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Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial
Study Purpose
This phase II pediatric MATCH treatment trial studies how well selpercatinib works in treating patients with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes in an important signaling pathway (called the RET pathway) and may reduce tumor size.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
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Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 12 Months - 21 Years |
| Gender | All |
Inclusion Criteria:
- - Patient must have enrolled onto APEC1621SC and must have been given a treatment assignment to MATCH to APEC1621N based on the presence of an actionable mutation.
- - Patients must be >= 12 months and =< 21 years of age at the time of study enrollment.
- - Patients must have radiographically measurable disease at the time of study enrollment.
- - Note: The following do not qualify as measurable disease: - Malignant fluid collections (e.g., ascites, pleural effusions) - Bone marrow infiltration except that detected by MIBG scan for neuroblastoma.
- - Lesions only detected by nuclear medicine studies (e.g., bone, gallium or positron emission tomography [PET] scans) except as noted for neuroblastoma.
- - Elevated tumor markers in plasma or cerebral spinal fluid (CSF) - Previously radiated lesions that have not demonstrated clear progression post radiation.
- - Leptomeningeal lesions that do not meet the measurement requirements for Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.
- - Karnofsky >= 50% for patients > 16 years of age and Lansky >= 50 for patients =< 16 years of age.
- - Patients must have fully recovered from the acute toxic effects of all prior anti-cancer therapy and must meet the following minimum duration from prior anti-cancer directed therapy prior to enrollment.
- - Cytotoxic chemotherapy or other anti-cancer agents known to be myelosuppressive.
- - >= 21 days after the last dose of cytotoxic or myelosuppressive chemotherapy (42 days if prior nitrosourea) - Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced platelet or absolute neutrophil [ANC] counts): >= 7 days after the last dose of agent.
- - Antibodies: >= 21 days must have elapsed from infusion of last dose of antibody, and toxicity related to prior antibody therapy must be recovered to grade =< 1.
- - Corticosteroids: If used to modify immune adverse events related to prior therapy, >= 14 days must have elapsed since last dose of corticosteroid.
- - Hematopoietic growth factors: >= 14 days after the last dose of a long-acting growth factor (e.g. pegfilgrastim) or 7 days for short-acting growth factor.
- - Interleukins, interferons and cytokines (other than hematopoietic growth factors): >= 21 days after the completion of interleukins, interferon or cytokines (other than hematopoietic growth factors) - Stem cell infusions (with or without total body irradiation [TBI]): - Allogeneic (non-autologous) bone marrow or stem cell transplant, or any stem cell infusion including donor lymphocyte infusion (DLI) or boost infusion: >= 84 days after infusion and no evidence of graft versus host disease (GVHD) - Autologous stem cell infusion including boost infusion: >= 42 days.
- - Cellular therapy: >= 42 days after the completion of any type of cellular therapy (e.g. modified T cells, natural killer [NK] cells, dendritic cells, etc.) - Radiation therapy (XRT)/external beam irradiation including protons: >= 14 days after local XRT; >= 150 days after TBI, craniospinal XRT or if radiation to >= 50% of the pelvis; >= 42 days if other substantial bone marrow (BM) radiation.
- - Note: Radiation may not be delivered to "measurable disease" tumor site(s) being used to follow response to subprotocol treatment.
- - Radiopharmaceutical therapy (e.g., radiolabeled antibody, 131I-MIBG): >= 42 days after systemically administered radiopharmaceutical therapy.
- - Patients must not have received prior exposure to selpercatinib (LOXO-292) or other specific RET inhibitors.
- - For patients with solid tumors without known bone marrow involvement (within 7 days prior to enrollment): - Peripheral absolute neutrophil count (ANC) >= 1000/mm^3.
- - For patients with solid tumors without known bone marrow involvement (within 7 days prior to enrollment): - Platelet count >= 100,000/mm^3 (transfusion independent, defined as not receiving platelet transfusions for at least 7 days prior to enrollment) - Patients with known bone marrow metastatic disease will be eligible for study provided they meet the blood counts (may receive transfusions provided they are not known to be refractory to red cell or platelet transfusions).
- - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2 (within 7 days prior to enrollment) or a serum creatinine based on age/gender as follows (within 7 days prior to enrollment): - Age: Maximum serum creatinine (mg/dL) - 1 to < 2 years: male (0.6), female (0.6) - 2 to < 6 years: male (0.8), female (0.8) - 6 to < 10 years: male (1), female (1) - 10 to < 13 years: male (1.2), female (1.2) - 13 to < 16 years: male (1.5), female (1.4) - >= 16 years: male (1.7), female (1.4) - Bilirubin (sum of conjugated + unconjugated) =< 1.5 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135 U/L.
- - Serum albumin >= 2 g/dL (within 7 days prior to enrollment) - Corrected QT (QTc) interval =< 480 milliseconds (within 7 days prior to enrollment) - All patients and/or their parents or legally authorized representatives must sign a written informed consent.
Exclusion Criteria:
- - Pregnant or breast-feeding women will not be entered on this study due to risks of fetal and teratogenic adverse events as seen in animal/human studies.
- (2) highly effective contraceptive method for the duration of study treatment and for at least 2 weeks after the last dose of selpercatinib (LOXO-292).
- - Patients receiving corticosteroids who have not been on a stable or decreasing dose of corticosteroid for at least 7 days prior to enrollment are not eligible.
- - Patients who are currently receiving another investigational drug are not eligible.
- - Patients who are currently receiving other anti-cancer agents are not eligible.
- - Patients who are receiving cyclosporine, tacrolimus or other agents to prevent graft-versus-host disease post bone marrow transplant are not eligible for this trial.
- - Patients who are currently receiving drugs that are moderate or strong inducers or inhibitors of CYP3A4 are not eligible.
- - Proton pump inhibitors (PPIs), H2 receptor antagonists and antacids: Concomitant use of PPIs during selpercatinib (LOXO-292) therapy should be avoided if feasible.
- - Patients who have major surgery within 14 days prior to cycle 1 day 1 (C1D1) are not eligible.
- - Patients with known clinically significant active malabsorption syndrome or other condition likely to affect gastrointestinal absorption of selpercatinib (LOXO-292) are excluded.
- - Patients with known hypersensitivity to any of the components of the investigational agent, LOXO 292 are excluded.
- - Patients with uncontrolled hypertension are excluded.
- - Patients with uncontrolled symptomatic hyperthyroidism and hypothyroidism (i.e. the patient required a modification to current thyroid medication in 7 days prior to enrollment) are excluded.
- - Patients with uncontrolled symptomatic hypercalcemia and hypocalcemia are excluded.
- - Patients who have an uncontrolled infection are not eligible.
- - Patients who have received a prior solid organ transplantation are not eligible.
Trial Details
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Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04320888 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 2 |
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Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
National Cancer Institute (NCI) |
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Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Andrea T Franson |
| Principal Investigator Affiliation | Children's Oncology Group |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
NIH, Other |
| Overall Status | Active, not recruiting |
| Countries | Australia, Puerto Rico, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Hematopoietic and Lymphatic System Neoplasm, Recurrent Ependymoma, Recurrent Ewing Sarcoma, Recurrent Hepatoblastoma, Recurrent Histiocytic and Dendritic Cell Neoplasm, Recurrent Langerhans Cell Histiocytosis, Recurrent Lymphoma, Recurrent Malignant Germ Cell Tumor, Recurrent Malignant Glioma, Recurrent Malignant Solid Neoplasm, Recurrent Medulloblastoma, Recurrent Neuroblastoma, Recurrent Non-Hodgkin Lymphoma, Recurrent Osteosarcoma, Recurrent Peripheral Primitive Neuroectodermal Tumor, Recurrent Rhabdoid Tumor, Recurrent Rhabdomyosarcoma, Recurrent Soft Tissue Sarcoma, Recurrent WHO Grade 2 Glioma, Refractory Ependymoma, Refractory Ewing Sarcoma, Refractory Hepatoblastoma, Refractory Histiocytic and Dendritic Cell Neoplasm, Refractory Langerhans Cell Histiocytosis, Refractory Lymphoma, Refractory Malignant Germ Cell Tumor, Refractory Malignant Glioma, Refractory Malignant Solid Neoplasm, Refractory Medulloblastoma, Refractory Neuroblastoma, Refractory Non-Hodgkin Lymphoma, Refractory Osteosarcoma, Refractory Peripheral Primitive Neuroectodermal Tumor, Refractory Rhabdoid Tumor, Refractory Rhabdomyosarcoma, Refractory Soft Tissue Sarcoma, Refractory WHO Grade 2 Glioma, Wilms Tumor |
PRIMARY OBJECTIVE:
- I. To determine the objective response rate (ORR; complete response + partial response) in pediatric patients treated with selpercatinib (LOXO-292) with advanced solid tumors (including central nervous system [CNS] tumors), lymphomas or histiocytic disorders that harbor activating genetic alterations in the RET pathway.
