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Clinical Trial Finder

Search Results

Fluid Responsiveness in Posterior Fossa Tumor Resection: PPV and CVP Guidance

Study Purpose

To answer the question: What are the differences in intraoperative fluid administration volumes between PPV and CVP-guided strategies during posterior fossa tumor resection in the park bench position?

Recruitment Criteria

Accepts Healthy Volunteers

Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms

No
Study Type

An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.


An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.


Searching Both is inclusive of interventional and observational studies.

Interventional
Eligible Ages 18 Years and Over
Gender All
More Inclusion & Exclusion Criteria

Inclusion Criteria:

1. Adult patients aged 18 years and above. 2. American Society of Anesthesiologists (ASA) I and
  • II. 3.
Diagnosis of posterior fossa tumor requiring surgical resection in the park bench position, under general anesthesia at our hospital. 4. Willing to participate in the study.

Exclusion Criteria:

1. Arrhythmia. 2. Significant cardiac diseases. 3. Chronic obstructive airway disease. 4. Elevated intra-abdominal pressure. 5. Tumors prone to precipitate diabetes insipidus. 6. Peripheral vascular disease. 7. Pulmonary hypertension. 8. Patients in sepsis

Trial Details

Trial ID:

This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.

NCT06595667
Phase

Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.

Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.

Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.

Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.

N/A
Lead Sponsor

The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.

Chiang Mai University
Principal Investigator

The person who is responsible for the scientific and technical direction of the entire clinical study.

Pathomporn P Pin on, Associate Professor
Principal Investigator Affiliation Chiang Mai University
Agency Class

Category of organization(s) involved as sponsor (and collaborator) supporting the trial.

Other
Overall Status Active, not recruiting
Countries Thailand
Conditions

The disease, disorder, syndrome, illness, or injury that is being studied.

Posterior Fossa Tumor, Brain Tumor Adult
Additional Details

Prospective RCT is conducted to compared the amount of fluid volume in adult patients undergoing posterior fossa surgery in park bench position.

Arms & Interventions

Arms

Experimental: Pulse pressure variation guidance fluid administration

In the PPV group, fluids will be administered to maintain the PPV below 13%. If hypotension coincided with a PPV exceeding 13%, an initial bolus of 200 ml crystalloid fluid solution will be given in10 minutes. PPV reassessment occurred within the subsequent 10 minutes. Alternatively, if hypotension occurs with a PPV measuring less than 13%, vasopressors such as ephedrine at a dose of 3-6 mg or norepinephrine at a dosage of 5-10 mcg intravenously as a bolus, or norepinephrine infusion at a rate of 0.03-0.3 mcg/kg/min, will be given to sustain mean arterial pressure above 65 mmHg.

Experimental: Central venous pressure guidance fluid administration

In the CVP group, intraoperative fluid administration aimed to maintain CVP between 8-12 cmH2O while on mechanical ventilation, ensuring mean arterial pressure remains above 65 mmHg and heart rate within 20% of baseline.

Interventions

Procedure: - Pulse pressure variation

Fluid administration during posterior fossa surgery in the parkbench position is guided by the PPV value.

Procedure: - Central venous pressure

Fluid administration during posterior fossa surgery in the parkbench position is guided by the CVP value.

Contact a Trial Team

If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.

International Sites

Chiang Mai University, Chiang Mai, Thailand

Status

Address

Chiang Mai University

Chiang Mai, , 50200

Nearest Location


Resources

  • Patient and Caregiver Survey
  • Clinical Trial Endpoints
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The content provided on clinical trials is for informational purposes only and is not a substitute for medical consultation with your healthcare provider. We do not recommend or endorse any specific study and you are advised to discuss the information shown with your healthcare provider. While we believe the information presented on this website to be accurate at the time of writing, we do not guarantee that its contents are correct, complete, or applicable to any particular individual situation. We strongly encourage individuals to seek out appropriate medical advice and treatment from their physicians. We cannot guarantee the availability of any clinical trial listed and will not be responsible if you are considered ineligible to participate in a given clinical trial. We are also not liable for any injury arising as a result of participation.

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