with the exception of dexamethasone, which is allowed.
- - All patients and/or their parents or legal guardians must sign a written informed consent.
- - All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met.
Exclusion Criteria:
- - Patients with MYCN amplified tumors are not eligible.
- - Group B and C patients who do not enroll on ANBL1232 within 4 weeks of definitive diagnostic procedure.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT02176967 |
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Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Children's Oncology Group |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Holly J Meany |
| Principal Investigator Affiliation | Children's Oncology Group |
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Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Active, not recruiting |
| Countries | Australia, Canada, New Zealand, Puerto Rico, Saudi Arabia, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Neuroblastoma |
PRIMARY OBJECTIVES:
- I. To eliminate therapy as the initial approach for infants < 12 months of age with small International Neuroblastoma Risk Group (INRG) stage L1 neuroblastoma while maintaining an overall survival (OS) of 99%.
- II. To eliminate therapy as the initial approach for non-high-risk patients < 18 months of age with localized neuroblastoma and favorable biology (histologic and genomic features) while maintaining an OS of 99%.
- III. To achieve a 3-year OS of > 81% for infants < 18 months of age with INRG stage Ms neuroblastoma using objective criteria for early initiation of a response-based treatment algorithm.
- I. To describe the time to intervention or tumor progression, type of intervention and site of progression for patients with localized neuroblastoma who experience progression after an initial period of observation.
- II. To characterize the pharmacokinetic profile of the chemotherapeutic agents carboplatin and etoposide in patients with stage Ms disease.
- III. To define the genomic profile of tumors from patients with non-high-risk neuroblastoma both at initial biopsy and at the time of subsequent biopsy or surgical resection.
- IV. To describe the histology of tumor specimens obtained at the time of subsequent biopsy or surgical resection.
- V. To determine the salvage rate (OS) of patients with tumor relapse or disease progression.
- VI. To determine the procedural complication rate (initial biopsy, resection [intraoperative and postoperative], subsequent biopsy) and correlate with the degree of surgical resection.
- VII. To determine the rate of reduction in image defined risk factors (IDRF) in L2 tumors following observation or chemotherapy.
Arms
Experimental: Group A (clinical observation)
Patients undergo clinical observation for 96 weeks in the absence of disease progression. Patients also undergo CT, MRI, and/or ultrasound throughout the trial.
Experimental: Group B (clinical observation, first-line chemotherapy)
Patients undergo clinical observation for 3 years in the absence of disease progression. Upon disease progression, patients undergo surgery or receive first-line chemotherapy comprising carboplatin IV over 1 hour on day 1 (courses 1, 2, 4, 6, and 7), etoposide IV over 1 hour on days 1-3 (courses 1, 3, 4, 5, and 7), cyclophosphamide IV over 1 hour on day 1 (courses 2, 3, 5, 6, and 8), and doxorubicin hydrochloride IV over 15 minutes on day 1 (courses 2, 4, 6 and 8). Treatment with chemotherapy repeats every 21 days for 2-8 courses in the absence of disease progression or unacceptable toxicity. Once a PR or better is achieved, patients undergo clinical observation for 3 years. Patients also undergo CT, MRI, and/or ultrasound throughout the trial and undergo bone marrow aspiration, bone marrow biopsy, and tumor biopsy at screening and time of progression.
Experimental: Group C (clinical observation, first-line chemotherapy)
Patients at high risk for deterioration and a poor outcome immediately receive first-line chemotherapy as in Group B. All other patients undergo clinical observation for 3 years in the absence of disease progression. Upon disease progression, patients receive first-line chemotherapy as in Group B. Once a PR or better is achieved, patients undergo clinical observation for 3 years. Patients also undergo CT, MRI, and/or ultrasound throughout the trial and undergo bone marrow aspiration, bone marrow biopsy, and tumor biopsy at screening and time of progression.