- I. To estimate the progression free survival in pediatric patients treated with selpercatinib (LOXO-292) with advanced solid tumors (including CNS tumors), lymphomas or histiocytic disorders that harbor activating genetic alterations in the RET pathway.
- II. To obtain information about the tolerability of selpercatinib (LOXO-292) in children and adolescents with relapsed or refractory cancer.
- I. To explore approaches to profiling changes in tumor genomics over time through evaluation of circulating tumor deoxyribonucleic acid (DNA).
Arms
Experimental: Treatment (selpercatinib)
Patients receive selpercatinib PO BID on days 1-28. Treatment repeats every 28 days for up to 26 cycles (2 years) in the absence of disease progression or unacceptable toxicity. Patients may also undergo PET, CT, MRI, PET/CT, PET/MRI, and/or CT/MRI, scintigraphy, and x-ray imaging throughout the trial.
Interventions
Procedure: - Computed Tomography
Undergo CT, PET/CT, and/or CT/MRI
Procedure: - Magnetic Resonance Imaging
Undergo MRI, PET/MRI, and/or CT/MRI
Procedure: - Positron Emission Tomography
Undergo PET, PET/CT, and/or PET/MRI
Procedure: - Radionuclide Imaging
Undergo scintigraphy
Drug: - Selpercatinib
Given PO
Procedure: - X-Ray Imaging
Undergo x-ray imaging
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Address
Children's Hospital of Alabama
Birmingham, Alabama, 35233
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Providence Alaska Medical Center
Anchorage, Alaska, 99508
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Address
Banner Children's at Desert
Mesa, Arizona, 85202
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Address
Phoenix Childrens Hospital
Phoenix, Arizona, 85016
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Address
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
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Address
Arkansas Children's Hospital
Little Rock, Arkansas, 72202-3591
Status
Address
Kaiser Permanente Downey Medical Center
Downey, California, 90242
Status
Address
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
Status
Address
Loma Linda University Medical Center
Loma Linda, California, 92354
Status
Address
Miller Children's and Women's Hospital Long Beach
Long Beach, California, 90806
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Address
Children's Hospital Los Angeles
Los Angeles, California, 90027
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Address
Cedars Sinai Medical Center
Los Angeles, California, 90048
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Address
Mattel Children's Hospital UCLA
Los Angeles, California, 90095
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Address
Valley Children's Hospital
Madera, California, 93636
Status
Address
UCSF Benioff Children's Hospital Oakland
Oakland, California, 94609
Status
Address
Kaiser Permanente-Oakland
Oakland, California, 94611
Status
Address
Children's Hospital of Orange County
Orange, California, 92868
Status
Address
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, 94304
Status
Address
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
Status
Address
Rady Children's Hospital - San Diego
San Diego, California, 92123
Status
Address
Naval Medical Center -San Diego
San Diego, California, 92134
Status
Address
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
Status
Address
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, California, 90502
Status
Address
Children's Hospital Colorado
Aurora, Colorado, 80045
Status
Address
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver, Colorado, 80218
Status
Address
Connecticut Children's Medical Center
Hartford, Connecticut, 06106
Status
Address
Yale University
New Haven, Connecticut, 06520
Status
Address
Alfred I duPont Hospital for Children
Wilmington, Delaware, 19803
Status
Address
MedStar Georgetown University Hospital
Washington, District of Columbia, 20007
Status
Address
Children's National Medical Center
Washington, District of Columbia, 20010
Status
Address
Broward Health Medical Center
Fort Lauderdale, Florida, 33316
Status
Address
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908
Status
Address
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
Status
Address
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, 33021
Status
Address
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, 32207
Status
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
Status
Address
Nicklaus Children's Hospital
Miami, Florida, 33155
Status
Address
Miami Cancer Institute
Miami, Florida, 33176
Status
Address
AdventHealth Orlando
Orlando, Florida, 32803
Status
Address
Arnold Palmer Hospital for Children
Orlando, Florida, 32806
Status
Address
Nemours Children's Hospital
Orlando, Florida, 32827
Status
Address
Sacred Heart Hospital
Pensacola, Florida, 32504
Status
Address
Johns Hopkins All Children's Hospital
