Get Involved
Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma
Study Purpose
This randomized phase II trial studies how well pembrolizumab with or without stereotactic body radiation therapy works in treating patients with Merkel cell cancer that has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pembrolizumab with stereotactic body radiation therapy may work better in treating patients with Merkel cell cancer.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Patients must have pathologically (histologically or cytologically) proven diagnosis of MCC by local pathology review.
- - Have measurable disease based on RECIST 1.1 including at least two cancerous deposits; at least one deposit must be RECIST measurable while at least one deposit must meet criteria for SBRT; non-radiated tumor will be identified prior to randomization on the protocol.
- - Patients must have advanced or metastatic MCC defined as evidence of distant metastasis(es) on imaging.
- - Patients with locoregionally confined disease are not eligible.
- - No prior immunotherapy for advanced/metastatic MCC.
- - Patients with known or suspected central nervous system (CNS) metastases, untreated CNS metastases, or with the CNS as the only site of disease are excluded; however, subjects with controlled brain metastases will be allowed to enroll; controlled brain metastases are defined as no radiographic progression for at least 4 weeks following radiation and/or surgical treatment (or 4 weeks of observation if no intervention is clinically indicated), and off of steroids for at least 2 weeks, and no new or progressive neurological signs and symptoms.
- - Patients having received palliative radiotherapy for extracranial metastasis(es) are eligible as long as there are 2 cancerous deposits that have not received prior radiation therapy (RT) and they meet the following criteria.
- - No prior radiation therapy (> 5 Gy) to the metastasis intended to be treated with SBRT.
- - No history of the following: - Autoimmunity requiring systemic immunosuppression within 2 years.
- - Patients known to be human immunodeficiency virus (HIV) positive are eligible if they meet the following: - CD4 counts >= 350 mm^3.
- - Serum HIV viral load of < 25,000 IU/ml.
- - No other active malignancy that the investigator determines would interfere with the treatment and safety analysis.
- - Not pregnant and not nursing, because this study involves an investigational agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown; therefore, for women of childbearing potential only, a negative (if your test schedule specifically indicates a urine or serum pregnancy test, add that information at this point) pregnancy test done =< 28 days prior to registration is required.
- - Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- - Absolute neutrophil count (ANC) >= 1,500/mm^3.
- - Platelet count >= 100,000/mm^3.
- - Hemoglobin >= 9.0 g/dl.
- - Total bilirubin =< 2.0 mg/dl.
- - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3.0 x upper limit of normal (ULN) - Systolic blood pressure (BP) =< 150 mg HG.
- - Diastolic BP =< 90 mg HG.
- - Albumin > 3 mg/dl.
- - Blood urea nitrogen (BUN) =< 30 mg/dl.
- - Creatinine =< 1.7 mg/dl.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT03304639 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Jason J Luke |
| Principal Investigator Affiliation | Alliance for Clinical Trials in Oncology |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH |
| Overall Status | Active, not recruiting |
| Countries | United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Advanced Merkel Cell Carcinoma, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8, Metastatic Merkel Cell Carcinoma, Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8, Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 |
PRIMARY OBJECTIVE:
- I. To describe the progression-free survival (PFS) of stereotactic body radiation therapy (SBRT) + pembrolizumab (MK-3475) compared to pembrolizumab (MK-3475) alone in advanced/metastatic Merkel cell carcinoma (MCC) patients.
- I. To describe the PFS of SBRT + MK-3475 compared to pembrolizumab (MK-3475) alone across Response Evaluation Criteria in Solid Tumors (RECIST) measurable (including both radiated and non-radiated) cancer deposits.
- II. To describe the overall response rate of SBRT + pembrolizumab (MK-3475) compared to pembrolizumab(MK-3475) alone in both radiated and in non-radiated deposit(s).
- III. To determine the PFS at 6 months of SBRT + pembrolizumab (MK-3475) compared to pembrolizumab (MK-3475) alone across all cancerous deposits by RECIST.
- IV. To determine the rate of grade > 3-4 adverse events, by organ system, by Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0.
- V. To determine the local control of SBRT treated tumors.
- VI. To calculate delivered radiation dose using cone-beam computed tomography (CT) images collected on the radiation treatment table in the final treatment position.
- I. To test the utility of CT-based radiomics to predict radiation-induced pneumonitis and true delivered dose of SBRT based on cone beam collected imaging and diagnostic scans.