Interventions
Procedure: - Biopsy
Undergo biopsy
Procedure: - Bone Marrow Aspiration
Undergo bone marrow aspiration
Procedure: - Bone Marrow Biopsy
Undergo bone marrow biopsy
Drug: - Carboplatin
Given IV
Other: - Clinical Observation
Undergo clinical observation
Procedure: - Computed Tomography
Undergo CT
Drug: - Cyclophosphamide
Given IV
Drug: - Doxorubicin Hydrochloride
Given IV
Drug: - Etoposide
Given IV
Procedure: - Magnetic Resonance Imaging
Undergo MRI
Procedure: - Ultrasound
Undergo ultrasound
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Children's Hospital of Alabama
Birmingham 4049979, Alabama 4829764, 35233
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Address
USA Health Strada Patient Care Center
Mobile 4076598, Alabama 4829764, 36604
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Address
Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092, 99508
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Address
Banner Children's at Desert
Mesa 5304391, Arizona 5551752, 85202
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Address
Phoenix Childrens Hospital
Phoenix 5308655, Arizona 5551752, 85016
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Address
Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752, 85719
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Address
Arkansas Children's Hospital
Little Rock 4119403, Arkansas 4099753, 72202-3591
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Address
Kaiser Permanente Downey Medical Center
Downey 5343858, California 5332921, 90242
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Address
City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921, 91010
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Address
Loma Linda University Medical Center
Loma Linda 5367696, California 5332921, 92354
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Address
Miller Children's and Women's Hospital Long Beach
Long Beach 5367929, California 5332921, 90806
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Address
Children's Hospital Los Angeles
Los Angeles 5368361, California 5332921, 90027
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Address
Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921, 90048
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Address
Valley Children's Hospital
Madera 5369568, California 5332921, 93636
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Address
UCSF Benioff Children's Hospital Oakland
Oakland 5378538, California 5332921, 94609
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Address
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921, 94611
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Address
Children's Hospital of Orange County
Orange 5379513, California 5332921, 92868
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Address
Lucile Packard Children's Hospital Stanford University
Palo Alto 5380748, California 5332921, 94304
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Address
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921, 95816
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Address
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921, 95817
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Address
Rady Children's Hospital - San Diego
San Diego 5391811, California 5332921, 92123
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Address
Naval Medical Center -San Diego
San Diego 5391811, California 5332921, 92134
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Address
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921, 94158
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Address
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance 5403022, California 5332921, 90502
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Address
Children's Hospital Colorado
Aurora 5412347, Colorado 5417618, 80045
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Address
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver 5419384, Colorado 5417618, 80218
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Address
Connecticut Children's Medical Center
Hartford 4835797, Connecticut 4831725, 06106
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Address
Yale University
New Haven 4839366, Connecticut 4831725, 06520
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Address
Alfred I duPont Hospital for Children
Wilmington 4145381, Delaware 4142224, 19803
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Address
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106, 20007
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Address
Children's National Medical Center
Washington D.C. 4140963, District of Columbia 4138106, 20010
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Address
Broward Health Medical Center
Fort Lauderdale 4155966, Florida 4155751, 33316
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Address
Golisano Children's Hospital of Southwest Florida
Fort Myers 4155995, Florida 4155751, 33908
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Address
University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751, 32610
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Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751, 33021
Status
Address
Nemours Children's Clinic-Jacksonville
Jacksonville 4160021, Florida 4155751, 32207
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Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
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Address
Nicklaus Children's Hospital
Miami 4164138, Florida 4155751, 33155
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Address
Miami Cancer Institute
Miami 4164138, Florida 4155751, 33176
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AdventHealth Orlando
Orlando 4167147, Florida 4155751, 32803
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Arnold Palmer Hospital for Children
Orlando 4167147, Florida 4155751, 32806
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Nemours Children's Hospital
Orlando 4167147, Florida 4155751, 32827
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Address
Nemours Children's Clinic - Pensacola
Pensacola 4168228, Florida 4155751, 32504
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Address
Sacred Heart Hospital
Pensacola 4168228, Florida 4155751, 32504
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Johns Hopkins All Children's Hospital
St. Petersburg 4171563, Florida 4155751, 33701
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Tampa General Hospital
