Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Get Involved

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Study Purpose

A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors (phase 1). Neuroblastoma tumor specific cohort to further evaluate antitumor activity of palbociclib in combination with topotecan and cyclophosphamide in children, adolescents, and young adults with recurrent or refractory neuroblastoma. Phase 2 to learn about the efficacy of palbociclib in combination with irinotecan and temozolomide when compared with irinotecan and temozolomide alone in the treatment of children, adolescents, and young adults with recurrent or refractory Ewing sarcoma (EWS).

Recruitment Criteria

Accepts Healthy Volunteers Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms	No
Study Type An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies.	Interventional
Eligible Ages	2 Years - 20 Years
Gender	All

More Inclusion & Exclusion Criteria

Inclusion: 1. Histologically confirmed relapsed or refractory solid tumor as follows:

- For dose escalation and dose determination parts: Histologically confirmed relapsed or refractory solid tumor (including CNS tumors but not lymphomas).

Patients with Diffuse Intrinsic Pontine Glioma do not require histological only radiographic confirmed relapse to enroll.

- For dose expansion and tumor specific cohorts: Histologically confirmed relapsed or refractory solid tumor including but not limited to EWS, rhabdoid tumor, rhabdomyosarcoma, neuroblastoma, and medulloblastoma.

Patients with Diffuse Intrinsic Pontine Glioma do not require histological only radiographic confirmed relapse to enroll. EWS is not eligible for TOPO and CTX tumor-specific cohorts.

- For randomized Phase 2 part: Histologically confirmed Ewing sarcoma at diagnosis or at relapse, with presence of EWSR1-ETS or FUS-ETS rearrangement.

Histopathology confirmation of both EWSR1-ETS or FUS-ETS rearrangement partners is required OR availability of formalin fixed paraffin embedded (FFPE) tumor tissue sample for central testing. Patient must have relapsed or have refractory disease and at least evaluable disease in at least one site other than bone marrow that can be followed by imaging. 2. Age ≥2 and <21 years at the time of study entry. 3. Lansky performance status ≥50% for patients ≤16 years of age, or Eastern Cooperative Oncology Group (ECOG) 0, 1 or 2 for patients >16 years of age. 4. Adequate bone marrow function.

- Absolute neutrophil count ≥1000/mm3; - Platelet count ≥75,000/mm3 (transfusion independent, no platelet transfusion in past 7 days prior study entry); - Hemoglobin ≥8.5 g/dL (transfusion allowed).

5. Adequate renal function: Serum creatinine level based on age/gender must within protocol specified limits. 6. Adequate liver function, including:

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × upper limit of normal (ULN) or ≤5 × ULN for age, if attributable to disease involvement of the liver; - Total bilirubin ≤1.5 × ULN for age, unless the patient has documented Gilbert's syndrome.

Patients with documented Gilbert's syndrome are eligible if direct bilirubin is within normal ranges (≤ULN). 7. Patients enrolled to Phase 1 portion of the study and tumor specific cohorts must have measurable disease as defined by RECIST version 1.1 or modified RANO criteria for CNS disease or at least evaluable disease by INRC for neuroblastoma. The eligible patients with neuroblastoma must have at least one of the following at the time of study entry:

- Measurable tumor by CT or MRI that is avid on MIBG scan or demonstrates increased FDG uptake on PET scan; - Avid lesion on MIBG scan with positive uptake at a minimum of one site; - For disease that is not avid by MIBG-scan, at least one lesion that demonstrates increased FDG uptake on PET scan AND viable neuroblastoma confirmed by current or prior biopsy; - bone marrow involvement with more than 5% neuroblastoma cells in at least one sample from bilateral bone marrow biopsies; - In non MIBG-avid refractory soft tissue disease that does not demonstrate increased FDG uptake; lesion biopsy is required to document the presence of viable neuroblastoma, unless patient has a new soft tissue lesion (radiographic evidence of disease progression).

