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Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
Study Purpose
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases). Stereotactic radiosurgery is a type of radiation therapy that delivers a high dose of radiation to target tumors and minimizes effect on normal surrounding brain tissue. The combination of surgery and radiation may stop the tumor from growing for a few months or longer and may reduce symptoms of brain metastases. This study investigates whether treating with SRS before surgery may be better than SRS after surgery in reducing the possibility of the tumor coming back, reducing or preventing the cancer from spreading to other areas of the brain and reducing the risk of scarring on the brain from radiation.
Recruitment Criteria
|
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
|
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
| Eligible Ages | 18 Years and Over |
| Gender | All |
Inclusion Criteria:
- - Radiographic confirmation of 1-4 brain metastases, one of which requires resection, as defined by magnetic resonance imaging (MRI) with contrast obtained within 14 days prior to registration.
- - The maximum diameter of the lesion to be resected on the post-contrast MRI, as measured on any orthogonal plane (axial, sagittal, coronal), must measure >= 2.0 cm and =< 5.0 cm.
- - The maximum diameter of any lesions which will not be resected must be =< 4.0 cm in maximum diameter.
- - Known active or history of invasive non-central nervous system (CNS) primary cancer based on documented pathologic diagnosis within the past 3 years.
- - All brain metastases must be located >= 5 mm from the optic chiasm and outside the brainstem.
- - Patient is able to medically tolerate surgery and SRS.
- - Lesions chosen for surgical therapy must be deemed appropriate targets for safe, gross total resection by the treating surgeon.
- - History/physical examination within 14 days prior to registration.
- - Age >= 18.
- - Karnofsky performance status (KPS) >= 60 within 14 days prior to registration.
- - A negative urine or serum pregnancy test (in persons of childbearing potential) within =< 14 days prior to registration.
- - Participants who are sexually active must agree to use medically acceptable forms of contraception during treatment on this study to prevent pregnancy.
- - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.
Exclusion Criteria:
- - Prior cranial radiotherapy, including whole brain radiotherapy, or SRS to the resection site.
- - Note: The index lesion to be resected cannot have been previously treated with SRS (i.e. repeat radiosurgery to the same location/lesion is not allowed on this protocol).
- - Evidence of leptomeningeal disease (LMD) - Note: For the purposes of exclusion, LMD is a clinical diagnosis, defined as positive cerebrospinal fluid (CSF) cytology and/or unequivocal radiologic or clinical evidence of leptomeningeal involvement.
- - Any medical conditions which would make this protocol unreasonably hazardous, including, but not limited to: contraindications to general endotracheal anesthesia; intracranial surgery; and stereotactic radiosurgery.
- - Primary histology of germ cell tumor, small cell carcinoma or lymphoma.
- - More than one brain metastasis planned for resection.
- - Inability to undergo MRI with contrast.
- - Planned administration of cytotoxic chemotherapy or tyrosine/multi-kinase inhibitors within the 3 days prior to, the day of, or within 3 days after the completion of SRS.
Trial Details
|
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT05438212 |
|
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
|
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
NRG Oncology |
|
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Stuart H Burri |
| Principal Investigator Affiliation | NRG Oncology |
|
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Other, NIH |
| Overall Status | Recruiting |
| Countries | Canada, Japan, United States |
|
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Metastatic Malignant Neoplasm in the Brain |
PRIMARY OBJECTIVE:
- I. To determine if the time to composite adverse endpoint (CAE) (defined as: 1) local tumor progression within the surgical bed; and/or 2) adverse radiation effect [ARE], the imaging correlate of post-stereotactic radiosurgery [SRS] radiation necrosis; and/or 3) nodular meningeal disease [nMD]) is improved in patients treated with pre-resection SRS to the intact lesion versus those treated with post-resection SRS.
- I. To assess the trajectory of symptom burden in patients treated with pre-resection SRS to the intact lesion versus those treated to the post-resection surgical cavity as measured by MD Anderson Symptom Inventory for brain tumor (MDASI-BT).
- II. To determine whether there is improved overall survival (OS) in patients with resected brain metastases who undergo pre-resection SRS compared to patients who receive post-resection SRS.
- III. To compare rates of ARE, the imaging correlate of radiation necrosis, in patients who receive pre-resection SRS to patients who receive post-resection SRS.
