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Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma
Study Purpose
This randomized phase II trial studies how well pembrolizumab with or without stereotactic body radiation therapy works in treating patients with Merkel cell cancer that has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pembrolizumab with stereotactic body radiation therapy may work better in treating patients with Merkel cell cancer.
Recruitment Criteria
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Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patients must have pathologically (histologically or cytologically) proven diagnosis of MCC by local pathology review.
- - Have measurable disease based on RECIST 1.1 including at least two cancerous deposits; at least one deposit must be RECIST measurable while at least one deposit must meet criteria for SBRT; non-radiated tumor will be identified prior to randomization on the protocol.
- - Patients must have advanced or metastatic MCC defined as evidence of distant metastasis(es) on imaging.
- - Patients with locoregionally confined disease are not eligible.
- - No prior immunotherapy for advanced/metastatic MCC.
- - Patients with known or suspected central nervous system (CNS) metastases, untreated CNS metastases, or with the CNS as the only site of disease are excluded; however, subjects with controlled brain metastases will be allowed to enroll; controlled brain metastases are defined as no radiographic progression for at least 4 weeks following radiation and/or surgical treatment (or 4 weeks of observation if no intervention is clinically indicated), and off of steroids for at least 2 weeks, and no new or progressive neurological signs and symptoms.
- - Patients having received palliative radiotherapy for extracranial metastasis(es) are eligible as long as there are 2 cancerous deposits that have not received prior radiation therapy (RT) and they meet the following criteria.
- - No prior radiation therapy (> 5 Gy) to the metastasis intended to be treated with SBRT.
- - No history of the following: - Autoimmunity requiring systemic immunosuppression within 2 years.
- - Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following: - CD4 counts >= 350 mm^3.
- - Serum HIV viral load of < 25,000 IU/ml.
- - No other active malignancy that the investigator determines would interfere with the treatment and safety analysis.
- - Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown; therefore, for women of childbearing potential only, a negative (if your test schedule specifically indicates a urine or serum pregnancy test, add that information at this point) pregnancy test done =< 28 days prior to registration is required.
- - Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- - Absolute neutrophil count (ANC) >= 1,500/mm^3.
- - Platelet count >= 100,000/mm^3.
- - Hemoglobin >= 9.0 g/dl.
- - Total bilirubin =< 2.0 mg/dl.
- - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) - Systolic blood pressure (BP) =< 150 mg HG.
- - Diastolic BP =< 90 mg HG.
- - Albumin > 3 mg/dl.
- - Blood urea nitrogen (BUN) =< 30 mg/dl.
- - Creatinine =< 1.7 mg/dl.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03304639 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Jason J Luke |
| Principal Investigator Affiliation | Alliance for Clinical Trials in Oncology |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Advanced Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8, Metastatic Merkel Cell Carcinoma, Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 |
PRIMARY OBJECTIVE:
- I. To describe the progression-free survival (PFS) of stereotactic body radiation therapy (SBRT) + pembrolizumab (MK-3475) compared to pembrolizumab (MK-3475) alone in advanced/metastatic Merkel cell carcinoma (MCC) patients.
- I. To describe the PFS of SBRT + MK-3475 compared to pembrolizumab (MK-3475) alone across Response Evaluation Criteria in Solid Tumors (RECIST) measurable (including both radiated and non-radiated) cancer deposits.
- II. To describe the overall response rate of SBRT + pembrolizumab (MK-3475) compared to pembrolizumab(MK-3475) alone in both radiated and in non-radiated deposit(s).
- III. To determine the PFS at 6 months of SBRT + pembrolizumab (MK-3475) compared to pembrolizumab (MK-3475) alone across all cancerous deposits by RECIST.
- IV. To determine the rate of grade > 3-4 adverse events, by organ system, by Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0.
- V. To determine the local control of SBRT treated tumors.
- VI. To calculate delivered radiation dose using cone-beam computed tomography (CT) images collected on the radiation treatment table in the final treatment position.
- I. To test the utility of CT-based radiomics to predict radiation-induced pneumonitis and true delivered dose of SBRT based on cone beam collected imaging and diagnostic scans.
- II. Biobanking for future correlative science projects.