Saint Petersburg, Florida, 33701
Status
Address
Tampa General Hospital
Tampa, Florida, 33606
Status
Address
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, 33607
Status
Address
Saint Mary's Medical Center
West Palm Beach, Florida, 33407
Status
Address
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, 30329
Status
Address
Memorial Health University Medical Center
Savannah, Georgia, 31404
Status
Address
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
Status
Address
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
Status
Address
Lurie Children's Hospital-Chicago
Chicago, Illinois, 60611
Status
Address
University of Illinois
Chicago, Illinois, 60612
Status
Address
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Status
Address
Loyola University Medical Center
Maywood, Illinois, 60153
Status
Address
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637
Status
Address
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
Status
Address
Riley Hospital for Children
Indianapolis, Indiana, 46202
Status
Address
Ascension Saint Vincent Indianapolis Hospital
Indianapolis, Indiana, 46260
Status
Address
Blank Children's Hospital
Des Moines, Iowa, 50309
Status
Address
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
Status
Address
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536
Status
Address
Norton Children's Hospital
Louisville, Kentucky, 40202
Status
Address
Children's Hospital New Orleans
New Orleans, Louisiana, 70118
Status
Address
Ochsner Medical Center Jefferson
New Orleans, Louisiana, 70121
Status
Address
Eastern Maine Medical Center
Bangor, Maine, 04401
Status
Address
Maine Children's Cancer Program
Scarborough, Maine, 04074
Status
Address
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
Status
Address
Sinai Hospital of Baltimore
Baltimore, Maryland, 21215
Status
Address
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
Status
Address
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
Status
Address
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114
Status
Address
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Status
Address
UMass Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655
Status
Address
C S Mott Children's Hospital
Ann Arbor, Michigan, 48109
Status
Address
Children's Hospital of Michigan
Detroit, Michigan, 48201
Status
Address
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
Status
Address
Michigan State University Clinical Center
East Lansing, Michigan, 48824
Status
Address
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
Status
Address
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
Status
Address
Corewell Health Children's
Royal Oak, Michigan, 48073
Status
Address
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, 55404
Status
Address
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455
Status
Address
University of Mississippi Medical Center
Jackson, Mississippi, 39216
Status
Address
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, 64108
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Address
Cardinal Glennon Children's Medical Center
Saint Louis, Missouri, 63104
Status
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
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Address
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
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Address
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, 68114
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Address
University of Nebraska Medical Center
Omaha, Nebraska, 68198
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Address
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102
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Address
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109
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Address
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135
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Address
Summerlin Hospital Medical Center
Las Vegas, Nevada, 89144
Status
Address
Renown Regional Medical Center
Reno, Nevada, 89502
Status
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
Status
Address
Hackensack University Medical Center
Hackensack, New Jersey, 07601
Status
Address
Morristown Medical Center
Morristown, New Jersey, 07960
Status
Address
Saint Peter's University Hospital
New Brunswick, New Jersey, 08901
Status
Address
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903
Status
Address
Albany Medical Center
Albany, New York, 12208
Status
Address
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
Status
Address
Roswell Park Cancer Institute
Buffalo, New York, 14263
Status
Address
NYU Langone Hospital - Long Island
Mineola, New York, 11501
Status
Address
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, 11040
Status
Address
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
Status