Tampa 4174757, Florida 4155751, 33606
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Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751, 33607
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Address
Saint Mary's Medical Center
West Palm Beach 4177887, Florida 4155751, 33407
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Address
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta 4180439, Georgia 4197000, 30329
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Address
Augusta University Medical Center
Augusta 4180531, Georgia 4197000, 30912
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Address
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000, 31404
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Address
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797, 96826
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Address
Tripler Army Medical Center
Honolulu 5856195, Hawaii 5855797, 96859
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Address
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512, 83712
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Address
Lurie Children's Hospital-Chicago
Chicago 4887398, Illinois 4896861, 60611
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Address
University of Illinois
Chicago 4887398, Illinois 4896861, 60612
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Address
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861, 60637
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Address
Loyola University Medical Center
Maywood 4901514, Illinois 4896861, 60153
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Address
Advocate Children's Hospital-Oak Lawn
Oak Lawn 4904365, Illinois 4896861, 60453
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Address
Advocate Children's Hospital-Park Ridge
Park Ridge 4905367, Illinois 4896861, 60068
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Address
Saint Jude Midwest Affiliate
Peoria 4905687, Illinois 4896861, 61637
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Address
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861, 62702
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Address
IU Health North Hospital
Carmel 4255466, Indiana 4921868, 46032
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Address
Riley Hospital for Children
Indianapolis 4259418, Indiana 4921868, 46202
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Address
Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868, 46260
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Address
Blank Children's Hospital
Des Moines 4853828, Iowa 4862182, 50309
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Address
University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182, 52242
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Address
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925, 40536
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Address
Norton Children's Hospital
Louisville 4299276, Kentucky 6254925, 40202
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Address
Children's Hospital New Orleans
New Orleans 4335045, Louisiana 4331987, 70118
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Address
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987, 70121
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Address
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068, 04401
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Address
Maine Children's Cancer Program
Scarborough 4977882, Maine 4971068, 04074
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Address
Sinai Hospital of Baltimore
Baltimore 4347778, Maryland 4361885, 21215
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Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885, 21287
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Address
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885, 20889-5600
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Address
Tufts Children's Hospital
Boston 4930956, Massachusetts 6254926, 02111
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Address
Massachusetts General Hospital Cancer Center
Boston 4930956, Massachusetts 6254926, 02114
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Address
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926, 02215
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Address
Baystate Medical Center
Springfield 4951788, Massachusetts 6254926, 01199
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Address
UMass Memorial Medical Center - University Campus
Worcester 4956184, Massachusetts 6254926, 01655
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Address
C S Mott Children's Hospital
Ann Arbor 4984247, Michigan 5001836, 48109
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Address
Children's Hospital of Michigan
Detroit 4990729, Michigan 5001836, 48201
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Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
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Address
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836, 48236
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Address
Michigan State University
East Lansing 4991640, Michigan 5001836, 48823
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Address
Hurley Medical Center
Flint 4992982, Michigan 5001836, 48503
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Address
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
Corewell Health Children's
Royal Oak 5007804, Michigan 5001836, 48073
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Address
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis 5037649, Minnesota 5037779, 55404
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Address
University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779, 55455
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Address
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779, 55905
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Address
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296, 39216
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Address
University of Missouri Children's Hospital
Columbia 4381982, Missouri 4398678, 65212
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Address
Children's Mercy Hospitals and Clinics
Kansas City 4393217, Missouri 4398678, 64108
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Address
Cardinal Glennon Children's Medical Center