- II. Biobanking for future correlative science projects.
Arms
Active Comparator: Group I (pembrolizumab)
Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity.
Experimental: Group II (pembrolizumab, SBRT)
Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients also undergo SBRT for 3 doses during cycle 1.
Interventions
Biological: - Pembrolizumab
Given IV
Radiation: - Stereotactic Body Radiation Therapy
Undergo SBRT
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
Status
Address
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
Status
Address
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
Status
Address
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
Status
Address
Anchorage Oncology Centre
Anchorage, Alaska, 99508
Status
Address
Katmai Oncology Group
Anchorage, Alaska, 99508
Status
Address
Providence Alaska Medical Center
Anchorage, Alaska, 99508
Status
Address
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
Status
Address
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
Status
Address
Mercy Hospital Fort Smith
Fort Smith, Arkansas, 72903
Status
Address
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas, 71913
Status
Address
PCR Oncology
Arroyo Grande, California, 93420
Status
Address
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
Status
Address
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
Status
Address
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
Status
Address
AdventHealth Porter
Denver, Colorado, 80210
Status
Address
Saint Anthony Hospital
Lakewood, Colorado, 80228
Status
Address
AdventHealth Littleton
Littleton, Colorado, 80122
Status
Address
Longmont United Hospital
Longmont, Colorado, 80501
Status
Address
AdventHealth Parker
Parker, Colorado, 80138
Status
Address
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
Status
Address
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado, 80260
Status
Address
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510
Status
Address
Yale University
New Haven, Connecticut, 06520
Status
Address
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
Status
Address
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
Status
Address
Mount Sinai Medical Center
Miami Beach, Florida, 33140
Status
Address
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
Status
Address
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
Status
Address
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Status
Address
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
Status
Address
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
Status
Address
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
Status
Address
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
Status
Address
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
Status
Address
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
Status
Address
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
Status
Address
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
Status
Address
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
Status
Address
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
Status
Address
Rush - Copley Medical Center
Aurora, Illinois, 60504
Status
Address
Northwestern University
Chicago, Illinois, 60611
Status
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Address
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Status
Address
Carle at The Riverfront
Danville, Illinois, 61832
Status
Address
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Status
Address
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
Status
Address
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
Status
Address
SSM Health Good Samaritan
Mount Vernon, Illinois, 62864
Status
Address
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
Status
Address
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
Status
Address
Carle Cancer Center
Urbana, Illinois, 61801
Status
Address
The Carle Foundation Hospital
Urbana, Illinois, 61801
Status
Address
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
Status
Address
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
Status
Address
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana, 46202
Status
Address
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
Status
Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
Status
Address
Greater Regional Medical Center
Creston, Iowa, 50801
Status
Address
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
Status
Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
Status
Address
Broadlawns Medical Center
Des Moines, Iowa, 50314
Status
Address
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
Status
Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
Status
Address
Iowa Lutheran Hospital
Des Moines, Iowa, 50316
Status
Address
Methodist West Hospital
West Des Moines, Iowa, 50266-7700
Status
Address
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
Status
Address
Central Care Cancer Center - Garden City
Garden City, Kansas, 67846
Status
Address
Central Care Cancer Center - Great Bend
Great Bend, Kansas, 67530
Status
Address
University of Kansas Cancer Center
Kansas City, Kansas, 66160
Status
Address
Lawrence Memorial Hospital
Lawrence, Kansas, 66044
Status
Address
Kansas Institute of Medicine Cancer and Blood Center
Lenexa, Kansas, 66219
Status
Address
Minimally Invasive Surgery Hospital
Lenexa, Kansas, 66219
Status
Address
Menorah Medical Center
Overland Park, Kansas, 66209
Status
Address
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210
Status
Address
Saint Luke's South Hospital
Overland Park, Kansas, 66213
Status
Address
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
Status
Address
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas, 67208
Status
Address
Ascension Via Christi Hospitals Wichita
Wichita, Kansas, 67214
Status
Address
Cancer Center of Kansas - Wichita
Wichita, Kansas, 67214