Arms
Active Comparator: Group I (pembrolizumab)
Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.
Experimental: Group II (pembrolizumab, SBRT)
Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients also undergo SBRT for 3 doses during cycle 1.
Interventions
Biological: - Pembrolizumab
Given IV
Radiation: - Stereotactic Body Radiation Therapy
Undergo SBRT
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Anchorage Associates in Radiation Medicine
Anchorage 5879400, Alaska 5879092, 98508
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Address
Alaska Breast Care and Surgery LLC
Anchorage 5879400, Alaska 5879092, 99508
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Address
Alaska Oncology and Hematology LLC
Anchorage 5879400, Alaska 5879092, 99508
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Address
Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092, 99508
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Address
Anchorage Oncology Centre
Anchorage 5879400, Alaska 5879092, 99508
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Address
Katmai Oncology Group
Anchorage 5879400, Alaska 5879092, 99508
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Address
Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092, 99508
Status
Address
Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752, 85719
Status
Address
University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752, 85719
Status
Address
Mercy Hospital Fort Smith
Fort Smith 4111410, Arkansas 4099753, 72903
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Address
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs 4115412, Arkansas 4099753, 71913
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Address
PCR Oncology
Arroyo Grande 5324802, California 5332921, 93420
Status
Address
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank 5331835, California 5332921, 91505
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Address
Penrose-Saint Francis Healthcare
Colorado Springs 5417598, Colorado 5417618, 80907
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Address
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618, 80907
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Address
AdventHealth Porter
Denver 5419384, Colorado 5417618, 80210
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Address
Saint Anthony Hospital
Lakewood 5427946, Colorado 5417618, 80228
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Address
AdventHealth Littleton
Littleton 5429032, Colorado 5417618, 80122
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Longmont United Hospital
Longmont 5579276, Colorado 5417618, 80501
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Address
AdventHealth Parker
Parker 5434006, Colorado 5417618, 80138
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Address
Saint Mary Corwin Medical Center
Pueblo 5435464, Colorado 5417618, 81004
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Address
Rocky Mountain Cancer Centers-Thornton
Thornton 5441492, Colorado 5417618, 80260
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Address
Smilow Cancer Center/Yale-New Haven Hospital
New Haven 4839366, Connecticut 4831725, 06510
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Address
Yale University
New Haven 4839366, Connecticut 4831725, 06520
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Address
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751, 33180
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Address
Holy Cross Hospital
Fort Lauderdale 4155966, Florida 4155751, 33308
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Address
Mount Sinai Medical Center
Miami Beach 4164143, Florida 4155751, 33140
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Address
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000, 31405
Status
Address
Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512, 83706
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Address
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512, 83712
Status
Address
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell 5587698, Idaho 5596512, 83605
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Address
Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512, 83814
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Address
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512, 83619
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Address
Idaho Urologic Institute-Meridian
Meridian 5600685, Idaho 5596512, 83642
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Address
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512, 83642
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Address
Saint Alphonsus Cancer Care Center-Nampa
Nampa 5601933, Idaho 5596512, 83687
Status
Address
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512, 83687
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Address
Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512, 83854
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Address
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512, 83864
Status
Address
Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512, 83301
Status
Address
Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861, 60504
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Address
Northwestern University
Chicago 4887398, Illinois 4896861, 60611
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Address
Rush University Medical Center
Chicago 4887398, Illinois 4896861, 60612
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Address
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861, 60637
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Address
Carle at The Riverfront
Danville 4889426, Illinois 4896861, 61832
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Address
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861, 62401
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Address
Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861, 60045
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Address
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861, 61938
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Address
SSM Health Good Samaritan
Mount Vernon 4245152, Illinois 4896861, 62864
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Address
UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861, 60451
Status
Address
University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861, 60462
Status
Address
Carle Cancer Center
Urbana 4914570, Illinois 4896861, 61801
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Address
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861, 61801