Patients with EWS enrolled to Phase 2 portion of the study are eligible with evaluable disease (eg, bone only disease with no soft tissue component). 8. Recovered to CTCAE Grade ≤1, or to baseline, from any non-hematological acute toxicities of prior surgery, chemotherapy, immunotherapy, radiotherapy, differentiation therapy or biologic therapy, with the exception of alopecia. 9. Serum/urine pregnancy test (for all girls ≥8 years of age) negative at screening and at the baseline visit. Exclusion: 1. Phase 1 and tumor specific cohorts: For palbociclib with IRN and TMZ combination, prior treatment with a CDK4/6 inhibitor or progression while on treatment with an IRN-containing regimen that includes TMZ. Patients who have received the combination of IRN and TMZ and did not progress while on these medications are eligible. For patients enrolling in the palbociclib with TOPO and CTX combination, prior treatment with a CDK4/6 inhibitor or progression while on treatment with a TOPO-containing regimen that includes CTX. Patients who have received the combination of TOPO and CTX and did not progress while on these medications are eligible. Phase 2 portion: prior treatment with a CDK4/6 inhibitor or progression while on treatment with an IRN-containing or TMZ-containing regimen. Patients who have received IRN and/or TMZ and did not progress while on these medications are eligible. 2. Prior intolerability to IRN and/or TMZ plus/minus palbociclib with IRN and TMZ combination and prior intolerability to TOPO and/or CTX for TOPO and CTX combination. For patients enrolled in the UK, any contraindication for IRN and/or TMZ treatment, as per the local SmPC. 3. Use of strong cytochrome P450 (CYP) 3A inhibitors or inducers within 12 days of study entry. Patients who are receiving strong uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) inhibitors within 12 days of Cycle 1 Day 1 (C1D1) are not eligible for the palbociclib with IRN and TMZ combination. Patients who are receiving strong UGT1A1 inhibitors within 12 days of C1D1 are eligible for the palbociclib with TOPO and CTX combination (See Section 5.7.1 for list of products.) 4. Systemic anti cancer therapy within 2 weeks prior to study entry and 6 weeks for nitrosoureas. 5. Prior irradiation to >50% of the bone marrow (see Appendix 9). 6. Participation in other studies involving investigational drug(s) within 2 weeks or 5 half lives, whichever is longer, prior to study entry. 7. Major surgery within 4 weeks prior to study entry. Surgical biopsies or central line placement are not considered major surgeries. 8. For IRN and TMZ with/without palbociclib combinations: known or suspected hypersensitivity to palbociclib, dacarbazine, IRN and/or TMZ. For combination of palbociclib with TOPO and CTX: known or suspected hypersensitivity to palbociclib, TOPO and/or CTX. 9. Patients with known symptomatic brain tumors or brain metastases and require steroids, unless they have been on a stable or on a decreasing steroid dose for >14 days. 10. Patients with previously diagnosed brain metastases are eligible if they have completed their prior treatment and have recovered from the acute effects of radiation therapy or surgery prior to study entry for these metastases for at least 14 days post radiation and 4 weeks post-surgery and are neurologically stable. 11. Hereditary bone marrow failure disorder. 12. QTc >470 msec. 13. History of clinically significant or uncontrolled cardiac disease, including:

- History of or active congestive heart failure; if patient had congestive heart failure resolve and >1 year from resolution, patient will be considered eligible; - Clinically significant ventricular arrhythmia (such as ventricular tachycardia, ventricular fibrillation or Torsades de Pointes); - Diagnosed or suspected congenital or acquired prolonged QT syndrome; - Need for medications known to prolong the QT interval; - Uncorrected hypomagnesemia or hypokalemia because of potential effects on the QT interval; - Left ventricular ejection fraction <50% or shortening fraction <28%.

14. Recent or ongoing clinically significant gastrointestinal disorder that may interfere with absorption of orally administered drugs (eg, gastrectomy). 15. Evidence of serious active or uncontrolled bacterial, fungal or viral infection or known history of hepatitis B virus, hepatitis C virus, or human immunodeficiency virus infection or acquired immunodeficiency syndrome-related illness. Screening for viral hepatitis and HIV is under discretion of investigator unless required by local regulation. 16. Severe acute or chronic medical or laboratory test abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results, and in the judgment of the Investigator, would make the patient inappropriate for entry into this study. 17. Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or patients who are Pfizer employees, including their family members, directly involved in the conduct of the study. 18. Fertile male patients or female patients of childbearing potential who are unwilling or unable to follow contraceptive requirements. 19. Pregnant or breastfeeding women.