- IV. To determine whether there is increased time to whole brain radiotherapy (WBRT) in patients who receive pre-resection SRS compared to patients who receive post-resection SRS.
- V. To assess the trajectory of neuro-cognitive function in patients treated with pre-resection SRS to the intact lesion versus those treated to the post-resection surgical cavity as measured by the Montreal Cognitive Assessment (MoCA).
- VI. To compare rates of nodular meningeal disease in patients who receive pre-resection SRS to patients who receive post-resection SRS.
- VII. To compare rates of local recurrence in the resection cavity for patients who receive pre-resection SRS to patients who receive post-resection SRS.
- VIII. To compare rates of local recurrence of intact, non-index metastases treated with SRS.
- IX. To compare rates of distant brain failure in patients who receive pre-resection SRS to patients who receive post-resection SRS.
- X. To assess toxicity in the two treatment arms.
- I. To explore if the type of surgical resection (piece-meal versus [vs.
Arms
Active Comparator: Arm I (surgery, stereotactic radiosurgery)
Patients undergo surgery per standard of care. Within 10-30 days after surgery, patients undergo stereotactic radiosurgery for 1 fraction.
Experimental: Arm II (stereotactic radiosurgery, surgery)
Within 7 days before surgery, patients undergo stereotactic radiosurgery for 1 fraction. Patients undergo surgery per standard of care.
Interventions
Procedure: - Brain Surgery
Undergo surgery per standard of care
Other: - Quality-of-Life Assessment
Ancillary studies
Other: - Questionnaire Administration
Ancillary studies
Radiation: - Stereotactic Radiosurgery
Undergo stereotactic radiosurgery
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
Status
Recruiting
Address
Saint Joseph's Hospital and Medical Center
Phoenix 5308655, Arizona 5551752, 85013
Status
Recruiting
Address
Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752, 85719
Status
Recruiting
Address
University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752, 85719
Status
Recruiting
Address
Kaiser Permanente-Anaheim
Anaheim 5323810, California 5332921, 92806
Status
Recruiting
Address
Sutter Auburn Faith Hospital
Auburn 5325223, California 5332921, 95602
Status
Recruiting
Address
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921, 95603
Status
Recruiting
Address
Kaiser Permanente-Bellflower
Bellflower 5327422, California 5332921, 90706
Status
Recruiting
Address
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921, 92612
Status
Recruiting
Address
Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921, 90027
Status
Recruiting
Address
Memorial Medical Center
Modesto 5373900, California 5332921, 95355
Status
Recruiting
Address
Kaiser Permanente-Ontario
Ontario 5379439, California 5332921, 91761
Status
Recruiting
Address
Saint Joseph Hospital - Orange
Orange 5379513, California 5332921, 92868
Status
Recruiting
Address
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921, 92868
Status
Recruiting
Address
Stanford Cancer Institute Palo Alto
Palo Alto 5380748, California 5332921, 94304
Status
Recruiting
Address
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921, 95661
Status
Recruiting
Address
Sutter Roseville Medical Center
Roseville 5388881, California 5332921, 95661
Status
Recruiting
Address
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921, 95816
Status
Recruiting
Address
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921, 95817
Status
Suspended
Address
California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921, 94115
Status
Recruiting
Address
UCSF Medical Center-Parnassus
San Francisco 5391959, California 5332921, 94143
Status
Recruiting
Address
Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921, 95403
Status
Recruiting
Address
Sutter Solano Medical Center/Cancer Center
Vallejo 5405380, California 5332921, 94589
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751, 33146
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751, 33442
Status
Recruiting
Address
Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751, 32224-9980
Status
Recruiting
Address
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751, 33136
Status
Recruiting
Address
Miami Cancer Institute
Miami 4164138, Florida 4155751, 33176
Status
Recruiting
Address
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751, 33324
Status
Recruiting
Address
Moffitt Cancer Center-International Plaza
Tampa 4174757, Florida 4155751, 33607
Status
Recruiting
Address
Moffitt Cancer Center - McKinley Campus
Tampa 4174757, Florida 4155751, 33612
Status
Recruiting
Address
Moffitt Cancer Center
Tampa 4174757, Florida 4155751, 33612
Status
Recruiting
Address
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel 4177727, Florida 4155751, 33544
Status
Recruiting
Address
Grady Health System
Atlanta 4180439, Georgia 4197000, 30303
Status
Recruiting
Address
Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000, 30308
Status
Recruiting
Address
Piedmont Hospital
Atlanta 4180439, Georgia 4197000, 30309
Status
Recruiting
Address
Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000, 30322
Status
Recruiting
Address
Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000, 30342
Status
Recruiting
Address
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797, 96813
Status
Recruiting
Address
Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797, 96813
Status
Recruiting
Address
Queen's Medical Center