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Address
Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861, 60560
Status
Address
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis 4259418, Indiana 4921868, 46202
Status
Address
Sidney and Lois Eskenazi Hospital
Indianapolis 4259418, Indiana 4921868, 46202
Status
Address
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182, 50325
Status
Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182, 50325
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Address
Greater Regional Medical Center
Creston 4853078, Iowa 4862182, 50801
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Address
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182, 50309
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Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182, 50309
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Address
Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182, 50314
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Address
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182, 50314
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Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182, 50314
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Address
Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182, 50316
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Address
Methodist West Hospital
West Des Moines 4881346, Iowa 4862182, 50266-7700
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Address
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182, 50266
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Address
Central Care Cancer Center - Garden City
Garden City 5445439, Kansas 4273857, 67846
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Address
Central Care Cancer Center - Great Bend
Great Bend 4272340, Kansas 4273857, 67530
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Address
University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857, 66160
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Address
Lawrence Memorial Hospital
Lawrence 4274277, Kansas 4273857, 66044
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Address
Kansas Institute of Medicine Cancer and Blood Center
Lenexa 4274356, Kansas 4273857, 66219
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Address
Minimally Invasive Surgery Hospital
Lenexa 4274356, Kansas 4273857, 66219
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Address
Menorah Medical Center
Overland Park 4276873, Kansas 4273857, 66209
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Address
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857, 66210
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Address
Saint Luke's South Hospital
Overland Park 4276873, Kansas 4273857, 66213
Status
Address
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857, 66205
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita 4281730, Kansas 4273857, 67208
Status
Address
Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857, 67214
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Address
Cancer Center of Kansas - Wichita
Wichita 4281730, Kansas 4273857, 67214
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Address
Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925, 40504
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Address
Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925, 40509
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Address
Jewish Hospital
Louisville 4299276, Kentucky 6254925, 40202
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Address
UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925, 40245
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Address
Ochsner Health Center-Summa
Baton Rouge 4315588, Louisiana 4331987, 70809
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Address
Medical Center of Baton Rouge
Baton Rouge 4315588, Louisiana 4331987, 70816
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Address
Ochsner High Grove
Baton Rouge 4315588, Louisiana 4331987, 70836
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Address
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987, 70121
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Address
Bronson Battle Creek
Battle Creek 4985153, Michigan 5001836, 49017
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Address
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836, 49503
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Address
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836, 49007
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Address
Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836, 49048
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Address
Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836, 49444
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Address
Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836, 49120
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Address
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores 5004005, Michigan 5001836, 49444
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Address
Corewell Health Reed City Hospital
Reed City 5006946, Michigan 5001836, 49677
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Address
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836, 49085
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Address
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836, 49085
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Address
Munson Medical Center
Traverse City 5012495, Michigan 5001836, 49684
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Address
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836, 49519
Status
Address
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779, 56601
Status
Address
Fairview Ridges Hospital
Burnsville 5019767, Minnesota 5037779, 55337
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Address
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779, 55433
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Address
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779, 55435
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Address
Unity Hospital
Fridley 5027482, Minnesota 5037779, 55432
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Address
Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779, 55369
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779, 55109
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Address
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779, 55109
Status
Address
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779, 55407
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Address