Trial Details

Trial ID: This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.	NCT03709680
Phase Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.	Phase 2
Lead Sponsor The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.	Pfizer
Principal Investigator The person who is responsible for the scientific and technical direction of the entire clinical study.	Pfizer CT.gov Call Center
Principal Investigator Affiliation	Pfizer
Agency Class Category of organization(s) involved as sponsor (and collaborator) supporting the trial.	Industry, Other
Overall Status	Active, not recruiting
Countries	Brazil, Canada, Czechia, France, Germany, India, Poland, Slovakia, South Korea, Spain, Sweden, Turkey (Türkiye), United Kingdom, United States
Conditions The disease, disorder, syndrome, illness, or injury that is being studied.	Ewing Sarcoma, Solid Tumors, Rhabdoid Tumor, Rhabdomyosarcoma, Neuroblastoma, Medulloblastoma, Diffuse Intrinsic Pontine Glioma
Study Website:	View Trial Website

Arms & Interventions

Arms

Experimental: Phase 2 Arm A

Palbociclib in combination with irinotecan and temozolomide.

Experimental: Phase 1

Palbociclib in combination with temozolomide and irinotecan and/or with topotecan and cyclophosphamide.

Active Comparator: Phase 2 Arm B

Irinotecan and temozolomide alone.

Experimental: Phase 1 Tumor specific cohort - Neuroblastoma

Palbociclib in combination with topotecan and cyclophosphamide.

Interventions

Drug: - Palbociclib

Phase 1: Administered (oral) at 55 mg/m2, 75 mg/m2, or 40 mg/m2, or 95 mg/m2 or 115 mg/m2 on days 1-14 of a 21-day cycle Phase 1 Tumor specific cohort-Neuroblastoma and Phase 2 : Administered (oral) at 75 mg/m2 on days 1-14 of a 21-day cycle

Drug: - Temozolomide

Phase 1 and Phase 2: Administered at 100 mg/m2 (oral or intravenous), on days 1-5 of a 21-day cycle

Drug: - Irinotecan

Phase 1 and Phase 2: Administered at 50 mg/m2 (intravenous), on days 1-5 of a 21-day cycle

Drug: - Topotecan

Phase 1 only : Administered at 0.75 mg/m2 (intravenous), on days 1-5 of a 21-day cycle

Drug: - Cyclophosphamide

Phase 1 only: Administered at 250 mg/m2 (intravenous), on days 1-5 of a 21-day cycle

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

Birmingham 4049979, Alabama 4829764

Status

Address

University of Alabama at Birmingham/Children's of Alabama

Birmingham 4049979, Alabama 4829764, 35233

Phoenix Children's Hospital, Phoenix 5308655, Arizona 5551752

Status

Address

Phoenix Children's Hospital

Phoenix 5308655, Arizona 5551752, 85016

Long Beach 5367929, California 5332921

Status

Address

MemorialCare Health System - Long Beach Medical Center

Long Beach 5367929, California 5332921, 90806

Children's Hospital Los Angeles, Los Angeles 5368361, California 5332921

Status

Address

Children's Hospital Los Angeles

Los Angeles 5368361, California 5332921, 90027

Oakland 5378538, California 5332921

Status

Address

Children's Hospital and Research Center at Oakland

Oakland 5378538, California 5332921, 94609

Children's Hospital of Orange County, Orange 5379513, California 5332921

Status

Address

Children's Hospital of Orange County

Orange 5379513, California 5332921, 92868

Lucile Packard Children's Hospital, Palo Alto 5380748, California 5332921

Status

Address

Lucile Packard Children's Hospital

Palo Alto 5380748, California 5332921, 94304

UCSF Medical Center, San Francisco 5391959, California 5332921

Status

Address

UCSF Medical Center

San Francisco 5391959, California 5332921, 94158

University of California San Francisco,, San Francisco 5391959, California 5332921

Status

Address

University of California San Francisco,

San Francisco 5391959, California 5332921, 94158

Children's Hospital Colorado, Aurora 5412347, Colorado 5417618

Status

Address

Children's Hospital Colorado

Aurora 5412347, Colorado 5417618, 80045

Children's National Hospital, Washington D.C. 4140963, District of Columbia 4138106