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
Status
Address
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
Status
Address
NYP/Weill Cornell Medical Center
New York, New York, 10065
Status
Address
University of Rochester
Rochester, New York, 14642
Status
Address
Stony Brook University Medical Center
Stony Brook, New York, 11794
Status
Address
State University of New York Upstate Medical University
Syracuse, New York, 13210
Status
Address
New York Medical College
Valhalla, New York, 10595
Status
Address
Mission Hospital
Asheville, North Carolina, 28801
Status
Address
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599
Status
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203
Status
Address
Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204
Status
Address
Duke University Medical Center
Durham, North Carolina, 27710
Status
Address
East Carolina University
Greenville, North Carolina, 27834
Status
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Address
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308
Status
Address
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Status
Address
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, 44106
Status
Address
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
Status
Address
Nationwide Children's Hospital
Columbus, Ohio, 43205
Status
Address
Dayton Children's Hospital
Dayton, Ohio, 45404
Status
Address
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
Status
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Address
Legacy Emanuel Children's Hospital
Portland, Oregon, 97227
Status
Address
Oregon Health and Science University
Portland, Oregon, 97239
Status
Address
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103
Status
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Address
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Status
Address
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134
Status
Address
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224
Status
Address
Rhode Island Hospital
Providence, Rhode Island, 02903
Status
Address
Prisma Health Richland Hospital
Columbia, South Carolina, 29203
Status
Address
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, 29605
Status
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Address
T C Thompson Children's Hospital
Chattanooga, Tennessee, 37403
Status
Address
East Tennessee Childrens Hospital
Knoxville, Tennessee, 37916
Status
Address
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105
Status
Address
The Children's Hospital at TriStar Centennial
Nashville, Tennessee, 37203
Status
Address
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
Status
Address
Dell Children's Medical Center of Central Texas
Austin, Texas, 78723
Status
Address
Driscoll Children's Hospital
Corpus Christi, Texas, 78411
Status
Address
Medical City Dallas Hospital
Dallas, Texas, 75230
Status
Address
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
Status
Address
El Paso Children's Hospital
El Paso, Texas, 79905
Status
Address
Cook Children's Medical Center
Fort Worth, Texas, 76104
Status
Address
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
Status
Address
M D Anderson Cancer Center
Houston, Texas, 77030
Status
Address
Covenant Children's Hospital
Lubbock, Texas, 79410
Status
Address
UMC Cancer Center / UMC Health System
Lubbock, Texas, 79415
Status
Address
Children's Hospital of San Antonio
San Antonio, Texas, 78207
Status
Address
Methodist Children's Hospital of South Texas
San Antonio, Texas, 78229
Status
Address
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
Status
Address
Scott and White Memorial Hospital
Temple, Texas, 76508
Status
Address
Primary Children's Hospital
Salt Lake City, Utah, 84113
Status
Address
University of Vermont and State Agricultural College
Burlington, Vermont, 05405
Status
Address
Inova Fairfax Hospital
Falls Church, Virginia, 22042
Status
Address
Children's Hospital of The King's Daughters
Norfolk, Virginia, 23507
Status
Address
Naval Medical Center - Portsmouth
Portsmouth, Virginia, 23708-2197
Status
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
Status
Address
Seattle Children's Hospital
Seattle, Washington, 98105
Status
Address
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, 99204
Status
Address
Mary Bridge Children's Hospital and Health Center
Tacoma, Washington, 98405
Status
Address
Madigan Army Medical Center
Tacoma, Washington, 98431
Status
Address
West Virginia University Healthcare
Morgantown, West Virginia, 26506
Status
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
Status
Address
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
Status
Address
Children's Hospital of Wisconsin
Milwaukee, Wisconsin, 53226
International Sites
Status
Address
Perth Children's Hospital
Perth, Western Australia, 6009
Status
Address
University Pediatric Hospital
San Juan, , 00926