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779, 55415
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Address
Health Partners Inc
Minneapolis 5037649, Minnesota 5037779, 55454
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Address
Monticello Cancer Center
Monticello 5038045, Minnesota 5037779, 55362
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Address
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779, 55422
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Address
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779, 55905
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Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779, 55416
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Address
Regions Hospital
Saint Paul 5045360, Minnesota 5037779, 55101
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Address
United Hospital
Saint Paul 5045360, Minnesota 5037779, 55102
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Address
Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779, 55379
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Address
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779, 55082
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Address
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779, 55387
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Address
Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779, 55125
Status
Address
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin 4375663, Missouri 4398678, 63011
Status
Address
Central Care Cancer Center - Bolivar
Bolivar 4377835, Missouri 4398678, 65613
Status
Address
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678, 63376
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Address
Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678, 63141
Status
Address
Centerpoint Medical Center LLC
Independence 4391812, Missouri 4398678, 64057
Status
Address
Freeman Health System
Joplin 4392768, Missouri 4398678, 64804
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Address
Saint Luke's Hospital of Kansas City
Kansas City 4393217, Missouri 4398678, 64111
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Address
Research Medical Center
Kansas City 4393217, Missouri 4398678, 64132
Status
Address
Saint Luke's East - Lee's Summit
Lee's Summit 4394870, Missouri 4398678, 64086
Status
Address
Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678, 65401
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Address
Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678, 65401
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Address
Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678, 64506
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Address
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678, 65804
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Address
CoxHealth South Hospital
Springfield 4409896, Missouri 4398678, 65807
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Address
Washington University School of Medicine
St Louis 4407066, Missouri 4398678, 63110
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Address
Mercy Hospital South
St Louis 4407066, Missouri 4398678, 63128
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Address
Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678, 63129
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Address
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678, 63141
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Address
Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009, 59711
Status
Address
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009, 59101
Status
Address
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009, 59715
Status
Address
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009, 59405
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Address
Great Falls Clinic
Great Falls 5655240, Montana 5667009, 59405
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Address
Saint Peter's Community Hospital
Helena 5656882, Montana 5667009, 59601
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Address
Logan Health Medical Center
Kalispell 5660340, Montana 5667009, 59901
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Address
Community Medical Center
Missoula 5666639, Montana 5667009, 59804
Status
Address
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island 5069297, Nebraska 5073708, 68803
Status
Address
CHI Health Good Samaritan
Kearney 5071348, Nebraska 5073708, 68847
Status
Address
Alegent Health Immanuel Medical Center
Omaha 5074472, Nebraska 5073708, 68122
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Address
Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708, 68124
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Address
Alegent Health Lakeside Hospital
Omaha 5074472, Nebraska 5073708, 68130
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Address
Creighton University Medical Center
Omaha 5074472, Nebraska 5073708, 68131
Status
Address
Comprehensive Cancer Centers of Nevada - Henderson
Henderson 5505411, Nevada 5509151, 89052
Status
Address
OptumCare Cancer Care at Seven Hills
Henderson 5505411, Nevada 5509151, 89052
Status
Address
OptumCare Cancer Care at Charleston
Las Vegas 5506956, Nevada 5509151, 89102
Status
Address
Radiation Oncology Centers of Nevada Central
Las Vegas 5506956, Nevada 5509151, 89106
Status
Address
GenesisCare USA - Las Vegas
Las Vegas 5506956, Nevada 5509151, 89109
Status
Address
Radiation Oncology Centers of Nevada Southeast
Las Vegas 5506956, Nevada 5509151, 89119
Status
Address
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas 5506956, Nevada 5509151, 89128
Status
Address
OptumCare Cancer Care at MountainView
Las Vegas 5506956, Nevada 5509151, 89128
Status
Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151, 89135
Status
Address
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas 5506956, Nevada 5509151, 89144
Status
Address
Comprehensive Cancer Centers of Nevada
Las Vegas 5506956, Nevada 5509151, 89148
Status
Address
OptumCare Cancer Care at Fort Apache
Las Vegas 5506956, Nevada 5509151, 89148
Status
Address
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas 5506956, Nevada 5509151, 89169
Status
Address
Renown Regional Medical Center
Reno 5511077, Nevada 5509151, 89502
Status
Address
Saint Mary's Regional Medical Center
Reno 5511077, Nevada 5509151, 89503
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Address
Radiation Oncology Associates
Reno 5511077, Nevada 5509151, 89509
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Address
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760, 07601
Status
Address
Duke University Medical Center
Durham 4464368, North Carolina 4482348, 27710