Status

Address

Children's National Hospital

Washington D.C. 4140963, District of Columbia 4138106, 20010

UF Health Shands Hospital, Gainesville 4156404, Florida 4155751

Status

Address

UF Health Shands Hospital

Gainesville 4156404, Florida 4155751, 32610

Gainesville 4156404, Florida 4155751

Status

Address

University of Florida College of Medicine

Gainesville 4156404, Florida 4155751, 32610

Johns Hopkins All Children's Hospital, St. Petersburg 4171563, Florida 4155751

Status

Address

Johns Hopkins All Children's Hospital

St. Petersburg 4171563, Florida 4155751, 33701

St. Petersburg 4171563, Florida 4155751

Status

Address

Johns Hopkins All Children's Outpatient Care Center

St. Petersburg 4171563, Florida 4155751, 33701

Johns Hopkins All Children's Hospital, Tampa 4174757, Florida 4155751

Status

Address

Johns Hopkins All Children's Hospital

Tampa 4174757, Florida 4155751, 33612

Atlanta 4180439, Georgia 4197000

Status

Address

Children's Healthcare of Atlanta at Egleston

Atlanta 4180439, Georgia 4197000, 30322

Atlanta 4180439, Georgia 4197000

Status

Address

Children's Healthcare of Atlanta at Scottish Rite

Atlanta 4180439, Georgia 4197000, 30342

Atlanta 4180439, Georgia 4197000

Status

Address

Children's Healthcare of Atlanta, Medical Office Building

Atlanta 4180439, Georgia 4197000, 30342

Chicago 4887398, Illinois 4896861

Status

Address

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago 4887398, Illinois 4896861, 60611

Indiana University, Indianapolis 4259418, Indiana 4921868

Status

Address

Indiana University

Indianapolis 4259418, Indiana 4921868, 46202

Norton Children's Hospital, Louisville 4299276, Kentucky 6254925

Status

Address

Norton Children's Hospital

Louisville 4299276, Kentucky 6254925, 40202

Novak Center for Children's Health, Louisville 4299276, Kentucky 6254925

Status

Address

Novak Center for Children's Health

Louisville 4299276, Kentucky 6254925, 40202

Johns Hopkins University, Baltimore 4347778, Maryland 4361885

Status

Address

Johns Hopkins University

Baltimore 4347778, Maryland 4361885, 21287

University of Michigan Health System, Ann Arbor 4984247, Michigan 5001836

Status

Address

University of Michigan Health System

Ann Arbor 4984247, Michigan 5001836, 48109

Minneapolis 5037649, Minnesota 5037779

Status

Address

University of Minnesota Masonic Children's Hospital

Minneapolis 5037649, Minnesota 5037779, 55454

Minneapolis 5037649, Minnesota 5037779

Status

Address

University of Minnesota Medical Center, Fairview

Minneapolis 5037649, Minnesota 5037779, 55455

Minneapolis 5037649, Minnesota 5037779

Status

Address

University of Minnesota/Masonic Cancer Center

Minneapolis 5037649, Minnesota 5037779, 55455

University of Minnesota, Minneapolis 5037649, Minnesota 5037779

Status

Address

University of Minnesota

Minneapolis 5037649, Minnesota 5037779, 55455

University of Mississippi Medical Center, Jackson 4431410, Mississippi 4436296

Status

Address

University of Mississippi Medical Center

Jackson 4431410, Mississippi 4436296, 39216

Children's Mercy Hospital, Kansas City 4393217, Missouri 4398678

Status

Address

Children's Mercy Hospital

Kansas City 4393217, Missouri 4398678, 64108

Washington University School of Medicine, St Louis 4407066, Missouri 4398678

Status

Address

Washington University School of Medicine

St Louis 4407066, Missouri 4398678, 63110

Robert Wood Johnson University Hospital, New Brunswick 5101717, New Jersey 5101760

Status

Address

Robert Wood Johnson University Hospital

New Brunswick 5101717, New Jersey 5101760, 08901

Rutgers Cancer Institute of New Jersey, New Brunswick 5101717, New Jersey 5101760