Honolulu 5856195, Hawaii 5855797, 96813
Status
Recruiting
Address
Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797, 96813
Status
Recruiting
Address
University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797, 96813
Status
Recruiting
Address
Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797, 96817
Status
Recruiting
Address
The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797, 96817
Status
Recruiting
Address
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797, 96826
Status
Recruiting
Address
Castle Medical Center
Kailua 5847486, Hawaii 5855797, 96734
Status
Recruiting
Address
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue 5850248, Hawaii 5855797, 96766
Status
Recruiting
Address
Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797, 96701
Status
Recruiting
Address
Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797, 96701
Status
Recruiting
Address
The Queen's Medical Center - West Oahu
‘Ewa Beach 5855051, Hawaii 5855797, 96706
Status
Recruiting
Address
Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861, 60506
Status
Recruiting
Address
Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861, 60010
Status
Recruiting
Address
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861, 62801
Status
Recruiting
Address
Northwestern University
Chicago 4887398, Illinois 4896861, 60611
Status
Suspended
Address
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861, 60637
Status
Recruiting
Address
AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861, 60014
Status
Recruiting
Address
Carle at The Riverfront
Danville 4889426, Illinois 4896861, 61832
Status
Recruiting
Address
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861, 62526
Status
Recruiting
Address
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861, 62526
Status
Recruiting
Address
Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861, 60515
Status
Recruiting
Address
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861, 62401
Status
Recruiting
Address
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861, 62401
Status
Suspended
Address
Elmhurst Memorial Hospital
Elmhurst 4891010, Illinois 4896861, 60126
Status
Recruiting
Address
Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861, 60429
Status
Recruiting
Address
AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861, 60048
Status
Recruiting
Address
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861, 61938
Status
Suspended
Address
Edward Hospital/Cancer Center
Naperville 4903279, Illinois 4896861, 60540
Status
Suspended
Address
UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861, 60451
Status
Suspended
Address
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861, 62269
Status
Recruiting
Address
Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861, 60453-2699
Status
Recruiting
Address
Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861, 60068
Status
Recruiting
Address
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861, 62702
Status
Recruiting
Address
Springfield Clinic
Springfield 4250542, Illinois 4896861, 62702
Status
Recruiting
Address
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861, 62781
Status
Recruiting
Address
Carle Cancer Center
Urbana 4914570, Illinois 4896861, 61801
Status
Recruiting
Address
Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861, 60555
Status
Recruiting
Address
Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868, 46260
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182, 50023
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182, 50325
Status
Recruiting
Address
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182, 50309
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182, 50309
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182, 50314
Status
Recruiting
Address
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182, 50263
Status
Recruiting
Address
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885, 21201
Status
Recruiting
Address
UM Upper Chesapeake Medical Center
Bel Air 4348240, Maryland 4361885, 21014
Status
Recruiting
Address
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885, 21061
Status
Recruiting
Address
UM Capital Region Medical Center
Largo 4360345, Maryland 4361885, 20774
Status
Recruiting
Address
University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836, 48109
Status
Not yet recruiting
Address
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836, 48201
Status
Active, not recruiting
Address
Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836, 48334
Status
Recruiting
Address
Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836, 48073
Status
Recruiting
Address
Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836, 48085
Status
Recruiting
Address
Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779, 56401
Status
Recruiting
Address
Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779, 56636
Status
Recruiting
Address
Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779, 55805
Status
Recruiting
Address
Essentia Health Saint Mary's Medical Center
Duluth 5024719, Minnesota 5037779, 55805
Status
Recruiting
Address
Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779, 55805
Status
Recruiting
Address
Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779, 55746
Status
Recruiting
Address
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779, 56303
Status
Recruiting
Address
Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779, 55072
