Get Involved
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
Study Purpose
This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Pathologically (histologically or cytologically) proven diagnosis of small cell lung cancer within 5 years of registration.
- - Patients with de novo or recurrent small cell lung cancer are permitted.
- - Ten or fewer brain metastases ≤ 3 cm in largest diameter and outside a 5-mm margin around either hippocampus must be visible on contrast-enhanced magnetic resonance imaging (MRI) performed ≤ 21 days prior to study entry.
- - Brain metastases can be diagnosed synchronous to the initial diagnosis of small cell lung cancer or metachronous to the initial diagnosis and management of small cell lung cancer.
- - The total tumor volume must be 30 cm^3 or less.
- - Brain metastases must be diagnosed on MRI, which will include the following elements: - REQUIRED MRI ELEMENTS.
- - Post gadolinium contrast-enhanced T1-weighted three-dimensional (3D) spoiled gradient (SPGR).
- - Pre-contrast T1 weighted imaging (3D imaging sequence strongly encouraged).
- - A minimum of one axial T2 FLAIR (preferred) or T2 sequence is required.
- - ADDITIONAL RECOMMENDATIONS.
- - Recommendation is that an axial T2 FLAIR (preferred) sequence be performed instead of a T2 sequence.
- - Recommendation is that that pre-contrast 3D T1 be performed with the same parameters as the post-contrast 3D T1.
- - Recommendation is that imaging be performed on a 3 Tesla (3T) MRI.
- - Recommendation is that the study participants be scanned on the same MRI instrument at each time point.
- - Recommendation is that if additional sequences are obtained, these should meet the criteria outlined in Kaufmann et al.
- - If additional sequences are obtained, total imaging time should not exceed 60 minutes.
- - History/physical examination.
- - Age ≥ 18.
- - Karnofsky performance status of ≥ 70.
- - Creatinine clearance ≥ 30 ml/min.
- - Following the diagnosis of brain metastases, patients can initiate and treat with systemic (chemotherapy and/or immunotherapy) before enrollment only if their brain metastases are asymptomatic and not located in eloquent locations (e.g., brainstem, pre-/post-central gyrus, visual cortex).
- - Patients with symptomatic brain metastases and/or brain metastases in eloquent locations (e.g., brainstem, pre-/post central gyrus, visual cortex) are eligible for enrollment on the trial; however, the specific treatment approach of starting with systemic therapy alone and delaying brain radiation is not recommended for these patients.
- - Concurrent immunotherapy with brain radiation (SRS or HA-WBRT) is permitted.
- - Negative urine or serum pregnancy test (in women of childbearing potential) within 14 days prior to registration.
- - Patients may have had prior intracranial surgical resection.
- - Because neurocognitive testing is the primary goal of this study, patients must be proficient in English or French Canadian.
- - The patient must provide study-specific informed consent prior to study entry.
- - Patients with impaired decision-making capacity are not permitted on study.
- - ELIGIBILITY CRITERIA PRIOR TO STEP 2 REGISTRATION.
- - The following baseline neurocognitive tests must be completed within 21 days prior to Step 2 registration: HVLT-R, TMT, and COWA.
- - NOTE: Completed baseline neurocognitive tests can be uploaded at the time of Step 1 registration.
Exclusion Criteria:
- - Planned infusion of cytotoxic chemotherapy on the same day as SRS or HA-WBRT treatment.
- - Prior allergic reaction to memantine.
- - Intractable seizures while on adequate anticonvulsant therapy; more than 1 seizure per month for the past 2 months.
- - Patients with definitive leptomeningeal metastases.
- - Known history of demyelinating disease such as multiple sclerosis.
- - Contraindication to MR imaging such as implanted metal devices that are MRI-incompatible, allergy to MRI contrast that cannot be adequately addressed with pre-contrast medications, or foreign bodies that preclude MRI imaging.
- - Current use of (other N-methyl-D-aspartate [NMDA] antagonists) amantadine, ketamine, or dextromethorphan.
- - Radiographic evidence of hydrocephalus or other architectural change of the ventricular system resulting in significant anatomic distortion of the hippocampus, including placement of external ventricular drain or ventriculoperitoneal shunt.
- - Mild cases of hydrocephalus not resulting in significant anatomic distortion of the hippocampus are permitted.
- - Prior radiotherapy to the brain, including SRS, WBRT, or prophylactic cranial irradiation (PCI).
- - Severe, active co-morbidity defined as follows: - Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months.
- - Transmural myocardial infarction within the last 6 months.
- - Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration.