Status

Address

Rutgers Cancer Institute of New Jersey

New Brunswick 5101717, New Jersey 5101760, 08903

John R. Oishei Childrens Hospital, Buffalo 5110629, New York 5128638

Status

Address

John R. Oishei Childrens Hospital

Buffalo 5110629, New York 5128638, 14203

Roswell Park Cancer Institute, Buffalo 5110629, New York 5128638

Status

Address

Roswell Park Cancer Institute

Buffalo 5110629, New York 5128638, 14263

Cohen Children's Medical Center, New Hyde Park 5128514, New York 5128638

Status

Address

Cohen Children's Medical Center

New Hyde Park 5128514, New York 5128638, 11040

New York 5128581, New York 5128638

Status

Address

Morgan Stanley Children's Hospital of New York-Presbyetrian Hospital

New York 5128581, New York 5128638, 10032

Montefiore Medical Center, The Bronx 5110266, New York 5128638

Status

Address

Montefiore Medical Center

The Bronx 5110266, New York 5128638, 10467

Cincinnati 4508722, Ohio 5165418

Status

Address

Cincinnati Children's Hospital Medical Center

Cincinnati 4508722, Ohio 5165418, 45229

Cleveland 5150529, Ohio 5165418

Status

Address

University Hospitals Cleveland Medical Center

Cleveland 5150529, Ohio 5165418, 44106

Nationwide Children's Hospital, Columbus 4509177, Ohio 5165418

Status

Address

Nationwide Children's Hospital

Columbus 4509177, Ohio 5165418, 43205

Cincinnati Children's Liberty Campus, Liberty Township 7126297, Ohio 5165418

Status

Address

Cincinnati Children's Liberty Campus

Liberty Township 7126297, Ohio 5165418, 45044

Oklahoma City 4544349, Oklahoma 4544379

Status

Address

University of Oklahoma Health Sciences Center

Oklahoma City 4544349, Oklahoma 4544379, 73104

Oregon Health & Science University, Portland 5746545, Oregon 5744337

Status

Address

Oregon Health & Science University

Portland 5746545, Oregon 5744337, 97239

Hershey 5193342, Pennsylvania 6254927

Status

Address

Penn State Children's Hospital and Penn State Health Milton S. Hershey Medical Center