Status
Recruiting
Address
Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779, 55792
Status
Recruiting
Address
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678, 63640
Status
Recruiting
Address
Saint Luke's Hospital of Kansas City
Kansas City 4393217, Missouri 4398678, 64111
Status
Recruiting
Address
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678, 63670
Status
Recruiting
Address
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678, 65804
Status
Recruiting
Address
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678, 63131
Status
Recruiting
Address
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678, 63080
Status
Recruiting
Address
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678, 63127
Status
Recruiting
Address
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009, 59101
Status
Recruiting
Address
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009, 59405
Status
Recruiting
Address
Renown Regional Medical Center
Reno 5511077, Nevada 5509151, 89502
Status
Recruiting
Address
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174, 03756
Status
Recruiting
Address
Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760, 08103
Status
Recruiting
Address
Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760, 07302
Status
Recruiting
Address
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760, 07039
Status
Recruiting
Address
Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760, 08903
Status
Recruiting
Address
Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760, 07112
Status
Recruiting
Address
The Valley Hospital - Luckow Pavilion
Paramus 5102387, New Jersey 5101760, 07652
Status
Recruiting
Address
Capital Health Medical Center-Hopewell
Pennington 5102535, New Jersey 5101760, 08534
Status
Recruiting
Address
Valley Health System Ridgewood Campus
Ridgewood 5103269, New Jersey 5101760, 07450
Status
Recruiting
Address
Community Medical Center
Toms River 4504476, New Jersey 5101760, 08755
Status
Suspended
Address
Valley Health System-Hematology/Oncology
Westwood 5106351, New Jersey 5101760, 07675
Status
Recruiting
Address
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn 5110302, New York 5128638, 11215
Status
Active, not recruiting
Address
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638, 14263
Status
Suspended
Address
The New York Hospital Medical Center of Queens
Flushing 5117472, New York 5128638, 11355
Status
Recruiting
Address
Northern Westchester Hospital
Mount Kisco 5127744, New York 5128638, 10549
Status
Active, not recruiting
Address
Mount Sinai Chelsea
New York 5128581, New York 5128638, 10011
Status
Active, not recruiting
Address
Mount Sinai West
New York 5128581, New York 5128638, 10019
Status
Active, not recruiting
Address
Mount Sinai Hospital
New York 5128581, New York 5128638, 10029
Status
Active, not recruiting
Address
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638, 10032
Status
Recruiting
Address
Manhattan Eye Ear and Throat Hospital
New York 5128581, New York 5128638, 10065
Status
Recruiting
Address
NYP/Weill Cornell Medical Center
New York 5128581, New York 5128638, 10065
Status
Recruiting
Address
Lenox Hill Hospital
New York 5128581, New York 5128638, 10075
Status
Active, not recruiting
Address
University of Rochester
Rochester 5134086, New York 5128638, 14642
Status
Recruiting
Address
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638, 11794
Status
Recruiting
Address
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638, 13210
Status
Recruiting
Address
Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638, 10461
Status
Recruiting
Address
Montefiore Medical Center-Weiler Hospital
The Bronx 5110266, New York 5128638, 10461
Status
Recruiting
Address
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638, 10467
Status
Recruiting
Address
Good Samaritan University Hospital
West Islip 5143866, New York 5128638, 11795
Status
Recruiting
Address
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348, 28203
Status
Recruiting
Address
Atrium Health Cabarrus/LCI-Concord
Concord 4461574, North Carolina 4482348, 28025
Status
Recruiting
Address
CaroMont Regional Medical Center
Gastonia 4467732, North Carolina 4482348, 28054
Status
Recruiting
Address
Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348, 28401
Status
Recruiting
Address
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348, 27157
Status
Recruiting
Address
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Recruiting
Address
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763, 58122
Status
Recruiting
Address
Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418, 45431
Status
Recruiting
Address
Case Western Reserve University
Cleveland 5150529, Ohio 5165418, 44106
Status
Recruiting
Address
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418, 43210
Status
Recruiting
Address
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418, 43214
Status
Recruiting
Address
Grant Medical Center
Columbus 4509177, Ohio 5165418, 43215
Status
Recruiting
Address
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418, 43015
Status
Recruiting
Address
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418, 43015
Status
Recruiting
Address
Kettering Medical Center
Kettering 4515843, Ohio 5165418, 45429
Status
Recruiting
Address
Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418, 43551
Status
Recruiting
Address
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379, 73104
Status