- - Chronic obstructive pulmonary disease exacerbation or other acute respiratory illness precluding study therapy at the time of registration.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04804644 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
NRG Oncology |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Vinai Gondi |
| Principal Investigator Affiliation | NRG Oncology |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Recruiting |
| Countries | Canada, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain, Recurrent Lung Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8 |
PRIMARY OBJECTIVE:
- I. Determine whether stereotactic radiosurgery (SRS) relative to whole brain radiotherapy with hippocampal avoidance (HA-WBRT) plus memantine hydrochloride (memantine) for brain metastases from small cell lung cancer (SCLC) prevents cognitive function failure as measured by cognitive decline on a battery of tests: the Hopkins Verbal Learning Test - Revised (HVLT-R), Controlled Oral Word Association (COWA) test, and the Trail Making Test (TMT).
- I. Determine whether SRS relative to HA-WBRT plus memantine for brain metastases from SCLC preserves cognitive function as separately measured by the HVLT-R, COWA, TMT Parts A and B, and Clinical Trial Battery Composite (CTB COMP).
- II. Assess perceived difficulties in cognitive abilities using Patient Reported Outcomes Measurement Information System (PROMIS) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- III. Assess symptom burden using the MD Anderson Symptom Inventory for brain tumor (MDASI-BT) after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- IV. Compare cumulative incidence of intracranial disease progression after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- V. Compare overall survival after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- VI. Compare cumulative incidence of neurologic death after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- VII. Compare the number of salvage procedures used to manage recurrent intracranial disease following SRS relative to HA-WBRT plus memantine for SCLC brain metastases.
- VIII. Compare adverse events between the treatment arms according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 criteria.
- IX. Compare the risk of developing cerebral necrosis between SRS and HA-WBRT plus memantine in patients receiving concurrent immunotherapy.
- I. Compare cumulative incidence of local brain recurrence, distant brain relapse, and leptomeningeal dissemination after SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- II. Compare the cost of brain-related therapies and quality-adjusted life years in patients who receive SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- III. Evaluate the time delay to salvage WBRT or HA-WBRT in patients enrolled on the SRS arm.
- IV. Evaluate whether a time delay for chemotherapy in patients receiving HA-WBRT plus memantine relative to SRS for brain metastases from SCLC has an effect on overall survival.
- V. Evaluate baseline magnetic resonance (MR) imaging biomarkers of white matter injury and hippocampal volumetry as potential predictors of cognitive decline and differential benefit from SRS relative to HA-WBRT plus memantine for brain metastases from SCLC.
- VI. Evaluate the correlation between neurocognitive functioning and patient-reported outcomes.
- VII. Collect serum, plasma and imaging studies for future translational research analyses.
Arms
Experimental: Arm I (SRS)
Patients undergo SRS over 1 day (in some cases several days).
Active Comparator: Arm II (HA-WBRT, memantine)
Patients also undergo HA-WBRT QD for 2 weeks in the absence of disease progression or unacceptable toxicity. Patients will also receive memantine PO QD or BID for up to 24 weeks in the absence of disease progression or unacceptable toxicity.
Interventions
Drug: - Memantine Hydrochloride
Given PO
Other: - Neurocognitive Assessment
Ancillary studies
Radiation: - Stereotactic Radiosurgery
Undergo SRS
Radiation: - Whole-Brain Radiotherapy
Undergo HA-WBRT
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, 85054
Status
Recruiting
Address
Los Angeles General Medical Center
Los Angeles, California, 90033
Status
Recruiting
Address
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
Status
Recruiting
Address
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
Status
Recruiting
Address
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
Status
Recruiting
Address
Memorial Hospital North
Colorado Springs, Colorado, 80920
Status
Recruiting
Address
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
Status
Recruiting
Address
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, 06437
Status
Recruiting
Address
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510
Status
Recruiting
Address
Yale University
New Haven, Connecticut, 06520
Status
Recruiting
Address
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611
Status
Recruiting
Address
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
Status
Recruiting
Address
Beebe Medical Center
Lewes, Delaware, 19958
Status
Suspended
Address
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
Status
Recruiting
Address
Helen F Graham Cancer Center
Newark, Delaware, 19713
Status
Recruiting
Address
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
Status
Recruiting
Address
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
Status
Recruiting
Address
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, 33442
Status
Active, not recruiting
Address
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
Status
Recruiting