Hershey 5193342, Pennsylvania 6254927, 17033

Philadelphia 4560349, Pennsylvania 6254927

Status

Address

Buerger Center for Advanced Pediatric Care

Philadelphia 4560349, Pennsylvania 6254927, 19104

Children's Hospital of Philadelphia, Philadelphia 4560349, Pennsylvania 6254927

Status

Address

Children's Hospital of Philadelphia

Philadelphia 4560349, Pennsylvania 6254927, 19104

UPMC Children's Hospital of Pittsburgh, Pittsburgh 5206379, Pennsylvania 6254927

Status

Address

UPMC Children's Hospital of Pittsburgh

Pittsburgh 5206379, Pennsylvania 6254927, 15224

Children's Blood and Cancer Center, Austin 4671654, Texas 4736286

Status

Address

Children's Blood and Cancer Center

Austin 4671654, Texas 4736286, 78723

Dell Children's Medical Center, Austin 4671654, Texas 4736286

Status

Address

Dell Children's Medical Center

Austin 4671654, Texas 4736286, 78723

Children's Medical Center Dallas, Dallas 4684888, Texas 4736286

Status

Address

Children's Medical Center Dallas

Dallas 4684888, Texas 4736286, 75235

Cook Children's Medical Center, Fort Worth 4691930, Texas 4736286

Status

Address

Cook Children's Medical Center

Fort Worth 4691930, Texas 4736286, 76104

Cook Children's H/O Infusion Center, Grapevine 4694568, Texas 4736286

Status

Address

Cook Children's H/O Infusion Center

Grapevine 4694568, Texas 4736286, 76051

Texas Children's Hospital, Houston 4699066, Texas 4736286

Status

Address

Texas Children's Hospital

Houston 4699066, Texas 4736286, 77030

Children's Medical Center Plano, Plano 4719457, Texas 4736286

Status

Address

Children's Medical Center Plano

Plano 4719457, Texas 4736286, 75024

Salt Lake City 5780993, Utah 5549030

Status

Address

Intermountain - Primary Children's Hospital

Salt Lake City 5780993, Utah 5549030, 84113

Salt Lake City 5780993, Utah 5549030

Status

Address

Primary Children's Hospital Outpatient Services

Salt Lake City 5780993, Utah 5549030, 84113

Norfolk 4776222, Virginia 6254928

Status

Address

Children's Hospital of The King's Daughters

Norfolk 4776222, Virginia 6254928, 23507

Children's Hospital of Richmond at VCU, Richmond 4781708, Virginia 6254928

Status

Address

Children's Hospital of Richmond at VCU

Richmond 4781708, Virginia 6254928, 23219

Seattle Children's Hospital, Seattle 5809844, Washington 5815135

Status

Address

Seattle Children's Hospital

Seattle 5809844, Washington 5815135, 98105

Children's Wisconsin, Milwaukee 5263045, Wisconsin 5279468

Status

Address

Children's Wisconsin

Milwaukee 5263045, Wisconsin 5279468, 53226

Medical College of Wisconsin, Milwaukee 5263045, Wisconsin 5279468

Status

Address

Medical College of Wisconsin

Milwaukee 5263045, Wisconsin 5279468, 53226

International Sites

Curitiba 3464975, Paraná 3455077, Brazil

Status

Address

Hospital Pequeno Principe / A ssociacao Hospitalar de Protecao a Infancia

Curitiba 3464975, Paraná 3455077, 80250-060

Hospital Pequeno Príncipe, Curitiba 3464975, Paraná 3455077, Brazil

Status

Address

Hospital Pequeno Príncipe

Curitiba 3464975, Paraná 3455077, 80250-060

Hospital de Clinicas de Porto Alegre, Porto Alegre 3452925, Rio Grande do Sul 3451133, Brazil

Status

Address

Hospital de Clinicas de Porto Alegre

Porto Alegre 3452925, Rio Grande do Sul 3451133, 90035-903

Hospital de Clinicas de Porto Alegre, Porto Alegre 3452925, Rio Grande do Sul 3451133, Brazil

Status

Address

Hospital de Clinicas de Porto Alegre

Porto Alegre 3452925, Rio Grande do Sul 3451133, 90410000

Barretos 3470451, São Paulo 3448433, Brazil

Status

Address

Fundação Pio XII - Hospital de Câncer de Barretos

Barretos 3470451, São Paulo 3448433, 14784400

Instituto Nacional de Câncer - INCA, Rio de Janeiro 3451190, Brazil

Status

Address

Instituto Nacional de Câncer - INCA

Rio de Janeiro 3451190, , 20230-130

Hospital Santa Marcelina, São Paulo 3448439, Brazil

Status

Address

Hospital Santa Marcelina

São Paulo 3448439, , 08270-070

Alberta Children's Hospital, Calgary 5913490, Alberta 5883102, Canada

Status

Address

Alberta Children's Hospital

Calgary 5913490, Alberta 5883102, T3B 6A8

Stollery Children's Hospital, Edmonton 5946768, Alberta 5883102, Canada

Status

Address

Stollery Children's Hospital

Edmonton 5946768, Alberta 5883102, T6G 2B7

The Hospital for Sick Children, Toronto 6167865, Ontario 6093943, Canada

Status

Address

The Hospital for Sick Children

Toronto 6167865, Ontario 6093943, M5G 1X8

CHU Sainte-Justine, Montreal 6077243, Quebec 6115047, Canada

Status

Address

CHU Sainte-Justine

Montreal 6077243, Quebec 6115047, H3T 1C5

Detska nemocnice FN Brno, Brno 3078610, Brno-město, Czechia

Status

Address

Detska nemocnice FN Brno

Brno 3078610, Brno-město, 613 00

Fakultni nemocnice v Motole, Prague 3067696, Praha 5, Czechia

Status

Address

Fakultni nemocnice v Motole

Prague 3067696, Praha 5, 150 06

Bordeaux 3031582, Aquitaine, France

Status

Address

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux 3031582, Aquitaine, 33076

Centre Leon Berard, Lyon 2996944, Auvergne-Rhône-Alpes 11071625, France

Status

Address

Centre Leon Berard

Lyon 2996944, Auvergne-Rhône-Alpes 11071625, 69008

Centre Leon Berard, Lyon 2996944, Auvergne-Rhône-Alpes 11071625, France

Status

Address

Centre Leon Berard

Lyon 2996944, Auvergne-Rhône-Alpes 11071625, 69373 CEDEX 08

Gustave Roussy, Villejuif 2968705, Val-de-marne, France

Status

Address

Gustave Roussy

Villejuif 2968705, Val-de-marne, 94800

Marseille 2995469, France

Status

Address

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Marseille 2995469, , 13385

Universitätsklinikum Essen, Essen 2928810, North Rhine-Westphalia 2861876, Germany