Status
Address
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
Status
Address
Saint Joseph Hospital East
Lexington, Kentucky, 40509
Status
Address
Jewish Hospital
Louisville, Kentucky, 40202
Status
Address
UofL Health Medical Center Northeast
Louisville, Kentucky, 40245
Status
Address
Ochsner Health Center-Summa
Baton Rouge, Louisiana, 70809
Status
Address
Medical Center of Baton Rouge
Baton Rouge, Louisiana, 70816
Status
Address
Ochsner High Grove
Baton Rouge, Louisiana, 70836
Status
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Status
Address
Bronson Battle Creek
Battle Creek, Michigan, 49017
Status
Address
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
Status
Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Status
Address
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Status
Address
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
Status
Address
Ascension Borgess Hospital
Kalamazoo, Michigan, 49048
Status
Address
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
Status
Address
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120
Status
Address
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, 49444
Status
Address
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
Status
Address
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
Status
Address
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
Status
Address
Munson Medical Center
Traverse City, Michigan, 49684
Status
Address
University of Michigan Health - West
Wyoming, Michigan, 49519
Status
Address
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Status
Address
Fairview Ridges Hospital
Burnsville, Minnesota, 55337
Status
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Status
Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
Status
Address
Unity Hospital
Fridley, Minnesota, 55432
Status
Address
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
Status
Address
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
Status
Address
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
Status
Address
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
Status
Address
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
Status
Address
Health Partners Inc
Minneapolis, Minnesota, 55454
Status
Address
Monticello Cancer Center
Monticello, Minnesota, 55362
Status
Address
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
Status
Address
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
Status
Address
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
Status
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Status
Address
United Hospital
Saint Paul, Minnesota, 55102
Status
Address
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
Status
Address
Lakeview Hospital
Stillwater, Minnesota, 55082
Status
Address
Ridgeview Medical Center
Waconia, Minnesota, 55387
Status
Address
Rice Memorial Hospital
Willmar, Minnesota, 56201
Status
Address
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
Status
Address
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri, 63011
Status
Address
Central Care Cancer Center - Bolivar
Bolivar, Missouri, 65613
Status
Address
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri, 63141
Status
Address
Centerpoint Medical Center LLC
Independence, Missouri, 64057
Status
Address
Freeman Health System
Joplin, Missouri, 64804
Status
Address
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, 64111
Status
Address
Research Medical Center
Kansas City, Missouri, 64132
Status
Address
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri, 64086
Status
Address
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri, 65401
Status
Address
Phelps Health Delbert Day Cancer Institute
Rolla, Missouri, 65401
Status
Address
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506
Status
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
Status
Address
Mercy Hospital South
Saint Louis, Missouri, 63128
Status
Address
Siteman Cancer Center-South County
Saint Louis, Missouri, 63129
Status
Address
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
Status
Address
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri, 63376
Status
Address
Mercy Hospital Springfield
Springfield, Missouri, 65804
Status
Address
CoxHealth South Hospital
Springfield, Missouri, 65807
Status
Address
Community Hospital of Anaconda
Anaconda, Montana, 59711
Status
Address
Billings Clinic Cancer Center
Billings, Montana, 59101
Status
Address
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
Status
Address
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
Status
Address
Great Falls Clinic
Great Falls, Montana, 59405
Status
Address
Saint Peter's Community Hospital
Helena, Montana, 59601
Status
Address
Logan Health Medical Center
Kalispell, Montana, 59901
Status
Address
Community Medical Center
Missoula, Montana, 59804
Status
Address
Nebraska Cancer Specialists/Oncology Hematology West PC
Grand Island, Nebraska, 68803
Status
Address
CHI Health Good Samaritan
Kearney, Nebraska, 68847
Status
Address
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
Status
Address
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
Status
Address
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
Status
Address
Creighton University Medical Center
Omaha, Nebraska, 68131
Status
Address
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada, 89052
Status
Address
OptumCare Cancer Care at Seven Hills
Henderson, Nevada, 89052
Status
Address
OptumCare Cancer Care at Charleston
Las Vegas, Nevada, 89102
Status
Address
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada, 89106
Status
Address
GenesisCare USA - Las Vegas
Las Vegas, Nevada, 89109
Status
Address
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada, 89119
Status
Address
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada, 89128
Status
Address
OptumCare Cancer Care at MountainView
Las Vegas, Nevada, 89128
Status
Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
Status
Address
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada, 89144
Status
Address
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada, 89148
Status
Address
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada, 89148
Status
Address
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada, 89169
Status
Address
Renown Regional Medical Center
Reno, Nevada, 89502
Status
Address
Saint Mary's Regional Medical Center
Reno, Nevada, 89503
Status
Address
Radiation Oncology Associates
Reno, Nevada, 89509
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Duke University Medical Center
Durham, North Carolina, 27710
Status
Address
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Status
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Address
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Status
Address
Strecker Cancer Center-Belpre
Belpre, Ohio, 45714
Status
Address
Adena Regional Medical Center
Chillicothe, Ohio, 45601
Status
Address
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
Status
Address
Bethesda North Hospital
Cincinnati, Ohio, 45242
Status
Address
MetroHealth Medical Center
Cleveland, Ohio, 44109
Status
Address
Mount Carmel East Hospital
Columbus, Ohio, 43213
Status
Address
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
Status
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Address
Grant Medical Center
Columbus, Ohio, 43215
Status
Address
The Mark H Zangmeister Center
Columbus, Ohio, 43219
Status
Address
Mount Carmel Health Center West
Columbus, Ohio, 43222
Status
Address
Doctors Hospital
Columbus, Ohio, 43228
Status
Address
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
Status
Address
Delaware Radiation Oncology
Delaware, Ohio, 43015
Status
Address
Grady Memorial Hospital
Delaware, Ohio, 43015
Status
Address
Dublin Methodist Hospital
Dublin, Ohio, 43016
Status
Address
Fairfield Medical Center
Lancaster, Ohio, 43130
Status
Address
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
Status
Address
Marietta Memorial Hospital
Marietta, Ohio, 45750
Status
Address
OhioHealth Marion General Hospital
Marion, Ohio, 43302
Status
Address
Knox Community Hospital
Mount Vernon, Ohio, 43050
Status
Address
Licking Memorial Hospital
Newark, Ohio, 43055
Status
Address
Newark Radiation Oncology
Newark, Ohio, 43055
Status
Address
Southern Ohio Medical Center
Portsmouth, Ohio, 45662
Status
Address
Saint Ann's Hospital
Westerville, Ohio, 43081
Status
Address
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio, 43701
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Address
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
Status
Address
Saint Charles Health System
Bend, Oregon, 97701
Status
Address
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
Status
Address
Bay Area Hospital
Coos Bay, Oregon, 97420
Status
Address
Providence Newberg Medical Center
Newberg, Oregon, 97132
Status
Address
Providence Portland Medical Center
Portland, Oregon, 97213
Status
Address
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Status
Address
Lewistown Hospital
Lewistown, Pennsylvania, 17044
Status
Address
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104
Status
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Address
Medical University of South Carolina
Charleston, South Carolina, 29425
Status
Address
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Status
Address
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
Status
Address
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
Status
Address
SMC Center for Hematology Oncology Union
Union, South Carolina, 29379
Status
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Address
Memorial Hospital
Chattanooga, Tennessee, 37404
Status
Address
Saint Joseph Regional Cancer Center
Bryan, Texas, 77802
Status
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
Status
Address
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
Status
Address
Overlake Medical Center
Bellevue, Washington, 98004
Status
Address
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
Status
Address
Highline Medical Center-Main Campus
Burien, Washington, 98166
Status
Address
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
Status
Address
Providence Regional Cancer Partnership
Everett, Washington, 98201
Status
Address
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
Status
Address
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
Status
Address
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
Status
Address
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
Status
Address
Valley Medical Center
Renton, Washington, 98055
Status
Address
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
Status
Address
Kaiser Permanente Washington
Seattle, Washington, 98112
Status
Address
Swedish Medical Center-First Hill
Seattle, Washington, 98122
Status
Address
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
Status
Address
Saint Michael Cancer Center
Silverdale, Washington, 98383
Status
Address
Northwest Medical Specialties PLLC
Tacoma, Washington, 98405
Status
Address
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
Status
Address
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
Status
Address
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
Status
Address
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Status
Address
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
Status
Address
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
Status
Address
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
Status
Address
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
Status
Address
Marshfield Clinic-Wausau Center
Wausau, Wisconsin, 54401
Status
Address
Diagnostic and Treatment Center
Weston, Wisconsin, 54476
Status
Address
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
Status
Address
Billings Clinic-Cody
Cody, Wyoming, 82414