Active, not recruiting
Address
Northeast Radiation Oncology Center
Dunmore 5187542, Pennsylvania 6254927, 18512
Status
Recruiting
Address
Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927, 17033-0850
Status
Active, not recruiting
Address
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927, 19107
Status
Recruiting
Address
UPMC-Presbyterian Hospital
Pittsburgh 5206379, Pennsylvania 6254927, 15213
Status
Recruiting
Address
UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927, 15232
Status
Recruiting
Address
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040, 29425
Status
Recruiting
Address
Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040, 29341
Status
Recruiting
Address
Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040, 29651
Status
Recruiting
Address
Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040, 29303
Status
Recruiting
Address
SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040, 29379
Status
Recruiting
Address
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223, 57104
Status
Recruiting
Address
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223, 57117-5134
Status
Recruiting
Address
The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168, 37203
Status
Suspended
Address
Covenant Medical Center-Lakeside
Lubbock 5525577, Texas 4736286, 79410
Status
Withdrawn
Address
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286, 78229
Status
Active, not recruiting
Address
Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030, 84112
Status
Recruiting
Address
Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928, 22031
Status
Recruiting
Address
Henrico Doctor's Hospital
Richmond 4781708, Virginia 6254928, 23229
Status
Recruiting
Address
CJW Medical Center - Johnston-Willis Campus
Richmond 4781708, Virginia 6254928, 23235
Status
Recruiting
Address
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928, 23298
Status
Recruiting
Address
Carilion Roanoke Memorial Hospital
Roanoke 4782167, Virginia 6254928, 24033
Status
Recruiting
Address
ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468, 54911
Status
Recruiting
Address
Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468, 54806
Status
Recruiting
Address
Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468, 54806
Status
Recruiting
Address
Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468, 53105
Status
Recruiting
Address
Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468, 53022
Status
Recruiting
Address
Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468, 53024
Status
Recruiting
Address
Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468, 54311
Status
Recruiting
Address
Essentia Health-Hayward Clinic
Hayward 5255882, Wisconsin 5279468, 54843
Status
Recruiting
Address
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468, 53038
Status
Recruiting
Address
Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468, 53142
Status
Recruiting
Address
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468, 53718
Status
Recruiting
Address
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468, 53792
Status
Recruiting
Address
Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468, 53209
Status
Recruiting
Address
Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468, 53215
Status
Recruiting
Address
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468, 53226
Status
Recruiting
Address
Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468, 53233
Status
Recruiting
Address
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468, 54904
Status
Recruiting
Address
Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468, 53406
Status
Recruiting
Address
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468, 54501
Status
Recruiting
Address
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468, 53081
Status
Recruiting
Address
Essentia Health-Spooner Clinic
Spooner 5274034, Wisconsin 5279468, 54801
Status
Recruiting
Address
Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468, 54481
Status
Recruiting
Address
Aurora Medical Center in Summit
Summit, Wisconsin 5279468, 53066
Status
Recruiting
Address
Essentia Health Saint Mary's Hospital - Superior
Superior 5275191, Wisconsin 5279468, 54880
Status
Recruiting
Address
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468, 53188
Status
Recruiting
Address
Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468, 54401
Status
Recruiting
Address
Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468, 53226
Status
Recruiting
Address
Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468, 53227
Status
Recruiting
Address
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468, 54494
International Sites
Status
Recruiting
Address
CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal 6077243, Quebec 6115047, H2X 3E4
Status
Recruiting
Address
The Research Institute of the McGill University Health Centre (MUHC)
Montreal 6077243, Quebec 6115047, H3H 2R9
Status
Recruiting
Address
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Québec 6325494, Quebec 6115047, G1R 2J6
Status
Recruiting
Address
Hokkaido University Hospital
Sapporo 2128295, Hokkaido 2130037, 060-8648
Status
Recruiting
Address
Gunma University Hospital
Gunma, Maebashi, 371-8511
Status
Recruiting
Address
Kyoto University Hospital
Kyoto 1857910, , 606-8507
Status
Recruiting
Address
Nagoya University Hospital
Showa-Ku Nagoya, , 466-0065
Status
Recruiting
Address
National Cancer Center Hospital
Tokyo 1850147, , 104 0045