Status

Address

Universitätsklinikum Essen

Essen 2928810, North Rhine-Westphalia 2861876, 45122

Artemis hospital, Gurugram 1270642, Haryana 1270260, India

Status

Address

Artemis hospital

Gurugram 1270642, Haryana 1270260, 122001

All India Institute of Medical Sciences, New Delhi 1261481, National Capital Territory of Delhi 1273293, India

Status

Address

All India Institute of Medical Sciences

New Delhi 1261481, National Capital Territory of Delhi 1273293, 110029

New Delhi 1261481, National Capital Territory of Delhi 1273293, India

Status

Address

Rajiv Gandhi Cancer Institute And Research Centre

New Delhi 1261481, National Capital Territory of Delhi 1273293, 110085

Instytut Matki i Dziecka, Warsaw 756135, Masovian Voivodeship 858787, Poland

Status

Address

Instytut Matki i Dziecka

Warsaw 756135, Masovian Voivodeship 858787, 01-211

Banská Bystrica 3061186, Slovakia

Status

Address

Detska fakultna nemocnica s poliklinikou Banska Bystrica

Banská Bystrica 3061186, , 974 09

Narodny ustav detskych chorob, Bratislava 3060972, Slovakia

Status

Address

Narodny ustav detskych chorob

Bratislava 3060972, , 83340

National Cancer Center, Goyang-si 1842485, Kyǒnggi-do, South Korea

Status

Address

National Cancer Center

Goyang-si 1842485, Kyǒnggi-do, 10408

Seoul National University Hospital, Seoul 1835848, Seoul-teukbyeolsi [seoul], South Korea

Status

Address

Seoul National University Hospital

Seoul 1835848, Seoul-teukbyeolsi [seoul], 03080

Asan Medical Center, Seoul 1835848, Seoul-teukbyeolsi [seoul], South Korea

Status

Address

Asan Medical Center

Seoul 1835848, Seoul-teukbyeolsi [seoul], 05505

Samsung Medical Center, Seoul 1835848, Seoul-teukbyeolsi [seoul], South Korea

Status

Address

Samsung Medical Center

Seoul 1835848, Seoul-teukbyeolsi [seoul], 06351

Hospital Universitari Vall d'Hebron, Barcelona 3128760, Barcelona [barcelona], Spain

Status

Address

Hospital Universitari Vall d'Hebron

Barcelona 3128760, Barcelona [barcelona], 08035

Madrid 3117735, Madrid, Comunidad de, Spain

Status

Address

Hospital Infantil Universitario Niño Jesús

Madrid 3117735, Madrid, Comunidad de, 28009

Sahlgrenska Universitetssjukhuset Östra, Gothenburg 2711537, Västra Götalands LÄN [se-14], Sweden

Status

Address

Sahlgrenska Universitetssjukhuset Östra

Gothenburg 2711537, Västra Götalands LÄN [se-14], 416 50

Ege Universitesi Hastanesi, Izmir 311046, İ̇zmir, Turkey (Türkiye)

Status

Address

Ege Universitesi Hastanesi

Izmir 311046, İ̇zmir, 35100

Hacettepe Universite Hastaneleri, Ankara 323786, Turkey (Türkiye)

Status

Address

Hacettepe Universite Hastaneleri

Ankara 323786, , 06100

Royal Victoria Infirmary, Newcastle upon Tyne 2641673, England 6269131, United Kingdom

Status

Address

Royal Victoria Infirmary

Newcastle upon Tyne 2641673, England 6269131, NE1 4LP

Royal Hospital for Children, Glasgow 2648579, Scotland 2638360, United Kingdom

Status

Address

Royal Hospital for Children

Glasgow 2648579, Scotland 2638360, G51 4TF

Leeds General Infirmary, Leeds 2644688, United Kingdom

Status

Address

Leeds General Infirmary

Leeds 2644688, , LS1 3EX

London 2643743, United Kingdom

Status

Address

University College London Hospital, NHS Foundation Trust

London 2643743, , NW1 2PG

Clinical Trial Finder