St Louis 4407066, Missouri 4398678, 63104
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Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
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Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
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Address
Children's Hospital and Medical Center of Omaha
Omaha 5074472, Nebraska 5073708, 68114
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Address
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708, 68198
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Address
University Medical Center of Southern Nevada
Las Vegas 5506956, Nevada 5509151, 89102
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Address
Sunrise Hospital and Medical Center
Las Vegas 5506956, Nevada 5509151, 89109
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Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151, 89135
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Address
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151, 89144
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Address
Renown Regional Medical Center
Reno 5511077, Nevada 5509151, 89502
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Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174, 03756
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Address
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760, 07601
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Address
Morristown Medical Center
Morristown 5101427, New Jersey 5101760, 07960
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Address
Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760, 08901
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Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick 5101717, New Jersey 5101760, 08903
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Address
Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760, 07112
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Address
Saint Joseph's Regional Medical Center
Paterson 5102466, New Jersey 5101760, 07503
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Address
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136, 87106
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Address
Albany Medical Center
Albany 5106834, New York 5128638, 12208
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Address
Maimonides Medical Center
Brooklyn 5110302, New York 5128638, 11219
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Address
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638, 14263
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Address
NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638, 11501
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Address
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park 5128514, New York 5128638, 11040
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Address
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638, 10016
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Address
Mount Sinai Hospital
New York 5128581, New York 5128638, 10029
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Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638, 10032
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Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
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Address
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638, 13210
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Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
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Address
New York Medical College
Valhalla 5142090, New York 5128638, 10595
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Address
Mission Hospital
Asheville 4453066, North Carolina 4482348, 28801
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Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348, 27599
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Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348, 28203
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Address
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348, 28204
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Address
Duke University Medical Center
Durham 4464368, North Carolina 4482348, 27710
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Address
East Carolina University
Greenville 4469160, North Carolina 4482348, 27834
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Address
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348, 27157
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Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
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Address
Children's Hospital Medical Center of Akron
Akron 5145476, Ohio 5165418, 44308
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Address
Cincinnati Children's Hospital Medical Center
Cincinnati 4508722, Ohio 5165418, 45229
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Address
Rainbow Babies and Childrens Hospital
Cleveland 5150529, Ohio 5165418, 44106
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Address
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418, 44195
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Address
Nationwide Children's Hospital
Columbus 4509177, Ohio 5165418, 43205
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Address
Dayton Children's Hospital
Dayton 4509884, Ohio 5165418, 45404
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Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418, 43606
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Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
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Address
Legacy Emanuel Children's Hospital
Portland 5746545, Oregon 5744337, 97227
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Address
Oregon Health and Science University
Portland 5746545, Oregon 5744337, 97239
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Address
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927, 18103
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Address
Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927, 18017
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Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
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Address
Penn State Children's Hospital
Hershey 5193342, Pennsylvania 6254927, 17033
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Address