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
Status
Recruiting
Address
Emory University Hospital Midtown
Atlanta, Georgia, 30308
Status
Recruiting
Address
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
Status
Recruiting
Address
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
Status
Recruiting
Address
Northside Hospital
Atlanta, Georgia, 30342
Status
Recruiting
Address
Northside Hospital-Cherokee
Canton, Georgia, 30115
Status
Recruiting
Address
Northside Hospital-Forsyth
Cumming, Georgia, 30041
Status
Recruiting
Address
Rush - Copley Medical Center
Aurora, Illinois, 60504
Status
Recruiting
Address
Centralia Oncology Clinic
Centralia, Illinois, 62801
Status
Recruiting
Address
Rush University Medical Center
Chicago, Illinois, 60612
Status
Recruiting
Address
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
Status
Recruiting
Address
Carle at The Riverfront
Danville, Illinois, 61832
Status
Recruiting
Address
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
Status
Recruiting
Address
Decatur Memorial Hospital
Decatur, Illinois, 62526
Status
Recruiting
Address
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
Status
Recruiting
Address
Carle Physician Group-Effingham
Effingham, Illinois, 62401
Status
Recruiting
Address
Crossroads Cancer Center
Effingham, Illinois, 62401
Status
Recruiting
Address
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
Status
Recruiting
Address
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
Status
Recruiting
Address
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
Status
Recruiting
Address
OSF Saint Francis Medical Center
Peoria, Illinois, 61637
Status
Recruiting
Address
Carle Cancer Center
Urbana, Illinois, 61801
Status
Recruiting
Address
The Carle Foundation Hospital
Urbana, Illinois, 61801
Status
Recruiting
Address
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
Status
Recruiting
Address
Goshen Center for Cancer Care
Goshen, Indiana, 46526
Status
Recruiting
Address
Mary Greeley Medical Center
Ames, Iowa, 50010
Status
Recruiting
Address
McFarland Clinic - Ames
Ames, Iowa, 50010
Status
Suspended
Address
Baptist Health Lexington
Lexington, Kentucky, 40503
Status
Recruiting
Address
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana, 70809
Status
Active, not recruiting
Address
Anne Arundel Medical Center
Annapolis, Maryland, 21401
Status
Recruiting
Address
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
Status
Recruiting
Address
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, 21237
Status
Recruiting
Address
UM Upper Chesapeake Medical Center
Bel Air, Maryland, 21014
Status
Recruiting
Address
Central Maryland Radiation Oncology in Howard County
Columbia, Maryland, 21044
Status
Recruiting
Address
University of Maryland Shore Medical Center at Easton
Easton, Maryland, 21601
Status
Recruiting
Address
TidalHealth Richard A Henson Cancer Institute
Ocean Pines, Maryland, 21811
Status
Recruiting
Address
TidalHealth Peninsula Regional
Salisbury, Maryland, 21801
Status
Recruiting
Address
Boston Medical Center
Boston, Massachusetts, 02118
Status
Recruiting
Address
Saint Joseph Mercy Hospital
Ann Arbor, Michigan, 48106
Status
Recruiting
Address
Saint Joseph Mercy Brighton
Brighton, Michigan, 48114
Status
Recruiting
Address
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, 48114
Status
Recruiting
Address
Saint Joseph Mercy Canton
Canton, Michigan, 48188
Status
Recruiting
Address
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, 48188
Status
Suspended
Address
Caro Cancer Center
Caro, Michigan, 48723
Status
Recruiting
Address
Saint Joseph Mercy Chelsea
Chelsea, Michigan, 48118
Status
Recruiting
Address
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, 48118
Status
Recruiting
Address
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, 48154
Status
Suspended
Address
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan, 48453
Status
Suspended
Address
Ascension Saint Mary's Hospital
Saginaw, Michigan, 48601
Status
Suspended
Address
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan, 48604
Status
Suspended
Address
Ascension Saint Joseph Hospital
Tawas City, Michigan, 48764
Status
Suspended
Address
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan, 48661
Status
Recruiting
Address
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, 48197
Status
Recruiting
Address
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, 56601
Status
Recruiting
Address
Mercy Hospital
Coon Rapids, Minnesota, 55433
Status
Recruiting
Address
Fairview Southdale Hospital
Edina, Minnesota, 55435
Status
Active, not recruiting
Address
Unity Hospital
Fridley, Minnesota, 55432
Status
Recruiting
Address
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
Status
Recruiting
Address
Regions Hospital
Saint Paul, Minnesota, 55101
Status
Recruiting
Address
Lakeview Hospital
Stillwater, Minnesota, 55082
Status
Recruiting
Address
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
Status
Recruiting
Address
Parkland Health Center - Farmington
Farmington, Missouri, 63640
Status
Recruiting
Address
Freeman Health System
Joplin, Missouri, 64804
Status
Recruiting
Address
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
Status
Recruiting
Address
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
Status
Recruiting
Address
Mercy Hospital Springfield
Springfield, Missouri, 65804
Status
Recruiting
Address
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
Status
Recruiting
Address
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
Status
Suspended
Address
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana, 59405
Status
Recruiting
Address
Kalispell Regional Medical Center
Kalispell, Montana, 59901