Status
Address
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763, 58501
Status
Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
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Address
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Address
Strecker Cancer Center-Belpre
Belpre 4506187, Ohio 5165418, 45714
Status
Address
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418, 45601
Status
Address
Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418, 45220
Status
Address
Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418, 45242
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Address
MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418, 44109
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Address
Mount Carmel East Hospital
Columbus 4509177, Ohio 5165418, 43213
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Address
Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418, 43214
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Address
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418, 43214
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Address
Grant Medical Center
Columbus 4509177, Ohio 5165418, 43215
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Address
The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418, 43219
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Address
Mount Carmel Health Center West
Columbus 4509177, Ohio 5165418, 43222
Status
Address
Doctors Hospital
Columbus 4509177, Ohio 5165418, 43228
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Delaware Radiation Oncology
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418, 43015
Status
Address
Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418, 43016
Status
Address
Fairfield Medical Center
Lancaster 4516233, Ohio 5165418, 43130
Status
Address
OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418, 44903
Status
Address
Marietta Memorial Hospital
Marietta 4517586, Ohio 5165418, 45750
Status
Address
OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418, 43302
Status
Address
Knox Community Hospital
Mount Vernon 5163799, Ohio 5165418, 43050
Status
Address
Licking Memorial Hospital
Newark 5164466, Ohio 5165418, 43055
Status
Address
Newark Radiation Oncology
Newark 5164466, Ohio 5165418, 43055
Status
Address
Southern Ohio Medical Center
Portsmouth 4521816, Ohio 5165418, 45662
Status
Address
Saint Ann's Hospital
Westerville 5176472, Ohio 5165418, 43081
Status
Address
Genesis Healthcare System Cancer Care Center
Zanesville 4528923, Ohio 5165418, 43701
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Address
Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379, 73120
Status
Address
Saint Charles Health System
Bend 5713587, Oregon 5744337, 97701
Status
Address
Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337, 97015
Status
Address
Bay Area Hospital
Coos Bay 5720495, Oregon 5744337, 97420
Status
Address
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337, 97132
Status
Address
Providence Portland Medical Center
Portland 5746545, Oregon 5744337, 97213
Status
Address
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337, 97225
Status
Address
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927, 17822
Status
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927, 17837
Status
Address
Lewistown Hospital
Lewistown 5197850, Pennsylvania 6254927, 17044
Status
Address
University of Pennsylvania/Abramson Cancer Center
Philadelphia 4560349, Pennsylvania 6254927, 19104
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927, 18711
Status
Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Address
Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040, 29341
Status
Address
Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040, 29651
Status
Address
Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040, 29303
Status
Address
SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040, 29379
Status
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223, 57104
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Address
Memorial Hospital
Chattanooga 4612862, Tennessee 4662168, 37404
Status
Address
Saint Joseph Regional Cancer Center
Bryan 4677008, Texas 4736286, 77802
Status
Address
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Address
Providence Regional Cancer System-Aberdeen
Aberdeen 5785243, Washington 5815135, 98520
Status
Address
Overlake Medical Center
Bellevue 5786882, Washington 5815135, 98004
Status
Address
PeaceHealth Saint Joseph Medical Center
Bellingham 5786899, Washington 5815135, 98225
Status
Address
Highline Medical Center-Main Campus
Burien 5788516, Washington 5815135, 98166
Status
Address
Providence Regional Cancer System-Centralia
Centralia 5789683, Washington 5815135, 98531
Status
Address
Providence Regional Cancer Partnership
Everett 5793933, Washington 5815135, 98201
Status
Address
Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135, 98029
Status
Address
Kadlec Clinic Hematology and Oncology
Kennewick 5799610, Washington 5815135, 99336
Status
Address
Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135, 98503
Status
Address
PeaceHealth Saint John Medical Center
Longview 5801617, Washington 5815135, 98632
Status
Address
Valley Medical Center
Renton 5808189, Washington 5815135, 98055
Status
Address
Swedish Medical Center-Ballard Campus
Seattle 5809844, Washington 5815135, 98107
Status
Address
Kaiser Permanente Washington
Seattle 5809844, Washington 5815135, 98112
Status
Address
Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135, 98122
Status
Address
PeaceHealth United General Medical Center
Sedro-Woolley 5809902, Washington 5815135, 98284
Status
Address
Saint Michael Cancer Center
Silverdale 5810490, Washington 5815135, 98383
Status
Address
Northwest Medical Specialties PLLC
Tacoma 5812944, Washington 5815135, 98405
Status
Address
PeaceHealth Southwest Medical Center
Vancouver 5814616, Washington 5815135, 98664
Status
Address
Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135, 99362
Status
Address
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468, 54701
Status
Address
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468, 54449
Status
Address
Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468, 54548
Status
Address
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468, 54017
Status
Address
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468, 54868
Status
Address
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468, 54482
Status
Address
Marshfield Clinic-Wausau Center
Wausau 5278120, Wisconsin 5279468, 54401
Status
Address
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468, 54476
Status
Address
Billings Clinic-Cody
Cody 5821593, Wyoming 5843591, 82414