Children's Hospital of Philadelphia
Philadelphia 4560349, Pennsylvania 6254927, 19104
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Address
Saint Christopher's Hospital for Children
Philadelphia 4560349, Pennsylvania 6254927, 19134
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Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh 5206379, Pennsylvania 6254927, 15224
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Address
Rhode Island Hospital
Providence 5224151, Rhode Island 5224323, 02903
Status
Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Address
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040, 29203
Status
Address
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040, 29605
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Address
T C Thompson Children's Hospital
Chattanooga 4612862, Tennessee 4662168, 37403
Status
Address
East Tennessee Childrens Hospital
Knoxville 4634946, Tennessee 4662168, 37916
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Address
Saint Jude Children's Research Hospital
Memphis 4641239, Tennessee 4662168, 38105
Status
Address
The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168, 37203
Status
Address
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168, 37232
Status
Address
Dell Children's Medical Center of Central Texas
Austin 4671654, Texas 4736286, 78723
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Address
Driscoll Children's Hospital
Corpus Christi 4683416, Texas 4736286, 78411
Status
Address
Medical City Dallas Hospital
Dallas 4684888, Texas 4736286, 75230
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286, 75390
Status
Address
El Paso Children's Hospital
El Paso 5520993, Texas 4736286, 79905
Status
Address
Cook Children's Medical Center
Fort Worth 4691930, Texas 4736286, 76104
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Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286, 77030
Status
Address
Covenant Children's Hospital
Lubbock 5525577, Texas 4736286, 79410
Status
Address
UMC Cancer Center / UMC Health System
Lubbock 5525577, Texas 4736286, 79415
Status
Address
Children's Hospital of San Antonio
San Antonio 4726206, Texas 4736286, 78207
Status
Address
Methodist Children's Hospital of South Texas
San Antonio 4726206, Texas 4736286, 78229
Status
Address
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286, 78229
Status
Address
Scott and White Memorial Hospital
Temple 4735966, Texas 4736286, 76508
Status
Address
Primary Children's Hospital
Salt Lake City 5780993, Utah 5549030, 84113
Status
Address
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283, 05405
Status
Address
University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928, 22908
Status
Address
Inova Fairfax Hospital
Falls Church 4758390, Virginia 6254928, 22042
Status
Address
Children's Hospital of The King's Daughters
Norfolk 4776222, Virginia 6254928, 23507
Status
Address
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Address
Carilion Children's
Roanoke 4782167, Virginia 6254928, 24014
Status
Address
Seattle Children's Hospital
Seattle 5809844, Washington 5815135, 98105
Status
Address
Providence Sacred Heart Medical Center and Children's Hospital
Spokane 5811696, Washington 5815135, 99204
Status
Address
Mary Bridge Children's Hospital and Health Center
Tacoma 5812944, Washington 5815135, 98405
Status
Address
Madigan Army Medical Center
Tacoma 5812944, Washington 5815135, 98431
Status
Address
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850, 25304
Status
Address
Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850, 25701
Status
Address
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850, 26506
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468, 53792
Status
Address
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Children's Hospital of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
International Sites
Status
Address
John Hunter Children's Hospital
Hunter Regional Mail Centre, New South Wales 2155400, 2310
Status
Address
Sydney Children's Hospital
Randwick 2208285, New South Wales 2155400, 2031
Status
Address
The Children's Hospital at Westmead
Westmead 2143973, New South Wales 2155400, 2145
Status
Address
Queensland Children's Hospital
South Brisbane 2207259, Queensland 2152274, 4101
Status
Address
Women's and Children's Hospital-Adelaide
North Adelaide 8469169, South Australia 2061327, 5006
Status
Address
Princess Margaret Hospital for Children
Perth 2063523, Western Australia 2058645, 6008
Status
Address
Perth Children's Hospital
Perth 2063523, Western Australia 2058645, 6009
Status
Address
Alberta Children's Hospital
Calgary 5913490, Alberta 5883102, T3B 6A8
Status
Address
University of Alberta Hospital
Edmonton 5946768, Alberta 5883102, T6G 2B7
Status
Address
British Columbia Children's Hospital
Vancouver 6173331, British Columbia 5909050, V6H 3V4
Status
Address
CancerCare Manitoba
Winnipeg 6183235, Manitoba 6065171, R3E 0V9
Status
Address
Janeway Child Health Centre
St. John's 6324733, Newfoundland and Labrador 6354959, A1B 3V6
Status
Address
IWK Health Centre
Halifax 6324729, Nova Scotia 6091530, B3K 6R8
Status
Address
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton 5969782, Ontario 6093943, L8N 3Z5
Status
Address
Kingston Health Sciences Centre
Kingston 5992500, Ontario 6093943, K7L 2V7
Status
Address
Children's Hospital
London 6058560, Ontario 6093943, N6A 5W9
Status
Address
Children's Hospital of Eastern Ontario
Ottawa 6094817, Ontario 6093943, K1H 8L1
Status
Address
Hospital for Sick Children
Toronto 6167865, Ontario 6093943, M5G 1X8
Status
Address
The Montreal Children's Hospital of the MUHC
Montreal 6077243, Quebec 6115047, H3H 1P3
Status
Address
Centre Hospitalier Universitaire Sainte-Justine
Montreal 6077243, Quebec 6115047, H3T 1C5
Status
Address
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke 6146143, Quebec 6115047, J1H 5N4
Status
Address
Jim Pattison Children's Hospital
Saskatoon 6141256, Saskatchewan 6141242, S7N 0W8
Status
Address
Saskatoon Cancer Centre
Saskatoon 6141256, Saskatchewan 6141242, S7N 4H4
Status
Address
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec 6325494, , G1V 4G2
Status
Address
Starship Children's Hospital
Grafton 6232401, Auckland 2193734, 1145
Status
Address
Christchurch Hospital
Christchurch 2192362, , 8011
Status
Address
San Jorge Children's Hospital
San Juan 4568127, , 00912
Status
Address
University Pediatric Hospital
San Juan 4568127, , 00926
Status
Address
King Faisal Specialist Hospital and Research Centre
Riyadh 108410, , 11211