Status
Active, not recruiting
Address
Montefiore Medical Center-Einstein Campus
Bronx, New York, 10461
Status
Active, not recruiting
Address
Montefiore Medical Center-Weiler Hospital
Bronx, New York, 10461
Status
Active, not recruiting
Address
Montefiore Medical Center - Moses Campus
Bronx, New York, 10467
Status
Recruiting
Address
Sands Cancer Center
Canandaigua, New York, 14424
Status
Recruiting
Address
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
Status
Recruiting
Address
Northern Westchester Hospital
Mount Kisco, New York, 10549
Status
Recruiting
Address
Wilmot Cancer Institute Radiation Oncology at Greece
Rochester, New York, 14606
Status
Recruiting
Address
University of Rochester
Rochester, New York, 14642
Status
Recruiting
Address
State University of New York Upstate Medical University
Syracuse, New York, 13210
Status
Recruiting
Address
Wilmot Cancer Institute at Webster
Webster, New York, 14580
Status
Recruiting
Address
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
Status
Recruiting
Address
Sanford Bismarck Medical Center
Bismarck, North Dakota, 58501
Status
Recruiting
Address
Sanford Broadway Medical Center
Fargo, North Dakota, 58122
Status
Recruiting
Address
Sanford Roger Maris Cancer Center
Fargo, North Dakota, 58122
Status
Recruiting
Address
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
Status
Recruiting
Address
Case Western Reserve University
Cleveland, Ohio, 44106
Status
Recruiting
Address
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Status
Recruiting
Address
Riverside Methodist Hospital
Columbus, Ohio, 43214
Status
Recruiting
Address
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, Ohio, 44060
Status
Recruiting
Address
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio, 43551
Status
Suspended
Address
Mercy Health - Saint Anne Hospital
Toledo, Ohio, 43623
Status
Recruiting
Address
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
Status
Recruiting
Address
Saint Luke's Cancer Center - Allentown
Allentown, Pennsylvania, 18104
Status
Recruiting
Address
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania, 18015
Status
Recruiting
Address
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
Status
Recruiting
Address
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
Status
Recruiting
Address
Geisinger Medical Center
Danville, Pennsylvania, 17822
Status
Recruiting
Address
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania, 18045
Status
Recruiting
Address
Ephrata Cancer Center
Ephrata, Pennsylvania, 17522
Status
Recruiting
Address
Saint Vincent Hospital
Erie, Pennsylvania, 16544
Status
Recruiting
Address
Adams Cancer Center
Gettysburg, Pennsylvania, 17325
Status
Recruiting
Address
Sechler Family Cancer Center
Lebanon, Pennsylvania, 17042
Status
Recruiting
Address
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, 17837
Status
Recruiting
Address
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
Status
Recruiting
Address
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania, 19114
Status
Recruiting
Address
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
Status
Recruiting
Address
Saint Luke's Hospital - Upper Bucks Campus
Quakertown, Pennsylvania, 18951
Status
Recruiting
Address
Saint Luke's Hospital-Quakertown Campus
Quakertown, Pennsylvania, 18951
Status
Recruiting
Address
Saint Luke's Hospital - Monroe Campus
Stroudsburg, Pennsylvania, 18360
Status
Recruiting
Address
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711
Status
Recruiting
Address
WellSpan Health-York Cancer Center
York, Pennsylvania, 17403
Status
Recruiting
Address
WellSpan Health-York Hospital
York, Pennsylvania, 17403
Status
Recruiting
Address
McLeod Regional Medical Center
Florence, South Carolina, 29506
Status
Active, not recruiting
Address
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
Status
Recruiting
Address
Self Regional Healthcare
Greenwood, South Carolina, 29646
Status
Active, not recruiting
Address
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
Status
Active, not recruiting
Address
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
Status
Active, not recruiting
Address
MGC Hematology Oncology-Union
Union, South Carolina, 29379
Status
Recruiting
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
Status
Active, not recruiting
Address
Avera Cancer Institute
Sioux Falls, South Dakota, 57105
Status
Recruiting
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
Status
Active, not recruiting
Address
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
Status
Recruiting
Address
Langlade Hospital and Cancer Center
Antigo, Wisconsin, 54409
Status
Recruiting
Address
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601
Status
Recruiting
Address
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, 53792
Status
Recruiting
Address
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin, 53051
Status
Recruiting
Address
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Status
Recruiting
Address
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
Status
Recruiting
Address
Drexel Town Square Health Center
Oak Creek, Wisconsin, 53154
Status
Recruiting
Address
Ascension Saint Mary's Hospital
Rhinelander, Wisconsin, 54501
Status
Recruiting
Address
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin, 54481
Status
Recruiting
Address
Aspirus Regional Cancer Center
Wausau, Wisconsin, 54401
Status
Recruiting
Address
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin, 53095
International Sites
Status
Recruiting
Address
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1
Status
Recruiting
Address
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4
